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... by two-way ANOVA, did not reveal a significant main effect of Group (F1,37 = 0.80, P > 0.05) nor Drug (F1,37 = 0.124, P > 0.05). There was, however, a significant Group · Drug interaction (F1,37 = 11.37, P < 0.01). As above, tolerance was demonstrated between EtOH-exposed and control mice given vehi ...
... by two-way ANOVA, did not reveal a significant main effect of Group (F1,37 = 0.80, P > 0.05) nor Drug (F1,37 = 0.124, P > 0.05). There was, however, a significant Group · Drug interaction (F1,37 = 11.37, P < 0.01). As above, tolerance was demonstrated between EtOH-exposed and control mice given vehi ...
pharmacological manipulation of cb1 receptor
... of tolerance to alcohol (EtOH). Methods: An EtOH-inhalation model was used to induce tolerance, as measured by EtOH-induced sedation and hypothermia after a 24 h withdrawal period. Two drug treatment procedures, (i) co-treatment with EtOH and (ii) acute drug administration following chronic EtOH tre ...
... of tolerance to alcohol (EtOH). Methods: An EtOH-inhalation model was used to induce tolerance, as measured by EtOH-induced sedation and hypothermia after a 24 h withdrawal period. Two drug treatment procedures, (i) co-treatment with EtOH and (ii) acute drug administration following chronic EtOH tre ...
Ketamine - thblack.com
... Bell et al. (2006) reviewed 37 RCT (over 2240 participants) use of periop ketamine or placebo. Subanesthetic doses of ketamine (ranging from 10 mg - 270 mg) given at all different time periods (pre-induction, induction, intraop, first ...
... Bell et al. (2006) reviewed 37 RCT (over 2240 participants) use of periop ketamine or placebo. Subanesthetic doses of ketamine (ranging from 10 mg - 270 mg) given at all different time periods (pre-induction, induction, intraop, first ...
Modification of Practice-dependent Plasticity in Human Motor Cortex
... et al., 2005a) while the antiadrenergic a1 receptor antagonist prazosin (Sawaki et al., 2003) and the anticholinergic nonselective muscarinic receptor antagonist scopolamine (Sawaki et al., 2002a) reduced it. These reports suggest that neuromodulating transmitters exert controlling influence on pract ...
... et al., 2005a) while the antiadrenergic a1 receptor antagonist prazosin (Sawaki et al., 2003) and the anticholinergic nonselective muscarinic receptor antagonist scopolamine (Sawaki et al., 2002a) reduced it. These reports suggest that neuromodulating transmitters exert controlling influence on pract ...
Chalcone-based aryloxypropanolamine as a
... Since the discovery of thermogenic properties in 3adrenergic agonists, sincere efforts are being made and analogs of both the arylethanolamine and aryloxypropanolamine classes have been discovered8–10. These agents, however, were unsuccessful in clinical settings because of their unfavourable pharm ...
... Since the discovery of thermogenic properties in 3adrenergic agonists, sincere efforts are being made and analogs of both the arylethanolamine and aryloxypropanolamine classes have been discovered8–10. These agents, however, were unsuccessful in clinical settings because of their unfavourable pharm ...
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... Quaternary ammonium compounds cause bronchodilation by blocking cholinergic contractile action. In the nasal passages, ipratropium reduces hypersecretion, the basis for its use in rhinitis. As an anticholinergic, the compound would not stimulate cholinergic sites. Quaternary ammonium compounds do no ...
... Quaternary ammonium compounds cause bronchodilation by blocking cholinergic contractile action. In the nasal passages, ipratropium reduces hypersecretion, the basis for its use in rhinitis. As an anticholinergic, the compound would not stimulate cholinergic sites. Quaternary ammonium compounds do no ...
Multiple mechanisms involved in the large-spectrum
... (THC) being able, on the contrary, to antagonize these effects. This property, together with its safety profile, was an initial stimulus for the investigation of CBD pharmacological properties. It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric di ...
... (THC) being able, on the contrary, to antagonize these effects. This property, together with its safety profile, was an initial stimulus for the investigation of CBD pharmacological properties. It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric di ...
Clinical Pharmacology of Opioids for Pain - Weill
... with persistent pain.3 One of the major conclusions derived from the experience in managing cancer pain with opioids is that the abuse potential of these drugs is low when they are used to manage cancer pain in patients without a history of substance abuse.2–4 The extent to which this observation ca ...
... with persistent pain.3 One of the major conclusions derived from the experience in managing cancer pain with opioids is that the abuse potential of these drugs is low when they are used to manage cancer pain in patients without a history of substance abuse.2–4 The extent to which this observation ca ...
Characterization of the Effects of the Partial Dopamine Agonist
... low dopamine tone such as after denervation or during functional depletion of the neurotransmitter, partial agonists show agonistic properties since their low intrinsic activity meets with a hyperresponsive receptor system (Clark et al., 1985, Pulvirenti and Koob, 1994). Several compounds with parti ...
... low dopamine tone such as after denervation or during functional depletion of the neurotransmitter, partial agonists show agonistic properties since their low intrinsic activity meets with a hyperresponsive receptor system (Clark et al., 1985, Pulvirenti and Koob, 1994). Several compounds with parti ...
ANTICONVULSANT ACTIVITY OF AQUEOUS ROOT EXTRACT OF CALOTROPIS GIGANTEA IN
... population.Its incidence in India is around 20-50 cases per lakh population.[3] Although newer and selective agents are currently used,there is still a drawback due to their side effect profile and also few cases being refractory to conventional treatment. The current study was undertaken to evaluat ...
... population.Its incidence in India is around 20-50 cases per lakh population.[3] Although newer and selective agents are currently used,there is still a drawback due to their side effect profile and also few cases being refractory to conventional treatment. The current study was undertaken to evaluat ...
Importance of NMDA Receptor Activation During Initial
... response is the product of a complex and well‐regulated set of processes in the body that assist in coping with the stress in an adaptive manner. Two endocrine systems in the body react to a stress stimulus. The sympathetic nervous system (SNS) stimulates release of epinephrine from the adrenal ...
... response is the product of a complex and well‐regulated set of processes in the body that assist in coping with the stress in an adaptive manner. Two endocrine systems in the body react to a stress stimulus. The sympathetic nervous system (SNS) stimulates release of epinephrine from the adrenal ...
Pharmacological Characterization of Noroxymorphone as a New
... BACKGROUND: Noroxymorphone is one of the major metabolites of oxycodone. Although oxycodone is commonly used in the treatment of acute and chronic pain, little is known about the antinociceptive effects of noroxymorphone. We present an in vivo pharmacological characterization of noroxymorphone in ra ...
... BACKGROUND: Noroxymorphone is one of the major metabolites of oxycodone. Although oxycodone is commonly used in the treatment of acute and chronic pain, little is known about the antinociceptive effects of noroxymorphone. We present an in vivo pharmacological characterization of noroxymorphone in ra ...
alcoholism pharmacotherapy
... Current psychosocial approaches to alcohol addiction are moderately effective, with perhaps as many as half the patients receiving treatment becoming abstinent or significantly reducing episodes of binge drinking (4). In the past two decades significant progress has been made in understanding the ph ...
... Current psychosocial approaches to alcohol addiction are moderately effective, with perhaps as many as half the patients receiving treatment becoming abstinent or significantly reducing episodes of binge drinking (4). In the past two decades significant progress has been made in understanding the ph ...
Antihistamines in pediatric allergy
... inhibition model. In the same way as in adults, no tachyphylaxis or tolerance of this effect on histamine-induced wheal and erythema production is observed.30 Adverse effects of H1 antihistamines The different national and international drug agencies admit that there are currently many medicines aut ...
... inhibition model. In the same way as in adults, no tachyphylaxis or tolerance of this effect on histamine-induced wheal and erythema production is observed.30 Adverse effects of H1 antihistamines The different national and international drug agencies admit that there are currently many medicines aut ...
Chapter 7: Anticholinergic (Parasympatholytic) Bronchodilators Test
... parasympathetic tone and may cause mucociliary slowing, bronchodilation, and increased heart rate. Parasympathetic agents decrease heart rate and cause bronchoconstriction. REF: pg. 124 OBJ: 3 LEVEL: Recall MSC: Chapter 7 Anticholinergic (Parasympatholytic) Bronchodilators 7. Quaternary ammonium com ...
... parasympathetic tone and may cause mucociliary slowing, bronchodilation, and increased heart rate. Parasympathetic agents decrease heart rate and cause bronchoconstriction. REF: pg. 124 OBJ: 3 LEVEL: Recall MSC: Chapter 7 Anticholinergic (Parasympatholytic) Bronchodilators 7. Quaternary ammonium com ...
4-aminoquinolines as Antimalarial Drugs
... otherwise, it fails to account for any interactions the protonated heterocyclic nitrogen may have. This was highlighted in a publication by O’Neill et al. (1997). In this publication, O’Neill et al. (1997) proposed that the receptor proposed by Koh et al. was in fact ferriprotoporphyrin IX since it ...
... otherwise, it fails to account for any interactions the protonated heterocyclic nitrogen may have. This was highlighted in a publication by O’Neill et al. (1997). In this publication, O’Neill et al. (1997) proposed that the receptor proposed by Koh et al. was in fact ferriprotoporphyrin IX since it ...
Dopamine and glucose, obesity, and reward deficiency syndrome
... Our laboratory has published on the concept known as Reward Deficiency Syndrome (RDS) which is a genetic and epigenetic phenomena leading to impairment of the brain reward circuitry resulting in a hypo-dopaminergic function. RDS involves the interactions of powerful neurotransmitters and results in a ...
... Our laboratory has published on the concept known as Reward Deficiency Syndrome (RDS) which is a genetic and epigenetic phenomena leading to impairment of the brain reward circuitry resulting in a hypo-dopaminergic function. RDS involves the interactions of powerful neurotransmitters and results in a ...
Structure-based design of hyaluronidase inhibitors
... As major constituent of the extracellular matrix, hyaluronan is present in the skin (about 50 % of the total HA in the body) but also in the vitreous humour of the eye (0.1-0.4 mg/g wet weight), in the synovial joint fluid (3-4 mg/ml), in the matrix produced by the cumulus cells around the oocyte pr ...
... As major constituent of the extracellular matrix, hyaluronan is present in the skin (about 50 % of the total HA in the body) but also in the vitreous humour of the eye (0.1-0.4 mg/g wet weight), in the synovial joint fluid (3-4 mg/ml), in the matrix produced by the cumulus cells around the oocyte pr ...
Biological substrates of reward and aversion: A nucleus accumbens
... and Rompré, 1989). There are three primary lines of evidence implicating the NAc in reward, involving pharmacological, molecular, and electrophysiological approaches. 3.1. Pharmacological evidence It is well established that drugs of abuse (Di Chiara and Imperato, 1988) and natural rewards (Fibiger ...
... and Rompré, 1989). There are three primary lines of evidence implicating the NAc in reward, involving pharmacological, molecular, and electrophysiological approaches. 3.1. Pharmacological evidence It is well established that drugs of abuse (Di Chiara and Imperato, 1988) and natural rewards (Fibiger ...
5-hydroxytryptamine1a-like receptor activation in the bed nucleus of
... regions are reciprocally connected (Petit et al., 1995; Vertes et al., 1994), and serotonergic axons from the dorsal raphe nucleus preferentially target neurons of the anterior BNST (Commons et al., 2003; Phelix et al., 1992a,b). Moreover, 5-HT levels increase in forebrain regions in response to str ...
... regions are reciprocally connected (Petit et al., 1995; Vertes et al., 1994), and serotonergic axons from the dorsal raphe nucleus preferentially target neurons of the anterior BNST (Commons et al., 2003; Phelix et al., 1992a,b). Moreover, 5-HT levels increase in forebrain regions in response to str ...
Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models... Is Less More? By
... An ultra-low dose of a drug is approximately 1000-fold lower than the dose range traditionally used to induce a therapeutic effect. The purpose of the present thesis was to broaden the knowledge of the ultra-low dose effect, that was previously identified in the opioid receptor system, by looking at ...
... An ultra-low dose of a drug is approximately 1000-fold lower than the dose range traditionally used to induce a therapeutic effect. The purpose of the present thesis was to broaden the knowledge of the ultra-low dose effect, that was previously identified in the opioid receptor system, by looking at ...
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... al. 2003). As a result, it acts as a D2 receptor agonist at receptor sites where dopaminergic transmission is significantly decreased while acting as an antagonist at other dopaminergic sites with normal or increased transmission. However, because of its intrinsic efficacy, it does not cause total b ...
... al. 2003). As a result, it acts as a D2 receptor agonist at receptor sites where dopaminergic transmission is significantly decreased while acting as an antagonist at other dopaminergic sites with normal or increased transmission. However, because of its intrinsic efficacy, it does not cause total b ...