PerspectiVe
... The number of commercial and academic groups actively engaged in fragment-based research has increased, and as a consequence, there has been continued development and refinement of techniques and methods. From its inception, the fragment-based approach had two central tenets that were critical to it ...
... The number of commercial and academic groups actively engaged in fragment-based research has increased, and as a consequence, there has been continued development and refinement of techniques and methods. From its inception, the fragment-based approach had two central tenets that were critical to it ...
Medications and Alcohol Craving - Assisted Recovery Centers of
... both their drinking and craving. In the study, naltrexone was administered to patients participating in an alcoholism rehabilitation program that included group therapy, individual counseling, health education, and recreation. Craving was assessed weekly by means of a single-item, 10-point scale wi ...
... both their drinking and craving. In the study, naltrexone was administered to patients participating in an alcoholism rehabilitation program that included group therapy, individual counseling, health education, and recreation. Craving was assessed weekly by means of a single-item, 10-point scale wi ...
Harm Reduction Journal
... Like many substances that are put into the human body, there can be positive or negative consequences that result from cannabis consumption, depending on amount, frequency, quality, and probably most importantly, the idiosyncratic biochemistry of the user. Prohibitionists concentrate their efforts o ...
... Like many substances that are put into the human body, there can be positive or negative consequences that result from cannabis consumption, depending on amount, frequency, quality, and probably most importantly, the idiosyncratic biochemistry of the user. Prohibitionists concentrate their efforts o ...
μ-Opioid Receptor-Mediated Depression of the Hypothalamic
... seeking (Harris et al., 2005), and the place preference and hyperlocomotion associated with morphine are attenuated in mice lacking hypocretin (Narita et al., 2006). Although these studies show that opiates influence the hypocretin system, whether this effect is direct or indirect has not been teste ...
... seeking (Harris et al., 2005), and the place preference and hyperlocomotion associated with morphine are attenuated in mice lacking hypocretin (Narita et al., 2006). Although these studies show that opiates influence the hypocretin system, whether this effect is direct or indirect has not been teste ...
Low-Dose Naltrexone (LDN)
... regulate cell growth of both normal and abnormal cells. Dr. Zagon named or re-named Met-5Enkephalin (met-enkephalin) to - opioid growth factor (OGF) to better reference its functional properties and to distinguish it from its neuromodulatory function. They also identified the receptor activated by O ...
... regulate cell growth of both normal and abnormal cells. Dr. Zagon named or re-named Met-5Enkephalin (met-enkephalin) to - opioid growth factor (OGF) to better reference its functional properties and to distinguish it from its neuromodulatory function. They also identified the receptor activated by O ...
kopia+_Eli_PR5`2006.vp:CorelVentura 7.0
... and, to a certain extent, glucose metabolism in the so-called peri-stroke region as well as in the relatively intact brain tissue [40]. Vinpocetine has been found to interfere with various stages of the ischemic cascade: adenosine triphosphate (ATP) depletion, activation of voltage-sensitive Na+- an ...
... and, to a certain extent, glucose metabolism in the so-called peri-stroke region as well as in the relatively intact brain tissue [40]. Vinpocetine has been found to interfere with various stages of the ischemic cascade: adenosine triphosphate (ATP) depletion, activation of voltage-sensitive Na+- an ...
A clickable analogue of ketamine retains NMDA receptor activity
... were significantly decreased in each of the drug treatment groups relative to vehicle controls (*p < 0.002). However, rearing duration in the A-NK-amide group was significantly greater than duration in the other drug groups (#p < 0.0005). For A-C, n = 5 mice per condition. (d1) Ketamine reduced ...
... were significantly decreased in each of the drug treatment groups relative to vehicle controls (*p < 0.002). However, rearing duration in the A-NK-amide group was significantly greater than duration in the other drug groups (#p < 0.0005). For A-C, n = 5 mice per condition. (d1) Ketamine reduced ...
List of Figures - The University of Tennessee, Knoxville
... The melanocyte is the principal cell type involved in coat color pigmentation. During embryonic development melanocyte precursors (melanoblasts) migrate from the neural tube to the base of developing hair follicles (Billingham and Silvers, 1960; Searle 1968). The melanoblasts differentiate into mela ...
... The melanocyte is the principal cell type involved in coat color pigmentation. During embryonic development melanocyte precursors (melanoblasts) migrate from the neural tube to the base of developing hair follicles (Billingham and Silvers, 1960; Searle 1968). The melanoblasts differentiate into mela ...
ii. immunosuppressive drugs - The University of Tennessee, Knoxville
... The melanocyte is the principal cell type involved in coat color pigmentation. During embryonic development melanocyte precursors (melanoblasts) migrate from the neural tube to the base of developing hair follicles (Billingham and Silvers, 1960; Searle 1968). The melanoblasts differentiate into mela ...
... The melanocyte is the principal cell type involved in coat color pigmentation. During embryonic development melanocyte precursors (melanoblasts) migrate from the neural tube to the base of developing hair follicles (Billingham and Silvers, 1960; Searle 1968). The melanoblasts differentiate into mela ...
N-Methyl-D-Aspartate Receptor Antagonist APV Blocks
... Because o f the rapidity with which it can be established and because of its longevity, LTP has been proposed as a physiological mechanism for learning and memory (Bliss & Lomo, 1973; Lynch & Baudry, 1984). N-methyl-D-aspartate (NMDA) receptors appear to play an important role in the development o f ...
... Because o f the rapidity with which it can be established and because of its longevity, LTP has been proposed as a physiological mechanism for learning and memory (Bliss & Lomo, 1973; Lynch & Baudry, 1984). N-methyl-D-aspartate (NMDA) receptors appear to play an important role in the development o f ...
Related File
... administered, resulting in 157 overdose reversals. In the 18 months before October 2010, there were 46 overdose related deaths. In the 18 months after the implementation of the Narcan program there were 22 overdose related deaths. Read more: PAUL KEENAN: The Quincy Narcan model is saving – and chang ...
... administered, resulting in 157 overdose reversals. In the 18 months before October 2010, there were 46 overdose related deaths. In the 18 months after the implementation of the Narcan program there were 22 overdose related deaths. Read more: PAUL KEENAN: The Quincy Narcan model is saving – and chang ...
Long-term lorazepam use in elderly psychiatric outpatients
... To establish whether the challenge dose (ranging from 0.5 to 3.0 mg across study subjects) was associated with the magnitude of memory and psychomotor impairments following acute lorazepam administration, we modeled the outcome at 2.5 hours (i.e., time of peak effect) as a function of treatment, ch ...
... To establish whether the challenge dose (ranging from 0.5 to 3.0 mg across study subjects) was associated with the magnitude of memory and psychomotor impairments following acute lorazepam administration, we modeled the outcome at 2.5 hours (i.e., time of peak effect) as a function of treatment, ch ...
BIOLOGICAL EVALUATION OF OPIOIDS, STIMULANTS, AND
... increase on adding the cinnamyl group – a 44,000-fold increase in potency in the anti-writhing assay. Although this is an important finding, it should be noted that NIH 11131, the 14-methoxy analog, also had potent antinociceptive activity. NIH 11134 and NIH 11137 both contain a 3,4-dimethoxy substi ...
... increase on adding the cinnamyl group – a 44,000-fold increase in potency in the anti-writhing assay. Although this is an important finding, it should be noted that NIH 11131, the 14-methoxy analog, also had potent antinociceptive activity. NIH 11134 and NIH 11137 both contain a 3,4-dimethoxy substi ...
oxycodone/naloxone controlled release
... is a mu opioid receptor agonist that provides analgesic relief. Naloxone is an opioid receptor antagonist, added to counteract oxycodone-induced constipation. Naloxone has limited oral systemic bioavailability; its effect is limited to the gastrointestinal tract and, as such, it will not induce opio ...
... is a mu opioid receptor agonist that provides analgesic relief. Naloxone is an opioid receptor antagonist, added to counteract oxycodone-induced constipation. Naloxone has limited oral systemic bioavailability; its effect is limited to the gastrointestinal tract and, as such, it will not induce opio ...
Unusual interactions of benzodiazepine receptor antagonists David
... the opposite effect to BDZs,“ Flumazenil „seems to be a selective & potent antagonist of both compounds in both systems having any detectable effect of its own. (...; it) seems to be selective for (...) BDZ receptor.“ 22/x ...
... the opposite effect to BDZs,“ Flumazenil „seems to be a selective & potent antagonist of both compounds in both systems having any detectable effect of its own. (...; it) seems to be selective for (...) BDZ receptor.“ 22/x ...
Neural mechanisms underlying morphine withdrawal in addicted
... by repeated application is a major concern in pain therapy. It was shown that combined treatment of nalbuphine with morphine affects the development of tolerance and dependence on morphine. The use of nalbuphine, kappa-agonist may be a useful adjunct therapy for prevention of morphine-induced undesi ...
... by repeated application is a major concern in pain therapy. It was shown that combined treatment of nalbuphine with morphine affects the development of tolerance and dependence on morphine. The use of nalbuphine, kappa-agonist may be a useful adjunct therapy for prevention of morphine-induced undesi ...
Laurate Biosensors Image Brain Neurotransmitters In Vivo: Can an Antihypertensive Medication Alter Psychostimulant Behavior?
... behaviors. The specific open-field behaviors studied were: locomotion (forward ambulatory motion), stereotypy (repeated grooming motion, also called fine movements) and central locomotion (forward ambulatory motion in the central part of the chamber, indicating reduced anxiety). Thus, NMI provides a ...
... behaviors. The specific open-field behaviors studied were: locomotion (forward ambulatory motion), stereotypy (repeated grooming motion, also called fine movements) and central locomotion (forward ambulatory motion in the central part of the chamber, indicating reduced anxiety). Thus, NMI provides a ...
fullcvenglish_tmavromous
... Inhibitors through Molecular Docking Studies. J. Mol. Gr. Mod. 29 425-435 (2010) by A.P. Politi, S. Durdagi, P.M. Minakakis, T. Mavromoustakos, G. Kokotos was elected by the journal as one of the 25 best articles between October-December 2010. http://top25.sciencedirect.com/subject/pharmacology-toxi ...
... Inhibitors through Molecular Docking Studies. J. Mol. Gr. Mod. 29 425-435 (2010) by A.P. Politi, S. Durdagi, P.M. Minakakis, T. Mavromoustakos, G. Kokotos was elected by the journal as one of the 25 best articles between October-December 2010. http://top25.sciencedirect.com/subject/pharmacology-toxi ...
Interactive Association of Drugs Binding to Human
... metals and toxic metabolites [1–6]. Additionally, there is a wide variety of drugs that are delivered to their targeting organs/tissues by binding with HSA [1,7–9]. Therefore, HSA not only protects the bound drugs against oxidation and influences the in vivo drug distribution, but also alters the ph ...
... metals and toxic metabolites [1–6]. Additionally, there is a wide variety of drugs that are delivered to their targeting organs/tissues by binding with HSA [1,7–9]. Therefore, HSA not only protects the bound drugs against oxidation and influences the in vivo drug distribution, but also alters the ph ...
The Glycine Transporter-1 Inhibitor SSR103800 Displays a
... increased the PPI of the startle reflex in DBA/1J mice and increased latent inhibition (LI) in untreated controls, while reversing amphetamine-disrupted LI as well as abnormally persistent LI induced by MK-801 (Black et al, 2008). This study aimed at investigating further the potential antipsychotic ...
... increased the PPI of the startle reflex in DBA/1J mice and increased latent inhibition (LI) in untreated controls, while reversing amphetamine-disrupted LI as well as abnormally persistent LI induced by MK-801 (Black et al, 2008). This study aimed at investigating further the potential antipsychotic ...
Pharmacology
... D. It is more potent as an antipsychotic drug than is chlorhyperphagic and complained that her limbs felt heavy. promazine An initial diagnosis was made of a major depressive E. It produces a lower incidence of extrapyramidal reacdisorder with atypical symptoms. Treatment was tions than does chlorpr ...
... D. It is more potent as an antipsychotic drug than is chlorhyperphagic and complained that her limbs felt heavy. promazine An initial diagnosis was made of a major depressive E. It produces a lower incidence of extrapyramidal reacdisorder with atypical symptoms. Treatment was tions than does chlorpr ...
RESPIRATORY-FINAL
... -For example , cough may be the first or only symptom in bronchial asthma or allergy, and in such cases bronchodilators(e.g., 2 – adrenergic receptor agonists have been shown to reduce cough ) without having any significant central effects, other drugs act primarily on the central or the peripheral ...
... -For example , cough may be the first or only symptom in bronchial asthma or allergy, and in such cases bronchodilators(e.g., 2 – adrenergic receptor agonists have been shown to reduce cough ) without having any significant central effects, other drugs act primarily on the central or the peripheral ...
Nicotine and the adolescent brain
... purchased by minors in many states (Paradise, 2014). There is a substantial literature that shows nicotine to be a neuroteratogen that exerts long-term, maturational effects at critical stages of brain development (Slotkin, 2004; Ginzel et al. 2007; Dwyer et al. 2008, 2009). As discussed in the pres ...
... purchased by minors in many states (Paradise, 2014). There is a substantial literature that shows nicotine to be a neuroteratogen that exerts long-term, maturational effects at critical stages of brain development (Slotkin, 2004; Ginzel et al. 2007; Dwyer et al. 2008, 2009). As discussed in the pres ...
Nausea and vomiting after surgery
... Three other serotonin antagonists, namely granisetron, dolasetron, and palonosetron, have a similar efficacy and side-effect profile (e.g. constipation, headache) to ondansetron. Like droperidol, ondansetron, granisetron, and dolasetron are associated with QTc prolongation, which increases the risk ...
... Three other serotonin antagonists, namely granisetron, dolasetron, and palonosetron, have a similar efficacy and side-effect profile (e.g. constipation, headache) to ondansetron. Like droperidol, ondansetron, granisetron, and dolasetron are associated with QTc prolongation, which increases the risk ...
Selective Inhibitors of Picornavirus Replication
... Numerous studies have been performed in the past decades on a series of compounds developed by Sterling-Winthrop, commonly known as ‘‘WIN compounds.’’ Following lead optimization of an accidentally discovered compound, a drug was developed that would meet most of the criteria of a successful anti-pi ...
... Numerous studies have been performed in the past decades on a series of compounds developed by Sterling-Winthrop, commonly known as ‘‘WIN compounds.’’ Following lead optimization of an accidentally discovered compound, a drug was developed that would meet most of the criteria of a successful anti-pi ...