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Health Canada
Santé Canada
STATUS DECISION OF CONTROLLED
AND NON-CONTROLLED SUBSTANCE(S)
Substance: Dermorphin
Based on the current information available to the Office of Controlled Substances, it appears that
the above substance is:
Controlled
Not Controlled
☐
X
under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following
reason(s):

The substance is not structurally similar to any of those included in the Schedules to the
CDSA.
Prepared by: _______________________________________
Vincent Marleau
Date: _______________
Verified by:
Date: ________________
_______________________________________
Manager, NCED, OCS
Approved by: _______________________________________
Date: ________________
DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES
This status was requested by: Finola Francis, HPFB
2
Drug Status Report
Drug: Dermorphin
Drug Name Status: Dermorphin is the common name.
Chemical Name: H-Tyr-D-ala-phe-gly-tyr-pro-ser-NH2
Other Names: (S)-N-((S)-1-Amino-3-hydroxy-1-oxopropan-2-yl)-1-((2S,8S,11R,14S)-14amino-8-benzyl-2-(4-hydroxybenzyl)-15-(4-hydroxyphenyl)-11-methyl-4,7,10,13-tetraoxo3,6,9,12-tetraazapentadecan-1-oyl)pyrrolidine-2-carboxamide; Tyrosyl-D-alanyl-phenylalanylglycyl-tyrosyl-prolyl-serinamide; H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2.
Chemical structure:
Molecular Formula: C40H50N8O10
CAS-RN: 77614-16-5
Pharmacological class / Application: Analgesic
International status:
US: Dermorphin is not listed specifically in the Schedules to the US Controlled Substances Act
and is not mentioned anywhere on the DEA website.
United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under
International Control, the Green List - List of Psychotropic Substances under International
Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit
Manufacture of Narcotic Drugs and Psychotropic Substances under International Control.
Canadian Status: Dermorphin is not listed in the Schedules to the CDSA. The substance,
isolated from frog skin, is a peptide that has shown to display opioid-like activity.1,2 This
substance is not structurally similar to any of the substances listed in the Schedules to the CDSA.
Recommendation: Dermorphin is not included in the Schedules to the CDSA and is not a
controlled substance.
Date: January 8th, 2014.
1
Broccardo, M. et al(1981). Pharmacological data on dermorphins, a new class of potent opioid peptides from
amphibian skin. Br. J. Pharmacol. 73(3): 625-631.
2
Richter, K. et al(1987). D-Alanine in the Frog Skin Peptide Dermorphin is Derived from L-Alanine in the
Precursor. Science. 238 (4824) : 200-202.