File - the Drug Card Database
... daily in patients who are receiving diuretics or are volume depleted. Patients with Type 2 diabetic
nephropathy--300 mg once daily.
Action: Blocks vasoconstrictor and aldosterone-producing effects of angiotensin II at receptor sites,
including vascular smooth muscle and the adrenal glands.
... 4. ACE inhibitors are fetotoxic and should not be used by
women who are pregnant.
Discovery and development of angiotensin receptor blockers
The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare].ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy.The discovery and development of ARBs is a demonstrative example of modern rational drug design and how design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.