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34th ECDD 2006/5 gamma-hydroxybutyric acid (GHB)
34th ECDD 2006/5 gamma-hydroxybutyric acid (GHB)

XP13512 [()-1-([(α-Isobutanoyloxyethoxy
XP13512 [()-1-([(α-Isobutanoyloxyethoxy

Bioavailability & Bioequivalence
Bioavailability & Bioequivalence

Enhancing the Delivery of Resveratrol in Humans
Enhancing the Delivery of Resveratrol in Humans

ibogaine: a review
ibogaine: a review

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Inhibitio¡ of GLutathione S-Õransferases Studies

GHB, GBL and 1,4-BD Addiction - Trimbos
GHB, GBL and 1,4-BD Addiction - Trimbos

... (partially) replace other substances. These studies can also be used to uncover common mechanistic pathways. Selective GABAB antagonism diminished these discriminative stimulus effects, whereas antagonists of the GHB receptor did not. However, the difference in effects between baclofen and GHB has l ...
Pharmacology of platelet inhibition in humans: implications of the
Pharmacology of platelet inhibition in humans: implications of the

... ABSTRACT The current dispute over the effects of "low" vs "high"doses of aspirin should take into consideration the pharmacokinetics of this drug. In fact, different pharmaceutical formulations of aspirin may deliver little or no aspirin to the systemic blood. This was the case, for instance, in hea ...
Adenine Nucleotides Undergo Rapid, Quantitative Conversion to
Adenine Nucleotides Undergo Rapid, Quantitative Conversion to

IDENTIFICATION OF NATURAL PRODUCTS AS ANTIDIABETIC AGENTS Laura Guasch Pàmies
IDENTIFICATION OF NATURAL PRODUCTS AS ANTIDIABETIC AGENTS Laura Guasch Pàmies

Full Product Information
Full Product Information

Potential medicinal benefits of Cosmos caudatus (Ulam Raja): A
Potential medicinal benefits of Cosmos caudatus (Ulam Raja): A

ERGOLINE ALKALOIDS ERGOT ALKALOIDS ÇAVDAR MAHMUZU
ERGOLINE ALKALOIDS ERGOT ALKALOIDS ÇAVDAR MAHMUZU

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week5

BAX 855, a PEGylated rFVIII product with prolonged half-life
BAX 855, a PEGylated rFVIII product with prolonged half-life

Tobacco Smoking and Nicotine Neuropsychopharmacology
Tobacco Smoking and Nicotine Neuropsychopharmacology

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2009 St Johns Wort Quality Issues and Active Compounds

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Advances in and applications of proteasome inhibitors

Reviews Essential Tremor - Tremor and Other Hyperkinetic
Reviews Essential Tremor - Tremor and Other Hyperkinetic

... hyperpolarization. Different benzodiazepines have somewhat different affinities for different pentamer combinations but clinical tremor comparisons among benzodiazepines lack adequate fidelity to correlate these. TPA023, a GABA-A alpha-2, three subtype-selective partial agonist, did show relatively ...
Exploitation of Bile Acid Transport Systems in Prodrug Design
Exploitation of Bile Acid Transport Systems in Prodrug Design

SLCO1B1 polymorphism markedly affects the pharmacokinetics of
SLCO1B1 polymorphism markedly affects the pharmacokinetics of

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The Role of Corticotropin-Releasing Factor in Drug Addiction

Gamma Hydroxybutyric Acid (GHB) Intoxication Abstract 730
Gamma Hydroxybutyric Acid (GHB) Intoxication Abstract 730

Dynorphin A1–13 Stimulates Ovine Fetal Pituitary
Dynorphin A1–13 Stimulates Ovine Fetal Pituitary

NIH Public Access - The Scripps Research Institute
NIH Public Access - The Scripps Research Institute

... In 2002, the first X-ray crystal structure of FAAH was determined for the rat enzyme at 2.8 À resolution using ΔTM-rFAAH in complex with an irreversible inhibitor, methyl arachidonyl fluorophosphonate (MAFP) (52). FAAH crystallized as a dimeric enzyme, consistent with chemical cross-linking and anal ...
1 2 3 4 5 ... 85 >

Discovery and development of angiotensin receptor blockers

The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare].ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy.The discovery and development of ARBs is a demonstrative example of modern rational drug design and how design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.
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