• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Abstract Ethnopharmacological relevance Achillea millefolium L
Abstract Ethnopharmacological relevance Achillea millefolium L

... into and time spent on the open arms, at doses that do not affect locomotor activity (Lister, 1987 and Borsini et al., 2002). However, debatable is whether the elevated plus maze can detect the anxiolytic-like effects of antidepressants, such as selective serotonin reuptake inhibitors (Rodgers and C ...
Targeting proteases: successes, failures and future prospects
Targeting proteases: successes, failures and future prospects

... Development of the current generation of ACE inhibitors (FIG. 2b) is a special story, because 30 years ago neither the sequence nor three-dimensional structure of the enzyme was available. Instead, the structure of carboxypeptidase A, now known to be considerably different from that of ACE, was used ...
[Salvia divinorum - a potential drug for abuse]
[Salvia divinorum - a potential drug for abuse]

... humans (Siebert DJ, 1994). Additionally, given that its pharmacological action (kappa-opioid receptor agonist) is quite unique compared to other hallucinogens (some of which act via the serotonin 5-HT receptor), salvinorin A's long-term effects remain to be established. Therefore, the risks of Salvi ...
3. Results
3. Results

Antidote–Opioids
Antidote–Opioids

Docking and Ligand Binding Affinity: Uses and Pitfalls
Docking and Ligand Binding Affinity: Uses and Pitfalls

... predict the structure of the intermolecular complex formed between two or more constituent molecules, trying to predict the position and orientation of a ligand (a small molecule) when it is bound to a protein in order to know the predominant binding mode(s) of a ligand with a protein of known three ...
Side Effects of Anabolic Androgenic Steroids
Side Effects of Anabolic Androgenic Steroids

pharmacology basic principles
pharmacology basic principles

... SA of GI tract, mixing of contents, pH differences at different levels; can be destroyed by acid (eg. Some penicillins) and enzymes (eg. Insulin is hydrolysed) and microbial activity INH: can be used from agents that vaporize easily (eg. Amyl nitrite) or can be dispersed in aqueous droplets (eg. Erg ...


I The 1982 John
I The 1982 John

ESC 2003
ESC 2003

Elicited hippocampal theta rhythm: a screen for anxiolytic and
Elicited hippocampal theta rhythm: a screen for anxiolytic and

... presence of these gating systems is important for our understanding of the different effects that can be obtained with elicitation of theta from different ascending systems. Stimulation of ascending cholinergic systems can elicit clear theta; but increasing levels of stimulation have a very modest e ...
Cox-2-Selective Inhibitors: The New Super Aspirins
Cox-2-Selective Inhibitors: The New Super Aspirins

... properties. Although many of the 1,5-diarylpyrazoles that possessed 5(4-halophenyl) substituents (e.g., SC58128 and SC588; Fig. 1) had good selectivity and in vivo activity, they also possessed unacceptably long in vivo half-lives (.100 h) (Penning et al., 1997). Substitution of the 5(4-halophenyl) ...
Review Advances in nucleoside monophosphate prodrugs as anti
Review Advances in nucleoside monophosphate prodrugs as anti

... As discussed earlier, some nucleoside analogues have poor cell permeability and/or are not suitable substrates for cellular kinases, which transform it to the biologically active NTP. This problem can be alleviated by the use of a substituted MP prodrug strategy that would be converted, initially, t ...
09107sgp04
09107sgp04

... transient effects that resolved with regular dosing. In dogs, heart rate increases were greater after co-administration than after salmeterol alone. ...
Study of the interaction between 3,4- methylenedioximethamphetamine and the endocannabinoid system
Study of the interaction between 3,4- methylenedioximethamphetamine and the endocannabinoid system

Pharmacokinetics and pharmacodynamics of oral oxycodone in
Pharmacokinetics and pharmacodynamics of oral oxycodone in

... O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent ␮-opioid ligand, with 2 to 5 times higher ␮-opioid receptor affinity and in vivo analgesic potency than morphine.8 –11 However, recent data showed th ...
Role of Mu- and Delta-Opioid Receptors in the
Role of Mu- and Delta-Opioid Receptors in the

... reinstatement of cocaine seeking, and intra-NAc morphine infusions induce a conditioned place preference (van der Kooy et al, 1982). Opioid receptors are highly expressed by NAc neurons (Mansour et al, 1995, 1987), and local opioid infusions in the NAc modulate behavior in a biphasic manner. Thus, m ...
Unusual interactions of benzodiazepine receptor antagonists David
Unusual interactions of benzodiazepine receptor antagonists David

Salvia divinorum and Salvinorin A: An Update on Pharmacology and
Salvia divinorum and Salvinorin A: An Update on Pharmacology and

... A further study evaluated the effect of products of the in vitro autoxidation of salvinorin A. The main product of the neutral fraction after basic cleavage with 1 M KOH in methanol was an enedione. The major product in the base-soluble fraction was the 1,2-secotriester. Both the enedione and 1,2-se ...
Liver X Receptor Agonists as Potential Therapeutic Agents for
Liver X Receptor Agonists as Potential Therapeutic Agents for

... molecule ligand, such as estradiol for the estrogen receptor, to a nuclear receptor modulates transcription of target genes through the binding of the nuclear receptor/ligand complex to appropriate response elements in the proximal promoter of target genes. The nuclear receptors LXR␣ (NR1H3) and LXR ...
Unit Assessment Keyed for Instructors
Unit Assessment Keyed for Instructors

Pharmacologically Active Drug Metabolites: Impact on Drug
Pharmacologically Active Drug Metabolites: Impact on Drug

Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models... Is Less More? By
Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models... Is Less More? By

The  leukotriene-receptor  antagonist  MK-0679
The leukotriene-receptor antagonist MK-0679

< 1 2 3 4 5 6 7 ... 85 >

Discovery and development of angiotensin receptor blockers

The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare].ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy.The discovery and development of ARBs is a demonstrative example of modern rational drug design and how design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report