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prediction of “first dose in human”
prediction of “first dose in human”

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Potential role of N-methyl-D-aspartate receptors as executors of

... Wilcock et al., 2002; Reisberg et al., 2003; Tariot et al., 2004; Gauthier et al., 2005; Reisberg et al., 2006). In general, published and unpublished data indicate that at therapeutic doses (typically 20–30 mg/day), at steadystate (chronic treatment for several weeks), plasma levels of memantine ar ...
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... Pharmacia-ASPET Award Jerry J. Buccafusco, Ph.D., Director of the Alzheimer’s Research Center, Professor of Pharmacology at the Medical College of Georgia, and Director of the Neuropharmacology Laboratory at the Charlie Norwood Veterans Administration Medical Center in Augusta, Georgia, is the recip ...
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Central Nervous System Mechanisms Involving GABA Influence

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... 9. The answer is В (Atenolol): Drugs which are lipid in-soluble, do not cross blood brain barrier. Three β-blockers are lipid insoluble:  Atenolol;  Nadolol;  Sotalol. All of these three share certain common characteristics which are frequently asked: — do not cross blood brain barrier and theref ...
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100 Essential Drugs - University of Toledo

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Psilocybin links binocular rivalry switch rate to attention and

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Discovery and development of angiotensin receptor blockers

The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure. Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare].ARBs are widely used drugs in the clinical setting today, their main indications being mild to moderate hypertension, chronic heart failure, secondary stroke prevention and diabetic nephropathy.The discovery and development of ARBs is a demonstrative example of modern rational drug design and how design can be used to gain further knowledge of physiological systems, in this case, the characterization of the subtypes of Ang II receptors.
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