Heart Glucocorticoids Activate Cardiac Mineralocorticoid Receptors
... proapoptotic effect of aldosterone is mimicked by cortisol (Figure 5B), with low physiological levels of glucocorticoid having a notable effect. Both spironolactone and Tempol prevented the proapoptotic effects of aldosterone and cortisol, and RU486 did not significantly alter the cortisol effect. T ...
... proapoptotic effect of aldosterone is mimicked by cortisol (Figure 5B), with low physiological levels of glucocorticoid having a notable effect. Both spironolactone and Tempol prevented the proapoptotic effects of aldosterone and cortisol, and RU486 did not significantly alter the cortisol effect. T ...
Functional Group Characteristics and Roles
... bethanchol offers several advantages for bethanechol over acetylcholine as acetylcholine non-selectively interacts with both muscarinic and nicotinic receptors, is rapidly metabolized by acetylcholinesterase, and is not orally active. The additional methyl group in bethanechol allows it to selective ...
... bethanchol offers several advantages for bethanechol over acetylcholine as acetylcholine non-selectively interacts with both muscarinic and nicotinic receptors, is rapidly metabolized by acetylcholinesterase, and is not orally active. The additional methyl group in bethanechol allows it to selective ...
Pharmacotherapy for Smoking Cessation
... brain varenicline is a competitive antagonist with more affinity for the 42 receptor than nicotine ...
... brain varenicline is a competitive antagonist with more affinity for the 42 receptor than nicotine ...
Pharmacology of anabolic steroids
... elderly, but nevertheless their efficacy still needs to be demonstrated in terms of improved physical function and quality of life. In sport, these agents are performance enhancers, this being particularly apparent in women, although there is a high risk of virilization despite the favourable myotro ...
... elderly, but nevertheless their efficacy still needs to be demonstrated in terms of improved physical function and quality of life. In sport, these agents are performance enhancers, this being particularly apparent in women, although there is a high risk of virilization despite the favourable myotro ...
D.2 Aspirin and Penicillin
... • ASPIRIN AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID) SUCH AS IBUPROFEN ARE MILD ANALGESICS. • THEY ACT BY INHIBITING THE PRODUCTION OF PROSTAGLANDINS FROM THE SITE OF INJURY, WHICH LOWERS THE INFLAMMATION, THE FEVER AND THE PAIN. • BECAUSE THE ANALGESICS DO NOT INTERFERE WITH THE FUNCTIONING ...
... • ASPIRIN AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID) SUCH AS IBUPROFEN ARE MILD ANALGESICS. • THEY ACT BY INHIBITING THE PRODUCTION OF PROSTAGLANDINS FROM THE SITE OF INJURY, WHICH LOWERS THE INFLAMMATION, THE FEVER AND THE PAIN. • BECAUSE THE ANALGESICS DO NOT INTERFERE WITH THE FUNCTIONING ...
Calcium and Beta Receptor Antagonist Overdose
... 4 L/kg.12 The more lipid soluble compounds require hepatic biotransformation prior to secretion and can therefore accumulate with hepatic insufficiency. In contrast, the water-soluble compounds are excreted by the kidney and can accumulate with renal insufficiency. Esmolol is water soluble but does ...
... 4 L/kg.12 The more lipid soluble compounds require hepatic biotransformation prior to secretion and can therefore accumulate with hepatic insufficiency. In contrast, the water-soluble compounds are excreted by the kidney and can accumulate with renal insufficiency. Esmolol is water soluble but does ...