From Medscape General Medicine
... It has been suggested that the steady rise in the incidence of cancer in developed countries during the last 100 years is caused by the routine, artificial extension of the photoperiod by electric lights, or "light pollution."[40] A long photoperiod results in depressed melatonin secretion during th ...
... It has been suggested that the steady rise in the incidence of cancer in developed countries during the last 100 years is caused by the routine, artificial extension of the photoperiod by electric lights, or "light pollution."[40] A long photoperiod results in depressed melatonin secretion during th ...
ibogaine: a review
... medicinal and ceremonial agent in West Central Africa, has been alleged to be effective in the treatment of drug abuse. The National Institute on Drug Abuse (NIDA) has given significant support to animal research, and the U.S. Food and Drug Administration (FDA) has approved Phase I studies in humans ...
... medicinal and ceremonial agent in West Central Africa, has been alleged to be effective in the treatment of drug abuse. The National Institute on Drug Abuse (NIDA) has given significant support to animal research, and the U.S. Food and Drug Administration (FDA) has approved Phase I studies in humans ...
Medical Applications and Toxicities of Gallium Compounds
... While the clinical efficacy of continuous infusion gallium nitrate has been examined in a number of different malignancies, this drug has displayed its strongest antineoplastic activity in the treatment of non-Hodgkin’s lymphoma and bladder cancer. At least 4 separate clinical trials have demonstrat ...
... While the clinical efficacy of continuous infusion gallium nitrate has been examined in a number of different malignancies, this drug has displayed its strongest antineoplastic activity in the treatment of non-Hodgkin’s lymphoma and bladder cancer. At least 4 separate clinical trials have demonstrat ...
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... wells of a 96 well microtiter plate containing final concentrations (9.375–300 µg/mL) of artesunate, artemisinin, and anti-Mtb first-line drugs (1.25–5 µg/mL), and growth controls containing no anti-Mtb first-line drugs and blank controls without inoculation were also included. The 96 well-plates, c ...
... wells of a 96 well microtiter plate containing final concentrations (9.375–300 µg/mL) of artesunate, artemisinin, and anti-Mtb first-line drugs (1.25–5 µg/mL), and growth controls containing no anti-Mtb first-line drugs and blank controls without inoculation were also included. The 96 well-plates, c ...
PDF - Theranostics
... mRNA translation. Through these processes, it compromises gene expression and regulates gene activity. It has not only become a powerful experimental tool for scientific research, but also provides a new approach to drug discovery and development [1, 2]. Almost 30 small interfering RNA (siRNA)-based ...
... mRNA translation. Through these processes, it compromises gene expression and regulates gene activity. It has not only become a powerful experimental tool for scientific research, but also provides a new approach to drug discovery and development [1, 2]. Almost 30 small interfering RNA (siRNA)-based ...
A review on pharmacological property of Mimusops elengi Linn.
... The practices of traditional medicine are based on hundreds of years of belief and observations and analysis, which help in the development of modern medicine. Today, there is widespread interest in herbal drugs [1]. Plants have been used in a number of systems of medicines in our country as well as ...
... The practices of traditional medicine are based on hundreds of years of belief and observations and analysis, which help in the development of modern medicine. Today, there is widespread interest in herbal drugs [1]. Plants have been used in a number of systems of medicines in our country as well as ...
Targeting Trace Mineral Bioavailability: The Case of Selenium
... body, which is not ideal. L-(+)-Selenomethionine is the preferred form of selenium supplementation due to its inherent safety and its scientific recognition as a bioavailable form of selenium. L-(+)Selenomethionine is unique in that it is a single chemical entity containing molecularly integrated se ...
... body, which is not ideal. L-(+)-Selenomethionine is the preferred form of selenium supplementation due to its inherent safety and its scientific recognition as a bioavailable form of selenium. L-(+)Selenomethionine is unique in that it is a single chemical entity containing molecularly integrated se ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent -opioid ligand, with 2 to 5 times higher -opioid receptor affinity and in vivo analgesic potency than morphine.8 –11 However, recent data showed th ...
... O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent -opioid ligand, with 2 to 5 times higher -opioid receptor affinity and in vivo analgesic potency than morphine.8 –11 However, recent data showed th ...
NCCT2005 - That Crazy Pharmacist
... This is not to imply that these natural compounds have been clinically proven to inhibit cancer. Multiple human trials will be needed for that. What matters is that the preclinical information presented here, as well as data from the human trials, is promising. And the most crucial point, central to ...
... This is not to imply that these natural compounds have been clinically proven to inhibit cancer. Multiple human trials will be needed for that. What matters is that the preclinical information presented here, as well as data from the human trials, is promising. And the most crucial point, central to ...
Boik-Natural-Compounds-in-Cancer-Therapy-Promising
... This is not to imply that these natural compounds have been clinically proven to inhibit cancer. Multiple human trials will be needed for that. What matters is that the preclinical information presented here, as well as data from the human trials, is promising. And the most crucial point, central to ...
... This is not to imply that these natural compounds have been clinically proven to inhibit cancer. Multiple human trials will be needed for that. What matters is that the preclinical information presented here, as well as data from the human trials, is promising. And the most crucial point, central to ...
Duloxetine Inhibits Effects of MDMA (``Ecstasy``) In Vitro and in
... effects of 3,4–methylenedioxy-methamphetamine (MDMA, ecstasy) in vitro and in 16 healthy subjects. The clinical study used a double-blind, randomized, placebo-controlled, four-session, crossover design. In vitro, duloxetine blocked the release of both 5-HT and NE by MDMA or by its metabolite 3,4-met ...
... effects of 3,4–methylenedioxy-methamphetamine (MDMA, ecstasy) in vitro and in 16 healthy subjects. The clinical study used a double-blind, randomized, placebo-controlled, four-session, crossover design. In vitro, duloxetine blocked the release of both 5-HT and NE by MDMA or by its metabolite 3,4-met ...
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... Figure 1. Locomotion assay to identify drugs that rescue the scn1Lab mutant epilepsy phenotype. a, Schematic of the phenotypebased screening process. Chemical libraries can be coded and aliquoted in small volumes (75 L) into individual wells containing one mutant fish. The 96-well microplate is arr ...
... Figure 1. Locomotion assay to identify drugs that rescue the scn1Lab mutant epilepsy phenotype. a, Schematic of the phenotypebased screening process. Chemical libraries can be coded and aliquoted in small volumes (75 L) into individual wells containing one mutant fish. The 96-well microplate is arr ...
PRODUCT MONOGRAPH PrADRIAMYCIN® PFS* doxorubicin
... anthracyclines or anthracenediones and concomitant use of drugs with the ability to suppress cardiac contractility or cardiotoxic drugs. Anthracyclines including doxorubicin should not be administered in combination with other cardiotoxic agents unless the patient’s cardiac function is closely monit ...
... anthracyclines or anthracenediones and concomitant use of drugs with the ability to suppress cardiac contractility or cardiotoxic drugs. Anthracyclines including doxorubicin should not be administered in combination with other cardiotoxic agents unless the patient’s cardiac function is closely monit ...
Synthesis and Evaluation of Antifungal Activity of Benzothiazole
... antimicrobial2, antitubercular3, anticancer4, anticonvulsant5, anthelmintic6, analgesic7 and antiinflammatory8 activities. The benzothiazole ring is present in various marine or terrestrial natural compounds, which have useful biological activities. Heterocycles containing the thiazole moiety are pr ...
... antimicrobial2, antitubercular3, anticancer4, anticonvulsant5, anthelmintic6, analgesic7 and antiinflammatory8 activities. The benzothiazole ring is present in various marine or terrestrial natural compounds, which have useful biological activities. Heterocycles containing the thiazole moiety are pr ...
Neuropharmacology of N,N-dimethyltryptamine
... 1.1. Recreational use of DMT Most hallucinogens such as lysergic acid diethylamide (LSD) and 2,5-dimethoxy-4- methylamphetamine (DOM) cause sensory distortion, depersonalization at high doses, and at least one (N,Ndiisopropyltryptamine, DiPT) causes auditory distortions, whereas some compounds such ...
... 1.1. Recreational use of DMT Most hallucinogens such as lysergic acid diethylamide (LSD) and 2,5-dimethoxy-4- methylamphetamine (DOM) cause sensory distortion, depersonalization at high doses, and at least one (N,Ndiisopropyltryptamine, DiPT) causes auditory distortions, whereas some compounds such ...
Synthetic cannabinoids in herbal products
... 1 Introduction and chemistry of synthetic cannabinoids ....................................................................................... 3 1.1 Emergence of synthetic cannabinoids in herbal products ................................................................................ 3 1.2 Defini ...
... 1 Introduction and chemistry of synthetic cannabinoids ....................................................................................... 3 1.1 Emergence of synthetic cannabinoids in herbal products ................................................................................ 3 1.2 Defini ...
Platelet inhibitory activity and pharmacokinetics of prasugrel
... platelet ADP receptor [8]. Where approved, clopidogrel is the thienopyridine of choice due to its more favorable safety profile compared to ticlopidine. The effectiveness of clopidogrel reflects its ability to block platelet activation and aggregation induced by platelet-derived ADP released at site ...
... platelet ADP receptor [8]. Where approved, clopidogrel is the thienopyridine of choice due to its more favorable safety profile compared to ticlopidine. The effectiveness of clopidogrel reflects its ability to block platelet activation and aggregation induced by platelet-derived ADP released at site ...
Dynorphin A1–13 Stimulates Ovine Fetal Pituitary
... immunoreactive-ACTH was seen after the same dose of dynorphin A1–17 (P 5 .02) but not dynorphin A2–17. This ACTH response to dynorphin A1–13 was shown to be insensitive to the opioid antagonist, naloxone (12 mg/hr), as well as antagonists of corticotropin releasing factor and arginine vasopressin. T ...
... immunoreactive-ACTH was seen after the same dose of dynorphin A1–17 (P 5 .02) but not dynorphin A2–17. This ACTH response to dynorphin A1–13 was shown to be insensitive to the opioid antagonist, naloxone (12 mg/hr), as well as antagonists of corticotropin releasing factor and arginine vasopressin. T ...
Which neuroreceptors mediate the subjective effects of MDMA in
... Brauer and de Wit (1997) found that the D2 antagonist pimozide had only little effect on amphetamineinduced elation, euphoria or vigour despite its reducing these ratings, compared with placebo, when given alone. Despite these disparities, these studies provide some evidence that dopaminergic D2 rec ...
... Brauer and de Wit (1997) found that the D2 antagonist pimozide had only little effect on amphetamineinduced elation, euphoria or vigour despite its reducing these ratings, compared with placebo, when given alone. Despite these disparities, these studies provide some evidence that dopaminergic D2 rec ...
TECTONA GRANDIS Research Article NEHA KHERA
... radiation. The change in the T/C ration was concentration and dose dependent. There was significant change in the percentage of body weight [38]. Anti-metastatic activity Metastasis is the major process responsible for the death in cancer patients[39]. The literature survey has revealed that the lap ...
... radiation. The change in the T/C ration was concentration and dose dependent. There was significant change in the percentage of body weight [38]. Anti-metastatic activity Metastasis is the major process responsible for the death in cancer patients[39]. The literature survey has revealed that the lap ...
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... CRC (HR, 0.41; 95% CI, 0.17–1.00, p=0.05), beginning five years after the initiation of aspirin treatment. Finally, Last, in the two largest RCTs performed on healthy individuals [The Physicians’s Health (PHS) and Women’s Health (WHS) Studies], aspirin (325 and 100 mg, respectively) did not signific ...
... CRC (HR, 0.41; 95% CI, 0.17–1.00, p=0.05), beginning five years after the initiation of aspirin treatment. Finally, Last, in the two largest RCTs performed on healthy individuals [The Physicians’s Health (PHS) and Women’s Health (WHS) Studies], aspirin (325 and 100 mg, respectively) did not signific ...
AMERICAN ACADEMY OF PEDIATRICS Adolescents and Anabolic
... aminotransferase, alanine aminotransferase, and lactate dehydrogenase) are common, whereas the more severe hepatic complications are rare. In men, steroid use depresses levels of luteinizing hormone and follicle-stimulating hormones, which leads to decreased endogenous testosterone production, decre ...
... aminotransferase, alanine aminotransferase, and lactate dehydrogenase) are common, whereas the more severe hepatic complications are rare. In men, steroid use depresses levels of luteinizing hormone and follicle-stimulating hormones, which leads to decreased endogenous testosterone production, decre ...
Arrhythmia/Electrophysiology
... Background—Inhibition of cardiac sympathetic tone represents an important strategy for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic heart failure. Activation of presynaptic ␣2adrenoceptors is the most widely accepted mechanism of action of the antisy ...
... Background—Inhibition of cardiac sympathetic tone represents an important strategy for treatment of cardiovascular disease, including arrhythmia, coronary heart disease, and chronic heart failure. Activation of presynaptic ␣2adrenoceptors is the most widely accepted mechanism of action of the antisy ...
Elicited hippocampal theta rhythm: a screen for anxiolytic and
... unpublished). In line with these observations, enhanced hippocampal norepinephrine, but not 5-HT neurotransmission, induces theta (and gamma) oscillatory activity of the septohippocampal system in anaesthetized rats (Hajos et al., 2003a). The key point to note, in relation to the data that we will r ...
... unpublished). In line with these observations, enhanced hippocampal norepinephrine, but not 5-HT neurotransmission, induces theta (and gamma) oscillatory activity of the septohippocampal system in anaesthetized rats (Hajos et al., 2003a). The key point to note, in relation to the data that we will r ...
Personalized Medicine - Scientific and Commercial Aspects Brochure
... The aim of personalized medicine or individualized treatment is to match the right drug to the right patient and, in some cases, even to design the appropriate treatment for a patient according to his/her genotype. This report describes the latest concepts of development of personalized medicine bas ...
... The aim of personalized medicine or individualized treatment is to match the right drug to the right patient and, in some cases, even to design the appropriate treatment for a patient according to his/her genotype. This report describes the latest concepts of development of personalized medicine bas ...
Discovery and development of antiandrogens
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.