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Hardy Weinberg Equilibrium and Evolution SC.912.L.15.12 Microevolution • A key concept in understanding the evolution of populations is the gene pool • Gene pool: consists of all the alleles (alternative forms of genes) in all the individuals that make up a population – think of the gene pool as the reservoir from which the next generation draws its genes – the population's gene pool is where genetic variation—the raw material of evolution—is stored Microevolution • Microevolution: evolution on the smallest scalea generation to generation change in the frequencies of alleles within a population • Hardy Weinberg Equilibrium: populations that do not undergo change to their gene pools are not presently evolving – frequency of alleles in that gene pool are constant over time – useful because it provides a "no change" baseline that makes it possible to recognize when a gene pool is changing Hardy-Weinberg Principle • Necessary assumptions Allelic frequencies would remain constant if… – population size is very large – random mating – no mutation – no gene input from external sources – no selection occurring Hardy-Weinberg Principle • Calculate genotype frequencies with a binomial expansion (p+q)2 = p2 + 2pq + q2 • p2 = individuals homozygous for first allele • 2pq = individuals heterozygous for alleles • q2 = individuals homozygous for second allele