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Immunology Lecture 22 – Spring 2012 Effector T Cell Functions I. Overview A. Initial Interaction With Target Cells B. Formation of immunological synapse C. Cellular Polarization D. Effector functions are determined by effector molecules E. Secreted Cytokines F. Cell Surface Cytokines II. T Cell Mediated Cytotoxicity A. Overview B. Cytotoxic effector proteins III. Macrophage Activation by TH1 Cells A. Role of TH1 Cells in macrophage activation B. Features of Activated Macrophages C. Coordinated host response to intracellular bacteria