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GCSE Applied Science: Self-Assessment Checklist The Human Body and Health recall that some features are common to most cells (cell membrane, nucleus, cytoplasm). understand that respiration takes place in living cells and is a chemical reactions which uses glucose and oxygen to release energy and produce carbon dioxide and water as by products. recall the structure of the human circulatory system and the composition and functions of the blood including arteries, veins, capillaries, red blood cells, white blood cells, plasma, platelets. Part of the blood Plasma Red blood cell White blood cell platelets Its job Carry glucose & carbon dioxide around the body Carry oxygen around the body Protect us from diseases Helps the blood to clot understand that one loop of the circulatory system connects to the lungs to enable transfer of gases; the other loop connects to the rest of the body to supply cells with glucose and oxygen and remove carbon dioxide. know how humans maintain a constant body temperature. GCSE Applied Science: Self-Assessment Checklist label a simplified given diagram of the skin and understand the role of these structures in temperature regulation: dilation/constriction, sweating, erection of hairs; shivering as a means of generating heat. know that hormones are chemical messengers, produced by glands and carried by the blood. understand that glucose levels need to be fairly constant and that when the blood sugar level is too high, the pancreas releases the hormone insulin into the blood. This causes the liver to reduce the sugar level by converting sugar to insoluble glycogen and then store it. Diabetes is a condition in which a person’s blood glucose may rise to a fatally high level because the body does not produce enough insulin. understand that sense organs are groups of receptor cells which respond to a stimulus and relay this information to the brain. Some responses are reflex actions. These reactions are fast, automatic and some are protective. know that a reflex arc involves stimulus receptor coordinator effector. Label a given diagram of a reflex arc to show: receptor, sensory nerve cell, connecting nerve cell in spinal cord, motor nerve cell, effector, synapses. (Higher Tier only). know that the nucleus contains DNA. Analysis by ‘genetic fingerprinting’ can be used to show the similarity between two DNA samples, for instance in criminal and paternity cases. assess the issues surrounding ‘gene ownership’ as a result of DNA analysis. GCSE Applied Science: Self-Assessment Checklist know that DNA contains coded information that determines how cells function due to the types of proteins being coded for. Chromosomes are strands of DNA. know that DNA contains coded information that determines how cells function due to the types of proteins being coded for. Chromosomes are strands of DNA. understand meiosis as a nuclear division that halves the chromosome number during gamete formation and that the genetic composition of the daughter cells is not identical. (Stages in meiosis are not required.) (Higher Tier only) understand that genes are sections of DNA molecules that determine inherited characteristics and since body cells contain pairs of chromosomes, the genes which control particular characteristics also come as pairs. know that genes have different forms, called alleles. be able to complete Punnet squares and explain the outcomes of monohybrid crosses. For example, if both parents have gene pairs Bb know that new genes result from changes/mutations in existing genes and that mutations occur randomly. Mutations may be beneficial or harmful and may be passed on from parents to offspring. know that cystic fibrosis is an inherited disease which causes the production of thick mucus which blocks the bronchioles. Gene therapy has been tried but there are difficulties in targeting appropriate cells and there may be side effects. consider the scientific process of experimentation, observation and deduction which led Gregor Mendel to propose the mechanism of inheritance. Discuss why the significance of the work was not recognised and validated by scientists for many years. know that infectious diseases may be caused by micro-organisms and name some examples (measles, mumps, rubella, polio, tuberculosis (TB), foot and mouth, athlete's foot and skin infections.) understand that in human body cells one pair of chromosomes carries the genes that determine sex, XX (female) or XY (male), which separate and combine randomly at fertilisation. GCSE Applied Science: Self-Assessment Checklist give examples of a range of methods of protecting against infection by harmful micro-organisms e.g. in food production (personal hygiene, sterilisation, disinfectants, antiseptics) understand about the use of immunisation to protect humans and other animals from infection by specific micro-organisms (MMR, TB, foot and mouth, polio) know that antibiotics may kill some bacteria, but not viruses and understand that resistant bacteria such as MRSA can result from the over-use of antibiotics. discuss the ethical issues of using animals for testing drugs. understand that some conditions are due to lifestyle choices and explore information/data regarding the effects that alcohol, nicotine and drug abuse have on the chemical processes in peoples' bodies.