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ExternalElectiveChoicesforBiochemistryMajors TherearecoursesinotherA&SUGprograms,andintheBiomedicalSciencesGraduateProgram withintheSchoolofMedicine,thatcanbeusedasupperlevelelectivesfortheBiochemistry degree.YoucanuseONEoftheseoutside-of-the-Biochemistry-departmentcoursesasan upper-levelelectivetomeettherequirementsfortheprogram. Pleasekeepinmindthatnotallofthesecoursesareofferedeveryyear;someareofferedin alternateyears,andsomeareofferedonlywhentheinstructorhassufficientenrollment.Also, yourenrollmentintoanyofthesecourseswillbeatthediscretionofthecourse instructor.He/shemayhavetooverridepre-requisitecoursesandcapacities,andonlythe instructorofrecordcanmakethisdetermination. ExternalUndergraduateElectiveChoices Biol410EcologyandEvolutionaryGenomics-Thiscoursefocusesonmethods,both experimentalandcomputational,tostudythestructureofgenomesandtoanalyzegene expressionandproteinfunctiononagenome-widescale.Computationaltopicsincludegraphic approachesinsequenceassembly;discriminantanalysisingenefinding;dynamicprogramming insequencecomparison;andclusteringtechniquesintheanalysisofgeneexpressiondata. Biol412DevelopmentalBiology-Comparativebiologyofanimaldevelopmentemphasizing regulatorymechanisms. Biol461LHistology-Microscopicstructureofvertebratetissues,emphasizingcorrelationof structureandfunction. Biol425MolecularGenetics-Molecularbiologyofthegene. Biol428HumanHeredity-Geneticprinciplesappliedtohumans. Biol429MolecularCellBiology-Cellularprocesseswithemphasisonmembranes;includes readingoriginallandmarkpapersincellbiology. Biol437EvolutionaryGenetics-Mutation,naturalselection,geneticdrift;howevolutionary forcesshapepopulationstructure.Mechanismsofspeciation.Macroevolutionofbiochemical processesessentialtohigherorganisms,suchassignaltransductionpathways,developmental genesandcomplexorgans. Biol444GenomicsandGenomicAnalyses-OverviewofgenomicanalysesfromDNAsequence togeneexpressionandproteomics. Biol445BiologyofToxins-Principlesoftoxicology;pharmacologyandbiotransformationof xenobiotics.Mechanismofaction,medicaluses,andevolutionaryecologyofbiologicaltoxins. Biol446LaboratoryMethodsinMolecularBiology-PrinciplesofDNAandRNApurification, enzymaticmanipulationofnucleicacids,molecularcloning,gelelectrophoresis,hybridization proceduresandnucleotidesequencing. Biol450GeneralVirology-Structure,properties,andmolecularbiologyofviruses;virus-host interactions,multiplication,pathology,epidemiology,effectsofchemicalandphysicalagents, classification. Biol451MicrobialEcology-Roleofmicroorganismsinterrestrialandaquaticecosystems. Emphasisonbiogeochemistryandnutrientcycling. Biol452AnthropologicalGenetics(HumanGenetics)-Thiscourseexaminestheory,dataand methodsusedbygeneticanthropologiststoaddressquestionsabouthumanoriginsand prehistory,race,naturalselection,disease,andthesocialandscientificimplicationsofresearch ingeneticanthropology. Biol456Immunology-Immunoglobulinstructure,anitigen-antibodyreactions,immunityand hypersensitivity;experimentalapproachwillbeemphasized. Biol460MicrobialPhysiology-Physiologicalandbiochemicalactivitiesofbacteriaandfungi withemphasisoncellenergetics. Biol482LParasitology-Theprotozoaandwormsimportantinhumanandveterinarymedicine. Emphasisonlifehistories,epidemiologyandecologyofparasiteswithlaboratorypracticein identificationandexperimentation. Biol490BiologyofInfectiousOrganisms-Thefullspectrumofinfectiousentitiesincluding prions,virusesandparasiticprokaryotesandeukaryoteswillbediscussedwithrespecttotheir transmissibility,interactionswithimmunesystemsandtheirinfluencesonevolutionary processesandbiodiversityissues. Biol497PrinciplesofGeneExpression-Adetailedandcriticalstudyofhowdifferentgenesare regulatedduringthelifeofanorganism,principallyattheleveloftranscription. Chem422MolecularBiologyoftheGene-Focusesonthebiologicalchemistryofgene structure,expressionandregulationandthestructureandfunctionofthecellnucleus. Chem425OrganicChemistryofBiologicalPathways-Coversbasicprinciplesofmechanisms, acidity,stereochemistry;structures;propertiesofbiomolecules;reactionsinlipid, carbohydrate,aminoacid,nucleotidemetabolicpathways. Chem457EnvironmentalChemistry-Introductiontothechemistryofnaturalandpolluted environments,includingbothatmosphericandaquaticsystems. ExternalGraduateElectiveChoices Ifyouchoosetoenrollinoneofthefollowingcoursesatthe500-levelcourse,additional requirementsmustbemet.Coursesnumberedabove500arenormallyopenonlytograduate students;however,seniorstudentswithGPAsof3.0orhighermayreceiveundergraduate creditinthesecourses.Theymustobtainapprovalinadvancefromtheinstructorconcerned, thechairofthedepartment,andthedeanoftheirundergraduatecollege.Undergraduatesmay notenrollingraduate“Problems”coursesforundergraduatecredit. Biomed509PrinciplesofNeurobiology-Thiscoursecoverscellularstructureofneuronsand glia,theelectricalpropertiesofneurons,intercellularcommunication,andtheformation, maintenanceandplasticityofchemicalsynapses. Biomed510Physiology-Courseinregulatoryandsystemsbiology,andcardiovascularand pulmonarybiology. Biomed515CancerBiology-Fundamentalelementsofcancerdevelopmentandprogression willbethefocusofthiscourse.Basicbiochemicalandgeneticmechanismsoftumorigenesis, includinggenomicinstability,principlesoftumorcellinvasionandgrowthdysregulationwillbe emphasized. Biomed516MolecularGeneticsandGenomics-Coversgeneticandgenomicapproachesin modelorganisms(prokaryotes,fungi,worms,mouseandfruitflies)andhumanstostudy biologicalprocessesatthemolecular,cellular,tissue,organism,populationandevolutionary levels.Providesanintroductiontobioinformaticandcomputationalmethodsusedinsuch studies. Biomed522ExperimentalDesignandMethodsinMolecularandCellularBiosciences-This case-basedcourseisintendedforfirstyeargraduatestudentsandfocusesonpracticalissuesof howtodesign,planandconductscientificstudiesthroughappropriateuseofexperimental methodsanddataanalysis. Biomed532Neurochemistry-Anintroductiontoneurochemistryandneuropharmacology, withheavyemphasisonstudentparticipation,byreadingandevaluatingcurrentpublications. Pharm576CellularandMolecularPharmacology(1credit)WITHPharm580General Toxicology(2credits)–Mustbetakentogether. •PHRM576.IntroductoryPharmacology.Pharmacologyisabasicscienceconcerned withallaspectsoftheactionofdrugsonlivingsystems.Initsentirety,pharmacology embracesbiochemicalandphysiologicaleffects,mechanismsofaction, pharmacokinetics,andtherapeuticanddiagnosticusesofdrugs.Astrongworking knowledgeofpharmacologyisessentialtotheprofessionalroleofpharmacistsandto basicscientistsengagedindrugdiscoveryandunderstandinghowdrugswork.Thegoal ofthiscourseistogiveanoverviewoftheprinciplesofmodernmolecularandcellular pharmacology,aswellassomedetailsofdrugdelivery.Topicsinclude: biopharmaceuticalpropertiesofdrugs;receptortheory;absorption,distribution, metabolismandelimination;pharmacokineticsanddrugdelivery.Italsoservesasan IntroductorycoursetoPHRM580andPHRM598courses •PHRM580-GeneralToxicology.Toxicologyisanimportantbroad-baseddiscipline thatincorporatesinformationfrommanyareasbridgingthegapbetweenmolecular mechanismsoftoxinactivitytotheirimplicationsinreal-worldproblems.FortheSpring 2015semester,theGeneralToxicologycoursehasbeenrevampedtofocusonbasic scientificliteraturerelevanttotoxicologyandthescientificmethodthatareofinterest tograduatestudents.Scientificliteraturerelevanttotoxicologyandthescientific methodareemphasizedinalltopicscovered.Thegoalofthiscourseistogivestudents abroad,butcomprehensive,overviewoftheprinciplesoftoxicology.Topicswillbe taughtbyexpertsineachareaandwillincludeaspectsoftoxicologyonrelevanttoxic agents,molecularandcell-basedmechanismsofaction,aswellasdetailsoftargetorgan systemsandphysiologythatareaffectedbytoxins.