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Transcript
1
BIOL 404
TIME:
Immunology
MWF
W
INSTRUCTOR:
OFFICE:
PHONE:
E-MAIL
OFFICE HOURS:
Spring Term 2010
9:00 a.m. – 9:50 a.m. lectures in Chichester Science Center 222
2:00 p.m. – 3:40 p.m. laboratories in Chichester 222
Dr. David W. Buckalew
Room 305A
395-2586 (or 2586 from campus)
buckalewdw@longwood.edu
As posted or by appointment
M
1:00 – 3:00 p.m.
R
9:30 – 10:30 a.m.
Course description: This course focuses on the specific and non-specific immune responses
with particular emphasis on the human system. Relative to each category of immune response,
the interplay between immune signaling molecules and relevant cells, tissues, and organs are
discussed. Specific topics include: antigen recognition, processing, and presentation, T/B
lymphocyte maturation, activation, and differentiation, humoral immunity, cell-mediated
immunity, inflammation, hypersensitivity, acute and chronic disease responses, vaccines, and the
immunology of cancer.
Three lectures and one 2-hour lab period per week. 4 credits.
REQUIRED TEXTBOOKS:
Parham, Peter. 2009. The Immune System (3rd Ed.)
Garland Science, New York, NY. (Lecture)
COURSE OBJECTIVES:
 To gain an appreciation for the complexity and diversity of cellular and chemical
components at work to defend and rid the body of foreign cells and substances.
 To gain knowledge in the area of cell signal transduction and how it relates to
development, maturation, and responses of the variety of immune cells of the
body.
 To learn the distinctions between the innate and the adaptive immune responses,
where they occur, the organs, cells, and molecules involved, and an appreciation
for the collaboration that exists within and between these mechanisms of
immunity.
 To learn the distinctions between aspects of humoral and cell-mediated immunity
of the adaptive immune response and their many manifestations.
 To gain an appreciation for the diversity for the amount and div
 To become aware of the health affects that may occur when select component(s)
of these systems fail.
 To become aware of how problems relating to immunology are studied and
interpreted
 Analyze and interpret information acquired from primary literature sources, then
organize and communicate it in oral and written form.
 Demonstrate in writing and orally, a capacity for critical analysis of a specialized
or topical issue in immunology.
 Demonstrate the potential for life long learning, the ability to use information
technology, and effective time management skills
2
COURSE REQUIREMENTS:
THERE WILL BE NO "MAKE-UPS" FOR EXAMS, TESTS OR QUIZZES. ALL TESTS
WILL BE GIVEN AT THE TIME AND DATE SCHEDULED.
Course grading will be comprised of:
A) three tests given approximately every four (4) weeks
B) final examination (comprehensive) scheduled for Thursday, April 29 between
11:30 am – 2:00 pm in the lecture classroom
C) in-class quizzes
D) article reviews
E) laboratory component (incl. term paper and presentation)
Tardiness and Absences:
Class attendance and punctuality are strongly emphasized, as there is a high correlation
between course performance and attendance in this class. Attendance will be taken at the
beginning of class. Any student not present when roll is taken will be considered absent. If a
student arrives after roll is called, it is the responsibility of the student to personally inform the
instructor of his/her presence as soon as class is over. The instructor will adhere to Longwood’s
policy of applying an “F” grade for any student who misses more than 25% (11 absences) of the
class meetings (lecture and/or lab combined). An absent or tardy student will also be held
accountable for all materials missed during absence(s).
The instructor assumes all students taking Immunology are seriously interested in
attending graduate or professional school and desire to tailor their priorities pursuant to that goal.
COURSE EVALUATION:
The final grade will be determined as follows:
approx. %
three tests @ 100 pts. each
the final examination
ten quizzes @ 10 pts each
five article reviews @ 10 pts each
the laboratory component
total points possible
300 points (35%)
200 points (24%)
100 points (12%)
50 points (6%)
225 points (24%)
875 points (100%)
Grading Scale:
Points/Percentages and Final Grade
The instructor will adhere to a strict 60/70/80/90% scale in determining grades for this
course. All points are weighed equally from the lecture and lab quizzes, papers, and test scores.
Honor Code Policy:
I strongly support the Longwood University Honor System and expect you to do
likewise. All written work is to be pledged in full and signed. Any student found responsible
for an Honor Code violation in this course will receive an “F” grade.
3
COURSE OUTLINE AND SCHEDULE:
Some of the topics as well as the sequence of those topics are subject to change. Exams
may include more or less material than is listed in the schedule depending on how closely we
adhere to this outline........
Week of:
Topic:
Chapter
Jan 11
Overview/History of Immunologic understanding
Jan 18
Jan 25
Cells and Organs of the Immune/Lymphatic system
*******Article #1 due Friday 1/22
Innate Immune response and inflammation processes
Feb
1
******Article #2 due Friday 2/5
Principles of Adaptive Immunity
3
Feb
8
“
3
“
1
2
*************TEST ONE**********Friday, Feb 12 ********************
Feb 15
Immunoglobulins: Structure, diversity, and function
4
Feb 22
*****Article #3 due Friday 2/19
Immunity mediated by B cells and Antibodies
9
Mar 1
Antigen recognition by T cells
******Article #4 due Friday 3/5
Mar 8
Spring Break – no classes
Mar 15
T cell mediated Immunity
5
8
*************TEST TWO********Friday, Mar 19 ********************
Mar 22
Immune response to Infectious disease
10/11
Mar 29
Hypersensitivity
12
Apr
Autoimmune diseases
13
Vaccines
14
5
Apr 12
*************TEST THREE********Friday, April 16 **************
Apr 19
Wrap-up
Apr 23
Last day of classes
Apr 29
Final Exam (Thursday, April 29, 11:30 am – 2:00 pm)
*******Article #5 due Friday, 4/23