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Essay Contest Reveals Misconceptions of High School Students in Genetics Content Supplementary Table 1. Examples of the Range of Patterns of Inheritance Coverage in State Standards Specific to Broad State Text From Standard Most Specific Knowledge Virginia Mendel’s laws of heredity are based on his mathematical analysis of observations of patterns of inheritance of traits. The laws of probability govern simple genetic recombinations. Genotype describes the genetic make-up of an organism and phenotype describes the organism’s appearance based on its genes. Homozygous individuals have two identical alleles for a particular trait, while heterozygous individuals have contrasting alleles. When one allele masks the effect of another, that allele is called dominant and the other recessive. When an intermediate phenotype occurs and no allele dominates, incomplete dominance results. Skills Predict possible gametes in a dihybrid cross, given parental genotypes. Use a Punnett square to show all possible combinations of gametes and the likelihood that particular combinations will occur in monohybrid crosses. The sorting and recombination of genes in sexual reproduction results in a great variety of gene combinations in the offspring of any two parents. Inserting, deleting, or substituting DNA bases can alter genes. An altered gene may be passed on to every cell that develops from it, causing an altered phenotype. An altered phenotype may be beneficial or detrimental. Sometimes entire chromosomes can be added or deleted, resulting in a genetic disorder such as Trisomy 21 (Down syndrome). Skill Evaluate karyotype charts. Knowledge Forensic identification is an example of the application of DNA technology. There is great potential for the development of useful products through genetic engineering (e.g., human growth hormone, insulin, and pest- and disease-resistant fruits and vegetables). Eugenics, a pseudo-science of selective procreation, was a movement throughout the twentieth century, worldwide as well as in Virginia, that demonstrated a misuse of the principles of heredity. The Human Genome Project is a collaborative effort to map the entire gene sequence of organisms. This information will be useful in detection, prevention, and treatment of many genetic diseases. The potential for identifying and altering genomes raises practical and ethical questions. Cloning is the production of genetically identical cells and/or organisms. Virginia high school biology standards are available at: http://www.pen.k12.va.us/VDOE/Instruction/Science/ScienceCF-BIO.pdf Specific Missouri “The pattern of inheritance for many traits can be predicted by using the principles of Mendelian genetics. Scope and Sequence – Genetics and Heredity a. Explain how genotypes (heterozygous and homozygous) contribute to phenotypic variation within a species b. Predict the probability of the occurrence of specific traits, including sex-linked traits, in an offspring by using a monohybrid cross c. Explain how sex-linked traits may or may not result in the expression of a genetic disorder (e.g., hemophilia, muscular dystrophy, color blindness) depending on gender” Missouri high school biology standards are available at: http://www.dese.mo.gov/divimprove/curriculum/webframeworks/05SC.PDF Broad Arizona “Understand the molecular basis of heredity and resulting genetic diversity. PO1. Analyze the relationships among nucleic acids (DNA, RNA), genes, and chromosomes. PO2. Describe the molecular basis of heredity, in viruses and living things, including DNA replication and protein synthesis. PO3. Explain how genotypic variation occurs and results in phenotypic diversity. PO4. Describe how meiosis and fertilization maintain genetic variation.” Arizona high school biology standards are available at: http://www.ade.state.az.us/standards/science/downloads/strand4.pdf Most Broad Wisconsin “Explain current scientific ideas and information about the molecular and genetic basis of heredity” (2005). Wisconsin high school biology standards are available at: http://dpi.state.wi.us/standards/sciintro.html