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The assertion that the proposal contains three serious flaws is flawed. As stated within the Course Content portion of the Category II Proposal: “reading assignments will be based upon the Textbook of Veterinary Physiological Chemistry, 2nd Edition by L. R. Engelking (2011). This 596-page paperback text is subdivided into seven sections that collectively contain 94 chapters. Therefore, lectures will be apportioned according to the number of chapters within a section (see proposed class schedule below). Lectures will be used to integrate information from reading assignments with supplemental information obtained from three principal sources: (1) General Histology of the Mammal: An Atlas for Students of Medicine and Biology by R. V. Krstić (1985), (2) Hepatic Circulation by W. W. Lautt (2010), and (3) The Liver: Biology and Pathobiology, 5th Edition by I. M. Arias et al. (2009). In summary, course content will be based upon subject matter provided by a text along with the interpretation of this subject matter within a living context.” Therefore, the proposed course is not a reiteration of BB 350. A condensed list of chapter titles from Textbook of Veterinary Medicine is found in the table below. Please note that these chapter titles are shown in relation to BB 350 lecture topics as well as chapter titles from a contemporary biochemistry text used for undergraduate instruction. Next, students cannot, at present, enroll in a course entitled “Physiological Chemistry” at Oregon State University. This is what was meant by “physiological chemistry is a subject that is not taught at OSU.” This statement was made within the context of a course proposal as opposed to a summary of subject matter found within and among courses taught at OSU. The reader need only look at chapter titles from Biochemistry and Textbook of Veterinary Physiological Chemistry to see that each text differs in scope – even if they do share common ground. Amino acids, after all, are amino acids. They have a finite set of properties, and they are used by living organisms for certain purposes. That said, the appearance of false neurotransmitters within the central nervous system due to an imbalanced ratio between circulating branched chain and aromatic amino acids (due to liver malfunction) is the purview of physiological chemistry. To argue that physiological chemistry is merely a synonym for biochemistry is akin to Dr. Sheldon Cooper arguing that universities only need teach mathematics and physics because mathematics is the language of physics and physics explains the totality of the universe. Once again, the proposed course is not just another “biochemistry” course. In questioning the value of the proposed course to veterinary science students, the reviewer entirely missed the point of the table from Textbook of Medical Physiology (2006) found within the proposal’s rationale. Veterinarians seldom make decisions based upon X-ray crystallography, enzyme kinetics, or mass spectrometry. Rather, they make diagnoses from limited information, which oftentimes includes one or more attributes of an animal’s bloodstream. One’s ability to use limited information to make correct inferences is a valuable skill. Most people, including those who have taken a biochemistry course, have no clue as to why metabolic acidosis induces hyperkalemia and then why hyperkalemia induces cardiac arrhythmia. In summary, the proposed course will not duplicate any biochemistry course taught at OSU due to differences in scope and application. The table below serves as a comparison / contrast for: (1) lecture topics in BB 350 Elementary Biochemistry from Spring Term 2012, (2) chapter titles from a contemporary biochemistry textbook for sale at the OSU Bookstore (Biochemistry, 7th Edition, by Berg et al., 2012), and (3) a condensed list of chapters from Textbook of Veterinary Physiological Chemistry by Engelking (2011). BB 350 Lecture Topics Introduction Water/Biochemistry Amino Acids/Peptides Proteins (3D) Protein Purification Protein Purification/Enzymes Enzymes Enzyme Controls Membranes Nucleic Acids DNA Synthesis RNA Synthesis Protein Synthesis Biotechnology Viruses, Cancer, and Immunology Energy and Metabolism Carbohydrates Glycolysis Carbohydrate Storage Citric Acid Cycle Electron Transport & Oxidative Phosphorylation Lipid Metabolism Photosynthesis Nitrogen Metabolism th Biochemistry, 7 Edition Biochemistry: An Evolving Science Protein Composition & Structure Exploring Proteins & Proteomes DNA, RNA, and Information Flow Exploring Genes & Genomes Exploring Evolution & Bioinformatics Enzymes: Basic Concepts & Kinetics Catalytic Strategies Regulatory Strategies Carbohydrates Lipids and Cell Membranes Membrane Channels & Pumps Signal-Transduction Pathways Metabolism: Basic Concepts & Design Glycolysis & Gluconeogenesis The Citric Acid Cycle Oxidative Phosphorylation The Light Reactions of Photosynthesis The Calvin Cycle & Pentose Phosphate Pathway Glycogen Metabolism Fatty Acid Metabolism Protein Turnover & Amino Acid Catabolism Biosynthesis of Amino Acids Nucleotide Biosynthesis Biosynthesis of Membrane Lipids & Steroids DNA Replication, Repair, & Recombination RNS Synthesis & Processing Protein Synthesis Control of Gene Expression in Prokaryotes Control of Gene Expression in Eukaryotes Sensory Systems The Immune System Molecular Motors Drug Development Textbook of Veterinary Physiological Chemistry Chemical Composition of Living Cells Properties of Amino Acids Amino Acid Modifications Protein Structure Properties of Enzymes Enzyme Kinetics Protein Digestion Amino Acid Catabolism Transamination & Deamination The Urea Cycle Glutamine & Ammonia Nonprotein derivatives of amino acids Nucleotides Pyrimidine Biosynthesis Purine Biosynthesis Folic Acid Nuclei Acid & Nucleotide Turnover Carbohydrate Structure Polysaccharides and Carbohydrate Derivatives Glycoproteins & Glycolipids Overview of Carbohydrate Metabolism Glucose Trapping Glycogen Glycolysis Metabolic Fates of Pyruvate Hexose Monophosphate Shunt Uronic Acid Pathway Erythrocytes & Oxygen Toxicity Erythrocyte Metabolism Heme Biosynthesis & Degradation The Tricarboxylic Acid Cycle Leaks in the TCA Cycle Oxidative Phosphorylation Gluconeogenesis Carbohydrate Digestion Vitamin C Thiamin & Riboflavin Niacin & Pantothenic Acid Biotin & Pyridoxine Cobalamin Vitamins A, D, E, & K Iron Zinc Copper Manganese & Selenium Textbook of Veterinary Physiological Chemistry (cont.) Iodine & Cobalt Overview of Lipid Metabolism Fatty Acids Fatty Acid Oxidation Fatty Acid Biosynthesis Triglycerides & Glycerophospholipids Phospholipid Degradation Sphingolipids Lipid Digestion Cholesterol Bile Acids Lipoprotein Complexes Chylomicrons VLDL, IDL, LDL LDL Receptors and HDL Hyperlipidemias Eicosanoids Lipolysis Ketone Body Formation & Utilization Fatty Liver Syndrome Starvation: Transition into the PostAbsorptive Stage Starvation: The Early Phase Starvation: The Late Phase Exercise: Circulatory Adjustments & Creatine Exercise: O2 Consumption & Respiratory Quotient Exercise: Substrate Utilization & Endocrine Parameters Exercise: Muscle Fiber Types Exercise: Athletic Animals pH & Buffer Systems The Anion Gap Metabolic Acidosis Diabetes Mellitus (Metabolic Acidosis & Potassium Balance) Metabolic Alkalosis Respiratory Acidosis Respiratory Alkalosis The Strong Ion Difference Alkalinizing & Acidifying Solutions Dehydration / Overhydration