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` Cellular Respiration 8.1 Overview ` ` ` ` ` ` ` ` ` ` What is respiration? Three definitions ` ` ` Inspiration‐expiration Exchange of O2 for CO2 in lungs Consumption of O2 and production of CO2 in tissues ` ` ` ` Involves glucose Exergonic Produces ATP Redox reaction What are NAD+ and FAD? Enzymes use these during oxidation respiration FAD sometimes used instead What are the phases of respiration? Glycolysis Krebs cycle (citric acid cycle) Electron transport chain Cellular Respiration 8.2 Glycolysis ` ` ` ` ` What is glycolysis? Literally means _________ Happens outside mitochondrion Goal is to generate pyruvate Two stages ` ` ` ` Energy investment ` Phosphoryation using 2 ATP Energy harvest ` See next slide… What happens during energy harvest? Substrate level phosphorylization ` To make ATP ` ` ` Pyruvate also formed Overall reaction: Cellular Respiration 8.3 Krebs Cycle ` ` ` ` ` What is the Krebs Cycle? AKA the citric acid cycle Happens in mitochondrial matrix Goal: generate ATP, FADH2 and NADH from pyruvate Series of redox reactions ` A type of metabolic pathway ` ` ` ` ` ` What are the steps? Prepatory step ` Convert pyruvate to acetyle co‐A What happens next? Citric Acid Cycle ` Key: it’s a cycle– it repeats! What are the products of the Krebs cycle? Cellular Respiration 8.4 Electron transport chain ` ` ` ` What is the electron transport chain (ETC)? Series of redox reactions to make ______ Happens in cristae Oxidative phophorylation ` ` Consumes oxygen Produces ATP + H2O ` ` ` What are the steps of the ETC? Chemiosmosis involved Passing of ` ` Electrons H+ ` ` What is energy yield of oxidative respiration? After all three stages ` Cellular Respiration 8.5 Fermentation ` ` ` ` What happens if no oxygen is present? Anaerobic respiration ` ` Inorganic molecule is final electron acceptor Some bacteria use Fermentation ` Organic molecule is final electron acceptor Different types ` ` Alcoholic fermentation Lactic acid fermentation ` ` ` What happens in fermentation? Glycolysis Then ` ` pyruvate reduction NAD regeneration ` ` ` ` ` ` ` What are the pros and cons of fermentation? Pros ` Oxygen not necessary Cons ` Very low ATP production What is the metabolic pool? Compounds oxidized for entry into biosynthesis reactions Catabolism ` Deamination (in liver) Anabol