Download Zeng W, Al-Yamani E, JS Acierno, P. Ozand, JF Gusella

EIMAN AL-YAMANI
P.O. BOX 3221
Makkah, KSA
Tel. Home: 025365972
Te, work: 026240000 Ext. 22738
Mobile:
+966-555098946
E-Mail:
[email protected]
EDUCATION
Institution and Location
Degree.
Field of Study
Ambassador University Corporation
New York, NY, USA
MSc. (online)
Umm Al-Qura University
BSc.
2007
1995
Genetic Engineering
Biology (GPA 3.462)
EMPLOYMENT
Molecular Technologist II Molecular Biology Unit,
National Guard Hospital, Jeddah, KSA
2005- Present
Research Assistant, Department of Genetics, KFSHRC, Riyadh, KSA
2000-2005
Research Fellow, Molecular Neurogenetics Unit
Massachusetts General Hospital, Boston, MA. USA
1998- 2000
Research Technician, Molecular Genetics and Diagnosis Laboratory
King Faisal Specialist Hospital &
Research Center (KFSHRC), Riyadh, KSA
1996-1998
AWARDS
2 year scholarship from King Faisal Specialist Hospital & Research Center to train in Molecular
Neurogenetics at Massachusetts General Hospital, Boston, MA. USA
RESEARCH & CLINICAL WORK EXPERIENCE
National Guard Health Affair & King Khalid Guard Hospital – Jeddah
A- Establishing A New molecular pathology Unit
Oct – Dec 2006
B- Molecular Biology Unit
Sept 2005 – Aug 2006
1-Routine diagnostic essays for Infectious diseases including Qualitative and or Quantitative
tests for CMV, HBV, HCV, HIV, and HSV.
2- Family screen for Herpes including CMV, EBV, HSV, VZV, and HHV6.
3- Mycobacteria, species ID, molecular & Mycobacterium Tuberculosis- ID
4- Factor V Leiden
King Faisal Specialist Hospital & Research Centre - Riyadh (1996-1998)
Routine diagnostic assays :
1- Cystic Fibrosis: A descriptive study was undertaken to characterize the cystic fibrosis
transmembrane regulator gene mutations (CFTR) in the Saudi Arabian cystic fibrosis (CF)
population in relation to clinical presentation and demographic and ethnic origin. 70 patients
from 46 families were diagnosed as having CF, based on a typical clinical picture and sweat
chloride levels > 60 mmol/l and were screened for CFTR mutations. Twelve mutations were
identified in 34 families. The clinical picture did not differ significantly between patients of
different ethnic origins with the same CFTR mutation.
2- Factor V Leiden: A total of 148 patients were studied and none exhibited Factor V
mutations and only 30 patients had documented thromboembolic complications.
3- Mutations Analysis of MCAD by Heterdublex Analysis (MDE gel).
4-Mutation screening for Multi-sulphatase deficiency: We identified 4- Novel Polymorphism
by Sequencing using DNA samples from 72 Saudi patients.
4- Mutation analysis of SUOX gene in Saudi Patients with Sulfite Oxidase Deficiency: DNA
samples from 20 patients were screened for mutations in the SUOX gene. Amplification and
sequencing of the exons 1, 2 and 3 of the SUOX gene using PCR and cycle sequencing.
Novel mutations were found in 3 of the patients. Identification of these new mutations should
facilitate pre-implanation genetic diagnosis and selection of unaffected embryos for
pregnancy counseling in families with these mutations.
MASSECHUSETTS GENERAL HOSPITAL (1998- 2000)
1- Mapping of Biotin-responsive Basal Ganglia Disease in Saudi Patients
Linkage analysis was carried out on six Saudi Arabian Families with Biotin-responsive Basal
Ganglia Disease (BBGD). Using 302 genetic markers, BBGD was mapped to chromosome
2q36.3 and the disease has since been attributed to mutations in the SLC19A3 gene.
2- Identification of Novel mutations in Parkinson's disease Gene
Novel mutation was identified by screening 99 DNA samples of Venezuelan families for the
novel mutation by PCR and cycle sequencing.
3- Methcrolonyel-CoA: I mapped this disorder for two Saudi patients to chromosome 3 by using
Human chromosome mapping panels.
CONFERENCES & MEETINGS ATTENDED
The 3RD International Breast Cancer Conference
At Intercontinental Hotel – Jeddah
2011
7th Applied Medical Sciences Students Meeting
Held at king Abdulaziz University Conference Center, KAU, Jeddah
2011
Human Genetics Lecture
At King Abdulaziz Medical City, Jeddah
2010
VIII Saudi Scientific Hematology Society Congress
At The Crowne Plaza Hotel, Jeddah, KSA
2009
The 7th International Scientific conference of HH Princess
Al-Jawhara center for Genetic Diagnostics and Research at
Arabian Gulf University, Bahrain
2009
Update in Oncologic & Molecular Pathology, Jeddah, KSA
2006
Quality @ Health Symposium
2006
2nd Molecular Diagnostic Group Meeting, Jeddah, KSA
2005
Fundamentals of Conducting Research Symposium, KFSHRC, Riyadh
2004
Recent Advances in Reproductive Medicine , KFSHRC, Riyadh
2004
Neonatal Screening in the Kingdom of Saudi Arabia , KFSHRC, Riyadh
2004
Recent Advances in the Technology of IVF & Reproductive Medicine,
Dallah Hospital, Riyadh
2004
Cancer 2002 KFSHRC, Riyadh
2002
COURSES & WORKSHOPS ATTENDED
Certificate of Human Participants Protection Education for Research Teams
Online course, sponsored by The National Institutes of Health
2007
Antimicrobial Review Course & Workshop, KFSHRC, Riyadh
2003
Bioinformatics Workshop Empowered By DNA Star, KFSHRC, Riyadh
2003
Neuro-Linguistics Program, KFSHRC, Riyadh
2003
Recent Advances in Clinical Genetics & Mitochondrial Disorders, KFSHRC
Riyadh
2003
Professional Writing Belt School, Oxford, UK
.
Certificate of Human Participants Protection Education for Research Teams
Online course, sponsored by The National Institutes of Health
2001
Human Genetics Course, Harvard Medical School, Boston, MA, USA
1999
Basic Radiation Protection for Research & Hospital Personnel Safety
Course Massachusetts General Hospital, Boston, MA.USA USA
1998
Human Genetics in Clinical Investigation, Clinical Research Program
Massachusetts General Hospital, Boston, MA. USA
1998
2nd Symposium on Computer & Information Technology in the Health
Field, KFSHRC, Riyadh
1998
Statistics Analysis, KFSHRC, Riyadh
1997
3rd Saudi School on Human molecular Genetics, College of Medicine,
King Saud University, Riyadh
1997
Scholarly Writing Workshop, KFSHRC, Riyadh
1997
2003
PUBLICATIONS IN PEER REVIEWED JOURNALS
Al-Yamani E, Zeng W-Q, J.S. Acierno , Jr., Susan Slaugenhaupt, Tammy Gillis, Marcy E.
MacDonald, Pinar T. Ozand, Ozand, James.F. Gusella. Biotin-Responsive Basal Ganglia
Disease Maps to 2q36.3 and is Due to Mutation in SLC19A31. Am J Hum Genet 77:16, 2005
Seidahmed MZ, Alyamani EA, M.S. Rashed, A.A. Saadallah, OB Abdelbasit, M.M. Shaheed,
A.Rasheed, F.A.Sabry. Total Truncation of the Molybdopterin/Dimerization Domains of SUOX
Protein in an Arab Family with Isolated Sulfite Oxidase Deficiency. Am J Med Genet
136(2):205-9, 2005.
Zeng W, Al-Yamani E, J.S. Acierno, P. Ozand, JF Gusella. Amputations in SLC19A3 encoding
a novel transporter cause biotin-responsive basal ganglia disease Am J Hum Genet 2001; 69: 195.
A Novel Mutations in SUOX Sudani Patients (submitted).
PRESENTATIONS & ABSTRACTS
Mapping and Linkage analysis of BBGD gene at University of Oxford, The Wellcome Trust
Center for Human Genetics, Oxford, UK. 1999
First GCC Genetics Conference Attended participated and presented a paper on The Molecular
Basis of Hyperekplexia in Saudi Arabia Families, Bahrain, 2003.
OTHER SKILLS
Fluent in Arabic, verbal and written
Fluent in English, verbal and written.
Proficient with Microsoft Word, Excel PowerPoint, Adobe Photoshop
Experienced with Cyrillic program for linkage analysis & genotyping
Skilled with Bioedit & DNA STAR Sequencing Programmes
Competent with BLAST searches
EXTRA-CURRICULAR ACTIVITIES
Active member of Um Al-Qura Charity Organization
REFERENCES
Dr James Gusella, Director
Molecular Neurogenetics unit
Massachusetts General Hospital
Building 149
13th street
Charlestown, MA 02129-2000
Tel: 617-726 5724
Fax 617-726 5735
E-mail: [email protected]
Dr Mohamed Sabry, Group Leader
Department of Medicine
Arabian Gulf University
Bahrain
Tel: 973-36361876
E-mail: [email protected]