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Transcript
MOLECULES OF LIFE & MUTATIONS CHARLES UNIVERSITY versity is proud to announce the visitation ED SCHWARZ, Professor of Pathophym the Biocenter of the Medical University Austria who will introduce here a novel c as well as lecture format. Medicine as well as Biology, from semester 3 kindly invited to attend this 4 days interactive ciplinary course, and will thereby receive 4 ME 0:00 – 12:00 ure I: Crucial importance of understanding proteins for iseases in general 4:00 – 16:00 ture II: Understanding oncogenesis by understanding s 0:00 – 12:00 e PC room for learning a molecular modelling software the PDB and OMIM data banks f disease cases to work out underlying molecular homework) ision on the date of case presentation 4 or 7 or 9 or 10 or 11 or 14, 10:00 – 12:00 students homework and discussion s ns fees. Limited number of students allowed. This lecture intends to give introductory information on the importance of understanding the normal as well as abnormal stucture (as resulting from gene mutations or from allosteric effectors) of proteins for health as well as for understanding diseases. Next day follows a hands-on course in a PC room where attendees will receive a detailed step-by-step description for performinig practical molecular modelling on the PC by using appropriate software. Using the X,Y, Z coordinates of atoms, as deposited in the Brookhaven Protein Data Bank, PDB, students can „create“ the 3D structure of crystallographically elaborated proteins, alone or in interaction with small or large ligands such as substrates, drugs or DNA or other proteins. Attendees will learn also how to use the OMIM (Online Inheritance in Men) Data Bank from where they can retrieve the published mutations and consequent diseases. Arginine Vasopressine precursor and Diabetes insipidus serve as an illustative and informative example. A practical PC course on molecular modelling and explaining genetic diseases November 24 – 25, 2015 by Prof. Siegfried Schwarz, Medical University Innsbruck, Austria and Ass.Prof. Jiri Hatina, Charles University in Prague, Medical Faculty in Pilsen, Czech Republic Dr. Karel Drbal, Charles University in Prague, Faculty of Science, Czech Republic After this course, students will get assigned an individual protein and disease that they will have to elaborate as homework just in the way they have learnt it in the course. They should prepare a short lecture in Power Point. On the last day, students will present their homework in front of all attending colleagues including the Professors. So, everybody learns from the others, kind of a multiplication effect. One of the powers of molecular modelling resides in its informative value in displaying molecules, in total or in portions thereof, in different formats such as wireframe, protein backbone, atoms, overall surface etc. It is possible to turn the molecule in all directions and to see in real time the various aspects of it. Thereby, various structural characteristics can be recognized, domains of certain structure or charge or hydrophobicity or shape or other properties, which can serve e.g. as ligand-binding domain, as DNA-binding domain or as drug-metabolizing pocket or as a domain for any other biological purpose. Most importantly, points of mutation, as documented in the OMIM and other data bases, can be „mapped“ into such a model in order to understand which function of the protein would thus be altered and whether this change in structure would be would be loss or gain or recessive or dominant. Sponsored by