Download PATHOPHYSIOLOGY LAB QUESTIONS Laboratory

PATHOPHYSIOLOGY LAB QUESTIONS
Laboratory evaluation of serum proteins and enzymes
4/1
Laboratory results of an adult male patient with fever are as follows:
serum total protein: 70 g/l, A/G quotient: 1, serum electrophoresis:
albumin 50% (↓), alpha­1 12% (↑), alpha­2 15% (↑), beta 10%, gamma
13%. 1­acidic glycoprotein, 1­antitrypsin, C­reactive protein and
haptoglobin are increased, transferrin is decreased.
The above alterations are characteristic of what type of reaction?
4/2
A female patient is admitted to the department of gynecology with
complaints of long­standing diffuse, lower abdominal pain. Laboratory
data: serum total protein 79 g/l, A/G quotient 0.81, serum
electrophoresis: albumin 45% (↓), 1: 7% (↑), : 14% (↑), : 10%,  
24% (↑), IgG: 18 g/l (↑). Acute phase proteins are close to normal.
The above alterations are characteristic of what type of reaction?
4/3
A 50­year­old male patient is admitted to the department of medicine.
He has massive edemas and proteinuria. BP: 130/70 mmHg, total
serum protein: 50 g/l. Albumin less than 30 g/l. ­macroglobin and
beta­globulins are increased, other protein fractions are lower than
normal. Serum cholesterol is high. What is the most likely diagnosis?
4/4
Evaluation of the plasma proteins of a 50­year­old male patient gives
the following results: total serum protein: 90 g/l, A/G quotient: 0.40,
albumin: 27%, gamma globulin: 55% with an intense, narrow­based
peak. Acute phase reactants are normal. Serum Ca++ and uric acid are
elevated. Erythrocyte sedimentation rate is increased. What is the
most likely diagnosis and what diagnostic procedure would you order?
4/5
In a patient with moderate unconjugated hyperbilirubinemia acute
phase reactants are normal, haptoglobin is decreased. Serum iron
concentration is high, total iron binding capacity (TIBC) is decreased,
total serum LDH activity is elevated. What is the most likely
diagnosis?
11/11/04
1/2
Protein
4/6
A patient seeks evaluation for rapid loss of body weight and malaise.
Laboratory findings: serum bilirubin 60 mol/l (mostly conjugated).
Total serum LDH and ALP activaties are elevated. Serum alpha­
fetoprotein (AFP) is markedly elevated. What is the most likely
diagnosis and what other diagnostic procedures would you order?
11/11/04
2/2
Protein