Download File - the Drug Card Database

Gulf Coast Community College - Associate Degree Nursing
NUR 1260C – Gerontological Nursing
Medication Cards
Student Name:
Jessica Haase
Name of Drug:
Trade Name:
Salsalate
Amigesic, Anaflex, Disalcid, Marthritic, Mono-Gesic, Salflex,
Salgesic, Salsitab
Classification:
Salicylates, nonopioid analgesic
Usual Adult Dose:
1g tid initially, further titration may be required
Patient’s Dose:
500mg tab qid for generalized pain
Action:
Produce analgesia and reduce inflammation and fever by inhibiting
the production of prostaglandins. Therapeutic effects include
analgesia, inflammation reduction, fever reduction.
Adverse Effects:
GI bleeding, dyspepsia, epigastric distress, nausea, exfoliative
dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis,
tinnitus, abdominal pain, anorexia, hepatotoxicity, vomiting,
allergic reactions including anaphylaxis and laryngeal edema.
Drug Interactions:
May ↑ activity of penicillins, phenytoin, methotrexate, valproic
acid, oral hypoglycemic agents, and sulfonamides. May ↓
beneficial effects of probenecid or sulfinpyrazone. Corticosteroids
may ↓ serum salicylate levels. Urinary acidification ↑ reabsorption
and may ↑ serum salicylate levels. Alkalinization of the urine or
the ingestion of large amounts of antacids ↑ excretion and ↓ serum
salicylate levels. May blunt the therapeutic response to diuretics,
and antihypertensives. ↑ risk of GI irritation w/NSAIDs. ↑
anticoagulant effect and bleeding risk when using aspirin w/arnica,
chamomile, clove, feverfew, garlic, ginger, ginkgo, Panax ginseng,
and others. Foods capable of acidifying the urine may ↑ serum
salcylate levels.
Nursing Implications:
Pts who have asthma, allergies, and nasal polyps or who are
allergic to tartrazine are at an ↑ risk for developing hypersensitivity
reactions. Assess pain and limitation of movement; note type,
location, an intensity before and at the peak after administration.
Lab Considerations: Monitor hepatic function before antirheumatic therapy and if
symptoms of hepatotoxicity occur; more likely in pts, especially
children, w/rheumatic fever, SLE, juvenile arthritis, or pre-existing
hepatic disease. May cause ↑ serum AST, ALT, and alkaline
phosphatase, especially when plasma concentrations exceed
25mg/100mL. May return to normal despite continued use or dose
reduction. If sever abnormalities or active liver disease occurs,
discontinue and use w/caution in future. Monitor serum salicylate
levels periodically w/prolonged high-dose therapy to determine
dose, safety, and efficacy, especially in children w/Kawasaki
disease.