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Gulf Coast Community College - Associate Degree Nursing NUR 1260C – Gerontological Nursing Medication Cards Student Name: Jessica Haase Name of Drug: Trade Name: Salsalate Amigesic, Anaflex, Disalcid, Marthritic, Mono-Gesic, Salflex, Salgesic, Salsitab Classification: Salicylates, nonopioid analgesic Usual Adult Dose: 1g tid initially, further titration may be required Patient’s Dose: 500mg tab qid for generalized pain Action: Produce analgesia and reduce inflammation and fever by inhibiting the production of prostaglandins. Therapeutic effects include analgesia, inflammation reduction, fever reduction. Adverse Effects: GI bleeding, dyspepsia, epigastric distress, nausea, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, tinnitus, abdominal pain, anorexia, hepatotoxicity, vomiting, allergic reactions including anaphylaxis and laryngeal edema. Drug Interactions: May ↑ activity of penicillins, phenytoin, methotrexate, valproic acid, oral hypoglycemic agents, and sulfonamides. May ↓ beneficial effects of probenecid or sulfinpyrazone. Corticosteroids may ↓ serum salicylate levels. Urinary acidification ↑ reabsorption and may ↑ serum salicylate levels. Alkalinization of the urine or the ingestion of large amounts of antacids ↑ excretion and ↓ serum salicylate levels. May blunt the therapeutic response to diuretics, and antihypertensives. ↑ risk of GI irritation w/NSAIDs. ↑ anticoagulant effect and bleeding risk when using aspirin w/arnica, chamomile, clove, feverfew, garlic, ginger, ginkgo, Panax ginseng, and others. Foods capable of acidifying the urine may ↑ serum salcylate levels. Nursing Implications: Pts who have asthma, allergies, and nasal polyps or who are allergic to tartrazine are at an ↑ risk for developing hypersensitivity reactions. Assess pain and limitation of movement; note type, location, an intensity before and at the peak after administration. Lab Considerations: Monitor hepatic function before antirheumatic therapy and if symptoms of hepatotoxicity occur; more likely in pts, especially children, w/rheumatic fever, SLE, juvenile arthritis, or pre-existing hepatic disease. May cause ↑ serum AST, ALT, and alkaline phosphatase, especially when plasma concentrations exceed 25mg/100mL. May return to normal despite continued use or dose reduction. If sever abnormalities or active liver disease occurs, discontinue and use w/caution in future. Monitor serum salicylate levels periodically w/prolonged high-dose therapy to determine dose, safety, and efficacy, especially in children w/Kawasaki disease.