* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Drug Name Valproate, Sodium Valproate
Prescription costs wikipedia , lookup
Pharmaceutical industry wikipedia , lookup
Drug discovery wikipedia , lookup
Drug design wikipedia , lookup
Plateau principle wikipedia , lookup
Pharmacogenomics wikipedia , lookup
Drug interaction wikipedia , lookup
Neuropharmacology wikipedia , lookup
List of comic book drugs wikipedia , lookup
Pharmacokinetics wikipedia , lookup
Dydrogesterone wikipedia , lookup
Drug Name Drug Use Dose (loading dose, maintenance dose) Therapeutic Range Toxic Range Bioavailability Volume of Distribution Normal Half Life Half Life in End Stage Renal Disease Elimination Route Average Time to Steady State Serum Sampling Times Sampling Interval Other Comments/Considerations Valproate, Sodium Valproate, Valproic Acid Anticonvulsant, Neuropathic pain, bipolar disorder, migraine Adult doses Epilepsy: initially 15mg/kg in divided doses increasing at twice weekly intervals by 200mg according to response. Maintenance dose rarely > 40mg/kg Bipolar Disorder: 500-2000mg daily Migraine Prophylaxis: 200-400mg bd Neuropathic Pain: 400-2000mg daily 280-700micromol/L (40-100mg/L) for epilepsy Above 300micromol/L is needed for effective treatment of acute mania >700micromol/L (>100mg/L) 90-100% 0.2L/kg 6-20hrs Unchanged; 20-30hrs in liver disease Hepatic (>90%) 1-5 days Measure trough level (pre dose level) 2-4 days after beginning treatment or 2-4 days after a change in dose or if displaying signs and symptoms of toxicity Poor correlation between therapeutic efficacy and plasma concentration but serum levels may be useful to confirm toxicity or compliance. Hepatic impairment may increase serum concentration. Potential for drug interactions