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SIBO Treatment Protocols Prescription and Herbal effects for Pregnancy, Lactation, Pediatrics List courtesy of Dr. Allison Siebecker, www.siboinfo.com Pregnancy Category B: Metronidazole, Erythromycin- Regular Dose Cat B: “Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.” Note: Prucalopride- European info is analogous to US Category B Safe for pregnancy: Allimed, Low Dose Naltrexone aka LDN, Iberogast (Otillinger), Ginger (up to 2,000mg- Thompson) Category C: Rifaximin, Neomycin Cat C: “Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.” Not recommended: Motil Pro (Label - “not to be taken by pregnant or lactating women”) Lactation Not Secreted in Milk: Rifaximin, Neomycin (clinically insignificant amount in milk), Low Dose Erythromycin Prucalopride: no anticipated effects, lack of human data OK: Allimed, Iberogast, Ginger. At 8 months- Berberine, Oregano. Secreted In Milk: Metronidazole Not Recommended: Motil Pro (Label - “not to be taken by pregnant or lactating women”) Pediatric Use Rifaximin: 10-30mg/kg x 7-14 days (30mg showed better results), or 200mg 3xday Neomycin: 250mg 2xd x14 days Metronidazole: 30 to 50 mg/kg/day orally in 3 divided doses, Maximum dose: 2.25 g/day (we haven’t used it) Allimed, Neem, Biocidin, Goldenseal – ½ adult dose (or ¼ if very young/low weight) Prucalopride: 0.01mg/kg, >50kg= adult dose of 0.5mg Low Dose Erythromycin: 25mg/night Iberogast: 1-30 drops/night Unknown: Motil Pro As seen in Diane Kazer’s Interview with Dr Alison Siebecker in The Sexy Belly Guide www.thesexybellyguide.com