* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download PATHOPHYSIOLOGY LAB QUESTIONS Laboratory
Survey
Document related concepts
Phosphorylation wikipedia , lookup
G protein–coupled receptor wikipedia , lookup
List of types of proteins wikipedia , lookup
Magnesium transporter wikipedia , lookup
Intrinsically disordered proteins wikipedia , lookup
Protein phosphorylation wikipedia , lookup
Protein folding wikipedia , lookup
Protein (nutrient) wikipedia , lookup
Protein structure prediction wikipedia , lookup
Protein moonlighting wikipedia , lookup
Nuclear magnetic resonance spectroscopy of proteins wikipedia , lookup
Transcript
PATHOPHYSIOLOGY LAB QUESTIONS Laboratory evaluation of serum proteins and enzymes 4/1 Laboratory results of an adult male patient with fever are as follows: serum total protein: 70 g/l, A/G quotient: 1, serum electrophoresis: albumin 50% (↓), alpha1 12% (↑), alpha2 15% (↑), beta 10%, gamma 13%. 1acidic glycoprotein, 1antitrypsin, Creactive protein and haptoglobin are increased, transferrin is decreased. The above alterations are characteristic of what type of reaction? 4/2 A female patient is admitted to the department of gynecology with complaints of longstanding diffuse, lower abdominal pain. Laboratory data: serum total protein 79 g/l, A/G quotient 0.81, serum electrophoresis: albumin 45% (↓), 1: 7% (↑), : 14% (↑), : 10%, 24% (↑), IgG: 18 g/l (↑). Acute phase proteins are close to normal. The above alterations are characteristic of what type of reaction? 4/3 A 50yearold male patient is admitted to the department of medicine. He has massive edemas and proteinuria. BP: 130/70 mmHg, total serum protein: 50 g/l. Albumin less than 30 g/l. macroglobin and betaglobulins are increased, other protein fractions are lower than normal. Serum cholesterol is high. What is the most likely diagnosis? 4/4 Evaluation of the plasma proteins of a 50yearold male patient gives the following results: total serum protein: 90 g/l, A/G quotient: 0.40, albumin: 27%, gamma globulin: 55% with an intense, narrowbased peak. Acute phase reactants are normal. Serum Ca++ and uric acid are elevated. Erythrocyte sedimentation rate is increased. What is the most likely diagnosis and what diagnostic procedure would you order? 4/5 In a patient with moderate unconjugated hyperbilirubinemia acute phase reactants are normal, haptoglobin is decreased. Serum iron concentration is high, total iron binding capacity (TIBC) is decreased, total serum LDH activity is elevated. What is the most likely diagnosis? 11/11/04 1/2 Protein 4/6 A patient seeks evaluation for rapid loss of body weight and malaise. Laboratory findings: serum bilirubin 60 mol/l (mostly conjugated). Total serum LDH and ALP activaties are elevated. Serum alpha fetoprotein (AFP) is markedly elevated. What is the most likely diagnosis and what other diagnostic procedures would you order? 11/11/04 2/2 Protein