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Transcript
Sinerik Ayrapetyan “Cell Hydration Variation is a Primary Mechanism for Intracellular Signaling System in Norm and Pathology” The hydration is one of the fundamental cell parameters which is determining the functional activity of cells by two pathways: a) “folding-unfolding” mechanisms of intracellular macromolecules, including DNA, and b) surface-dependent regulation of the number of functional active protein molecules (enzymes, receptors, ionic channels) in Protoplasmatic Membrane (PM). It is known that PM is highly permeable for water. Because of the existence of special water channels (aqua pores) in PM, the water transports through the membrane take place much faster than predicted by simple osmotic diffusion. The transient water fluxes through PM have strong modulation effects on membrane conductive function and changing intracellular collective water dynamics. Therefore, the factor induced changes in cell hydration was suggested as a primary signaling mechanism to switch on cell adaptive metabolic pathways, dysfunction of which leads to cell pathology, including aging. By our previous study it was shown that aging– induced depression of Ca efflux from the heart muscle and brain cells leads to decrease in sensitivity of tissues hydration to different environmental factors because of higher intracellular Ca-induced cytoplasma coagulation. It was suggested that age-dependent dysfunction of Na/K ATPase catalytic α3/ α2 isoform − dependent intracellular signaling system controlling cell hydration is responsible for age related medical disorders. The aim of the present research project is to study the functional role of Na/K ATPase catalytic α3/ α2 isoform in Norm and Pathology. Sinerik Ayrapetyan, Chairholder of UNESCO Chair-Life Sciences International Postgraduate Educational Center 31 Acharian St., Yerevan, 0040, Armenia Tel: +374 10 624170/612461 Fax: +374 10 624170 Email: [email protected] URL: http://www.biophys.am