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Chapter 7 Understanding Pain congenital insensitivity - a very rare genetic disorder that prevents one from experiencing any pain at all. While it may sound good, the consequences are very serious. somatosensory system - The part of the nervous system that carries sensory information from various parts of the body (e.g., from the skin and muscles) to the brain. afferent neurons - are also called sensory neurons. They relay information from the sense organs (e.g., touch) toward the brain. efferent neurons - are also called motor neurons. They carry neural impulses from the brain to the muscles. primary afferents - Are specialized sensory neurons in the skin and other places. They respond to physical energy (e.g., touch) and convert it to neural signals that travel to the spinal cord and brain. action potential - is the technical term for when a neuron "fires." In response to sufficient amounts of neurotransmitters, or physical stimulation (for the primary afferents), a signal travels down the neuron's axon and causes release of neurotransmitters. nocioception - is the process of perceiving pain. nociceptors - Sensory receptors in the skin and organs that are capable of responding to various types of stimulation that may cause tissue damage (heat, cold, cutting, or burning). myelin - A fatty substance that acts as insulation for the axons of some neurons. Neural impulses are transmitted much faster by neurons with myelinated axons. fiber size - larger fibers (of larger neurons) transmit messages faster than smaller fibers. A fiber is basically the same thing as an "axon." A beta fibers - are both large and myelinated. They transmit information "100 times faster" than C fibers. They rapidly transmit sensory information. A-delta fibers - are small sensory fibers that are involved in the experience of “fast” pain that is "sharp" or "pricking." C fibers - are smaller and unmyelinated. Their slower transmission results in sensations that are dull, aching, or lingering. About 60% of all sensory afferents are "C fibers." nerve - A group or bundle of fibers (axons) that travel together (like a large electrical cable made up of hundreds of wires). Some nerves (afferent and efferent) are referred to as "Tracts." the cranial Nerves - Sensory information from the head and neck area travel to the brain via "12 cranial nerves." Information from all other body areas travels to the brain via the spinal cord. spinal cord - carries afferent (sensory) information to the brain and efferent (motor) information from the brain to the muscles (see Figure). dorsal horns - The back part of the spinal cord (away from the stomach) that receives sensory input (via the sensory tracts). There, the sensory fibers connect to small "secondary afferents" which, in turn, connect to efferent (motor) fibers that leave the ventral (front) side of the spinal cord. The messages also travel up the spinal cord via other neurons to the brain. transmission cells - "secondary afferents" and "interneurons" are all different names for the same thing, cells that connect neurons to other neurons. laminae - Are different layers of the dorsal horns which are composed of cell bodies. substantia gelatinosa - Is made up of layers 1 and 2 of the dorsal horns and is important in modulating sensory input. thalamus - Structure in the forebrain that acts as a relay center for incoming sensory information and outgoing motor information (from and to the spinal cord). somatosensory cortex - The part of the brain that receives and processes sensory input from the body. primary somatosensory cortex - receives information from the thalamus that allows the entire surface of the skin to be mapped onto the somatosensory cortex. The more sensitive areas of the skin (face and lips) take up a much larger part of the cortex relative to less sensitive parts like the back (see Figure). emotional and physical pain - May be all the same to the brain. Eisenberg et. al. (2003) found that experimentally induced emotional pain (social rejection) had the same activating effect on certain brain areas as physical pain. endorphins - Along with the enkephalins and dynorphin are naturally occurring neurochemicals whose pain lowering effects resemble those of the opiates. glutamate and substance p - Are neurotransmitters that sensitize (or excite) the neurons that relay pain messages. periaqueductal gray - An area of the midbrain that, when stimulated, decreases pain. It sends signals, via the medula, to the substantia gelatinosa in the spine's dorsal horn. Endorphin release blocks pain transmission (see Figure) medulla - The structure of the hindbrain just above the spinal cord. Sensory and motor messages travel through it. how pain is viewed - Prior to about 1900, pain was thought to be directly proportional to the extent of tissue damage. C. A. Strong then proposed that the experience of pain reflected BOTH sensory information AND the person's interpretation of it. the IASP definition of pain - The international Association for the Study of Pain (IASP) defined pain as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." acute pain - Short-term pain that results from tissue damage or other trauma (e.g., burns, surgery, dental work, childbirth). chronic pain - Pain that endures beyond the time of normal time of healing, it is frequently experienced in the absence of detectable tissue damage. prechronic pain - Pain that endures beyond the acute phase but has not yet become chronic. This is the "most crucial stage of pain" because if the person does not overcome or adjust to the pain now, it may become chronic and be accompanied by feelings of hopelessness. chronic recurrent pain - Refers to alternating episodes of intense pain and no pain. the experience of pain - Henry Beecher (1946, 1956) suggested that "the intensity of suffering is largely determined by what the pain means to the patient." He observed that some wounded WW II soldiers didn't mind the pain that much because it removed them from the chance of further injury or death. conditioning - Both classical and operant, plays a role in pain. For many, the sound of the dentist's drill has been "classically conditioned" as a stimulus that predicts pain. Person's who receive sympathy and are released from work or other responsibilities because of their illness may develop chronic pain because their "pain" behaviors are being reinforced by "operant conditioning." the "pain resistant personality" - Does NOT exist according to our authors. They do suggest that there are "cultural differences" in how people respond to pain. anxiety, worry, and negative outlook - have been associated with heightened sensitivity to pain. Chronic pain sufferers do have higher levels of anxiety and depression BUT cause and effect is hard to determine. specificity theory of pain - An early theory suggesting that specific pain fibers and pathways exist. Thus, pain would be equal and proportional to the amount of tissue damage. The theory is now viewed as being "incorrect." gate control theory of pain - A theory of pain holding that structures in the spinal cord (e.g., the substantia gelatinosa) act as a gate for sensory input that is interpreted as pain. In general, A beta and C fibers open the gate (more pain). A delta fibers close the gate (less pain) (see Figure) central control trigger - Proposed by Melzack and Wall, "cognitive processes" such as beliefs and prior experiences trigger nerve impulses that descend from the brain and influences the perception of pain. measurement of pain - Researchers have developed three types of measurement: (1) self-report ratings, (2) behavioral assessments, and (3) physiological measures. visual analogue scale (VAS) - Is a self-report rating scale in which patients mark a point on a line (no pain at one end, worst possible pain at the other) and the line length from no pain to the marked point is measured. Research has showed the VAS as superior to word descriptors and numerical scales. McGill Pain Questionnaire - Consists of several sections and is currently the most widely used pain questionnaire. the "neurotic triad" - is a personality "profile" on the Minnesota Multiphasic Personality Inventory (MMPI) that has been consistently associated with reported pain (high hypochondriasis, depression, and hysteria scores). Electromyography (EMG) - Measures muscle tension and has been used to asses back, neck, and jaw pain. However, reports of pain and EMG levels are not consistent so it may NOT be a very good assessment of pain. syndrome - Is a set of symptoms that occur together and characterize a condition. Headaches are the most common pain syndrome. migraine headaches - Involve blood flow, originate in the brainstem, may be partially genetic in cause, have a rapid onset, and affect one side of the head. Some experience an "aura" (sensory disturbance) before onset. More common among women by two to three times. tension headaches - Are caused by sustained muscle contractions in the neck, shoulders, scalp, and face. Onset is gradual and both sides of the head are affected. cluster headaches - A type of severe headache that occurs in clusters (bunches) on a daily or near daily basis. These are much more common in men than in women (10 to 1). rheumatoid arthritis - An autoimmune disorder with severe pain characterized by loss of cartilage, bone, and tendons, within or around joints. osteoarthritis - Is the most common form of arthritis. It involves progressive inflammation of the joints, made worse by movement. It is mostly confined to older people. phantom limb pain - The experience of chronic pain in an absent body part. To the brain, the body part is still there. back braces? - For support have become common for those whose jobs require a lot of lifting and moving. According to our text, these devices have NO effect in preventing injuries.