Download BIO 219 Spring 2013 Outline for “Cell Metabolism” Energy (ATP

BIO 219
Spring 2013
Outline for “Cell Metabolism”
Energy (ATP)
Where do we get it?
Why do we need it?
Types of cell metabolism
Anaerobic vs. Aerobic respiration
Glucose metabolism
4 steps of cellular respiration (aerobic)
Glycolysis (cytoplasm)
Energy investment phase & energy-yielding phase
Net yield
Pyruvate metabolism (mitochondria)
Pyruvic acid → Acetyl CoA
Oxygen (Why do we need it?)
Net yield
Citric Acid Cycle (mitochondria)
Eight-step process
Oxygen (Why do we need it?)
Net yield
Electron Transport Chain (mitochondria)
Five integral membrane proteins
NADH & FADH2
Oxygen (Why do we need it?)
Net yield
Fermentation
Glycolysis
Lactic acid production
What about fats and proteins as an energy source?
Objectives: By the end of lecture today you should be able to . . .
(1) Describe the similarities and differences between aerobic and anaerobic
metabolism.
(2) What does ATP stand for? Describe its general structure.
(3) What are the four steps of aerobic cellular respiration? What happens in each
step? What is the starting molecule in each step? Where in the cell does each
step occur? What is the net yield of products for each of these pathways?
(4) What is the role of NADH and FADH2 in ATP production? What do NADH and
FADH2 stand for? In other words, be able to write out the proper scientific names
for these molecules.
(5) How does ATP synthase make ATP? In which “step” of cellular respiration does
the synthase operate?
(6) What is the role of oxygen in cellular respiration?
(7) When is anaerobic fermentation used to make ATP? What is the end product of
fermentation? Is fermentation as efficient as cellular respiration in making ATP?
(8) How can fat and protein catabolism contribute to ATP production? Assuming
oxygen is present, what biochemical pathway(s) would the protein or lipid
metabolites utilize?