Download 21 356 Molecular Biology Spring 2017

CourseSyllabusSpring2017
120:356MolecularBiology
INSTRUCTORS:
Susan Seipel
EMAIL:
[email protected]
OFFICE/OFFICE
HOURS:
Boyden 312; W,F 1:00 PM – 2: 00 PM, or by
appointment
COURSE
WEBSITE:
Blackboard
COURSELOCATION(S): Boyden 413
MEETINGTIME(S):W,F 11:30 AM – 12:50 PM
COURSEDESCRIPTION:
This course covers topics focused on gene expression and its regulation in eukaryotic cells. Specific
areas of focus include: Gene organization and chromosome structure, Mechanisms of replication,
Mutations, Mechanisms of DNA damage and repair, Transcription and regulation of RNA synthesis, Posttranscriptional processes and regulation, Translation and post-translational modifications, Nucleic acid
biotechnology, Structure and roles of noncoding RNA, and Genomics and databases.
PREREQUISITES:
21:120:201, 21:120:202, 21:120:205, and 21:120:206 OR 21:120:101, 21:120:102, 21:120:201, and 21:120:202
REQUIRED TEXT:
David P. Clark and Nanette J. Pazdernik(2013) Molecular Biology:Second Edition, AP Cell Press ISBN: 9870-12-378594-7
LEARNING OBJECTIVES/GOALS:
Upon successful completion of this course, participants will be able to:
1. Describe how the structure of DNA, RNA, Proteins, Lipids, and Carbohydrates contributes to their
specific functions.
2. Describe the central dogma of the flow of genetic information.
3. Describe the intermolecular forces used to regulate interactions between DNA, RNA, Proteins, Lipids,
and Carbohydrates.
4. Discuss the roles of non-coding RNAs in regulating gene expression and cellular function
5. Describe how DNA, RNA, and Proteins are synthesized, regulated, and degraded in cells
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Course Syllabus Spring 2017
120:356 Molecular Biology
SCHEDULE AND COURSE OUTLINE: Dates listed by week; lectures will meet twice every week. Weekly dates
of quizzes and due dates for written projects are listed. Due dates for these assignments will be regularly
updated on the course Blackboard site.
DATE
MEETING TOPIC
NOTES/READING
ASSIGNMENTS/EXAMS
1/18
Cells and Organisms
Chapter 1
1/20
Basic Genetics
Chapter 2
1/25
DNA, RNA, and Proteins
Chapter 3
1/27
Genomes and DNA
Chapter 4
2/1
Manipulation of Nucleic Acids
Chapter 5
2/3
Polymerase Chain Reaction
Chapter 6
2/8
Cloning Genes for Analysis
Chapter 7
2/10
DNA Sequencing
Chapter 8
2/15
Exam 1
Chapters 1-7
2/17
Genomics & Systems Biology
Chapter 9
2/22
Cell Division and DNA Replication
Chapter 10
2/24
Transcription of Genes
Chapter 11
3/1
Processing of RNA
Chapter 12
3/3
Protein Synthesis
Chapter 13
3/8
Protein Structure and Function
Chapter 14
3/10
Proteomics: The Global Analysis of Proteins
Chapter 15
3/22
Regulation of Transcription in Prokaryotes
Chapter 16
3/24
Exam II
Chapters 8-15
3/29
Regulation of Transcription in Eukaryotes
Chapter 17
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3/31
Regulation at the RNA Level
Chapter 18
4/5
Analysis of Gene Expression
Chapter 19
4/7
Plasmids
Chapter 20
4/12
Viruses
Chapters 21
4/14
Mobile DNA Mutation and Repair
Chapters 22 & 23
4/19
Mobile DNA Mutation and Repair
Chapters 22 & 23
4/21
Exam III
Chapters 16-22 & 23
4/25
Recombination
Chapter 24
4/27
Course Overview
Chapters 1-24
DATE OF FINAL EXAM: FRIDAY MAY 5TH, 8:30 – 11:30 AM
GRADING POLICY:
Your grade for this course will be determined based on the categories listed in the table below.
Average of top two semester exam
grades (the lowest semester exam
grade is dropped)
70 %
Final Exam
TOTAL
30 %
100 %
Percentages are converted to letter grades according to University policy, and follow the distribution
given below:
Final %
Letter
< 59.49
59.5–69.49
69.5-74.49
75.5-79.49
79.5-84.49
84.5-89.49
89.5-100
F
D
C
C+
B
B+
A
Failing
Poor
Satisfactory
Good
Excellent
Outstanding
ATTENDANCE, MAKE-UP, AND LATENESS POLICY:
Attendance is highly encouraged. If you must miss class for a valid reason, please discuss what material
was missed with your instructor as soon as possible. Exam attendance policy: No one will be allowed to
start an exam after 15-minutes from the start time of the exam! No exceptions. There are NO make-up
exams in this course; if you miss an exam then it will be counted as your dropped grade (Note: Everyone
must take the final exam).
Academic Dishonesty: The course has a zero tolerance policy for academic dishonesty, including
plagiarism and cheating. Instances of dishonesty will be punished by a zero on the assignment and
consultation with the Academic Integrity Officers to determine if further action is required. If you have
any questions about what constitutes plagiarism or cheating, please ask your instructors or refer to the
academic integrity websites for Rutgers and NJIT:
!
!
!
http://academicintegrity.rutgers.edu/academic-integrity-at-rutgers
http://studentconduct.rutgers.edu/
http://www.njit.edu/academics/integrity.php
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