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Study Questions – Chapter 11 1. 2. 3. 4. 5. What is a genetic map? What is a genetic marker? What are three different kinds of genetic markers? What does it mean when we say that we have “found a gene”? What are two advantages of single nucleotide polymorphisms (SNPs) over restriction fragment length polymorphisms (RFLPs)? 6. Why did scientists use blood group markers in so many of the earliest efforts to map human genes? 7. When constructing a genetic map, why is it a problem if the founder is homozygous? 8. Which allele is linked with the trait represented by the blue symbols? 9. Why can’t we tell whether this marker and this trait are linked? 10. Draw a map showing where the following markers are located relative to each other: 11. Where is trait A relative to markers B, F and P? 12. What information do we get from the recombination fraction and what information do we get from the LOD score? 13. Markers D and J show 50% recombination. Where are they located relative to each other? 14. If we use human DNA to paint elephant and gibbon chromosomes, we see that the same pale blue color paints elephant chromosome 27 and gibbon chromosome 21. What can we conclude about the relationship between elephant chromosome 27 and gibbon chromosome 21? Copyright © 2011, Elsevier Inc. All rights reserved. 1 15. In the late 1980s when the Huntington disease gene was mapped, it took years afterwards to find the gene. After the turn of the century, when the progeria gene was mapped, it took less than a year to find the gene. What had changed that made such a big difference in the timelines of these two projects? 16. What information can help evaluate the list of potential candidate genes located in the region to which a gene has been mapped? 17. How can an animal model be used to find a human disease gene? 18. Using genetic markers, you find that the interval containing the gene is flanked by marker G and marker H. You identify the genes located between markers G and H and find a gene with a sequence variant that co-segregates with the disease. Meanwhile another group has tested a different gene and found the same thing for that gene. Why would two different groups find two different genes that cosegregate with the disease? 19. If defects in a particular gene cause the disease we are studying in a human family, why might that same defect not cause the disease in a mouse? 20. Why does the genetic distance of 1 cm not always correspond with the physical distance of 1 million bases? Copyright © 2011, Elsevier Inc. All rights reserved. 2