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Molecular Genetics Review - Biology 12U Chapter 7: Nucleic Acids: The Molecular Basis of Life material of heredity - components or RNA and DNA *5 people in the book who are important for DNA history : Watson and Crick; Franklin; Chargaff; Meishner; and Griffith. structure of nucleic acids organiztion of genetic material in prokaryotes and eukaryotes (directionality, purine, pyrimidine, complementary, antiparallel, supercoiled, plasmid, histone, chromatin, nucleosome) how DNA packs itself into small space DNA replication conservative, semi-conservative, and dispersive theories process- initiation, elongation,termination be able to draw a diagram for it and explain your diagram terms – replication origin, DNA polymerase, replication fork,helicases, primer, Okazaki fragment,leading strand,lagging strand, DNA ligase, telomeres Genes and the genome exons and introns pseudogenes ethical and social implications of genetic knowledge Chapter 8: Protein Synthesis and Gene Expression Central Dogma and Genetic Code Crick- triplet hypothesis, “central dogma” codons – maximum combinations transfer of genetic information genetic code- continuity, redundancy, universality From DNA to RNA – transcription initiation, elongation, termination terms- messenger RNA, sense strand, anti-sense strand, promoter sequence,RNA polymerase, precursor RNA, 5'cap, poly-A tail, spliceosome, small nuclear RNA From RNA to Protein: Translation transfer RNA – structure initiation, elongation, termination The regulation of Gene Expression in prokaryotic cells and in eukaryotic cells Chapter 9: DNA Mutations and Genetic Engineering Mutations and Mutagens types of mutations – nucleotide substitutions, nucleotide insertions or deletions, chromosomal mutations causes of mutations physical, chemical and cumulative mutations mutation repair The sequence of life Review questions p. 319 # 1-3, 5, 7, 13 p. 329 # 1-18 try multiple choice questions.