Download Molecular Genetics Review - Biology 12U Chapter 7: Nucleic Acids

Molecular Genetics Review - Biology 12U
Chapter 7: Nucleic Acids: The Molecular Basis of Life
material of heredity - components or RNA and DNA
*5 people in the book who are important for DNA history : Watson and Crick;
Franklin; Chargaff; Meishner; and Griffith.
structure of nucleic acids
 organiztion of genetic material in prokaryotes and eukaryotes
(directionality, purine, pyrimidine, complementary, antiparallel,
supercoiled, plasmid, histone, chromatin, nucleosome)
 how DNA packs itself into small space
DNA replication
 conservative, semi-conservative, and dispersive theories
 process- initiation, elongation,termination
 be able to draw a diagram for it and explain your diagram
 terms – replication origin, DNA polymerase, replication fork,helicases,
primer, Okazaki fragment,leading strand,lagging strand, DNA ligase,
telomeres
Genes and the genome
 exons and introns
 pseudogenes
 ethical and social implications of genetic knowledge
Chapter 8: Protein Synthesis and Gene Expression
Central Dogma and Genetic Code
 Crick- triplet hypothesis, “central dogma”
 codons – maximum combinations
 transfer of genetic information
 genetic code- continuity, redundancy, universality
From DNA to RNA – transcription
 initiation, elongation, termination
 terms- messenger RNA, sense strand, anti-sense strand, promoter
sequence,RNA polymerase, precursor RNA, 5'cap, poly-A tail,
spliceosome, small nuclear RNA
From RNA to Protein: Translation
 transfer RNA – structure
 initiation, elongation, termination
The regulation of Gene Expression
 in prokaryotic cells and in eukaryotic cells
Chapter 9: DNA Mutations and Genetic Engineering
Mutations and Mutagens
 types of mutations – nucleotide substitutions, nucleotide insertions or
deletions, chromosomal mutations
 causes of mutations
 physical, chemical and cumulative mutations
 mutation repair
The sequence of life
Review questions p. 319 # 1-3, 5, 7, 13
p. 329 # 1-18 try multiple choice questions.