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Haldia Institute of Technology Department of Food Technology COURSE INFORMATION Course Code: FT401 Course Name: Biochemistry and Nutrition Contacts: 4 hours (3 lectures & 1 tutorial) Credits: 4 COURSE OUTCOME At the end of this course, the incumbent will be able to: FT401.1 Apply principles of mathematical, natural science, and engineering science to identify, research, analyze, and formulate substantiated solution of complex practical food & biochemical technology problems. FT401.2 Design and develop solutions for practical engineering problems related to food, chemical & biochemical industries, and design system components or processes that meet specified needs with appropriate consideration for public health and safety, societal, and environmental considerations. FT401.3 Design basic engineering processes along with products to meet societal needs within realistic constraints such as economic, environmental, ethical, cultural, human nutrition, feasibility, and sustainability. FT401.4: Ability to create, select, and apply appropriate knowledge, techniques, resources with a view of modern engineering, instrumental and computational tools, including prediction and modeling to different Biochemical reactions, with an understanding of the limitations FT401.5: Ability to communicate effectively on professional activities with the engineering community to function effectively as an individual or leader in diverse teams in multi-disciplinary settings FT401.6: Apply principles related to complex food solutions, its structural & functional stability and other parameters to ensure its safety in different processing treatments, as an industrial professional fulfilling principles of professional ethics, responsibilities, and norms of engineering practice PREREQUISITES To understand this course, the incumbentmust have idea of: Basic elemental knowledge in biochemistry Basic understanding of structure and bonding Knowledge on principles related to structure, function and metabolism of protein, carbohydrate and fat derived different food products Basic knowledge on human nutrition and biochemical/metabolic pathway SYLLABI Module I (10L): Introduction to Biochemistry. Proteins and protein structures; Essential amino acids. Metabolism of proteins (digestion and absorption); Nitrogen balance and nitrogen pool; Evaluation of quality of proteins Module II (10L): Enzymes; Definition, function, classification, nomenclature & structure; Co-enzymes and its function; Mechanism of enzyme action, enzyme kinetics & environmental effects; Enzyme inhibition. Module III (10L): Carbohydrates; Definition & classification; General chemistry of carbohydrates; Metabolic pathways for breakdown of carbohydrates: glycolytic pathway, pentose phosphate pathway, citric acid cycle, electron transport chain, ATP balance, gluconeogenesis; General chemistry of lipids; Essential fatty acids; Digestion & absorption of lipids. Module IV (10L): Vitamins & minerals: occurrence, physiological function of vitamins and minerals. Introduction to human nutrition; Nutritive values of foods; Basal metabolic rate; Techniques for assessment of human nutrition, Dietary requirements and deficiency diseases of different nutrients BEYOND SYLLABI COVERAGE Basic idea about the human digestive system Advanced instrumental methods and its applications for food analysis Importance of instrumental techniques for food industries Case study based on stability of Proteins, enzymes including basic knowledge of its stability and energy calculation Relative thermodynamic stability of different Biochemical compounds LECTURE PLAN LectureNo. Details of coverage Handout, Lecture Notes, Links etc. Slide Presentation 2 Orientation lectures: Why do the students need to study the course, what are the outcomes after studying the course and how these outcomes correlate with the expected outcome of the programmed they enrolled in Syllabus and teaching modules 3 Basic things related to biochemistry Handout History, Definition and function of proteins Proteins classification and their structure: primary, secondary and tertiary Essential and non essential amino acid Lecture notes and book chapter 1 4 5 6 Handout Lecture notes Lecture notes and book chapter 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Digestion of proteins Absorption of proteins Nitrogen balance and nitrogen pool Ornithine cycle, Different nitrogenous end product Evaluation of protein History, Definition and function of enzymes, Isoelectric points Classification of enzymes Nomenclature, EC code and Structure of enzymes Coenzyme, prosthetic groups, cofactor and its function Mechnism of enzyme action like Lock and key hypothesis Induced fit model Enzyme kinetics , Transition theory, MME, WH plot LB plot, EH plot Environmental effect on enzyme activity Competitive and noncompetitive inhibition by enzyme and their effects on enzyme activity Uncompetitive inhibition by enzyme and their effects on enzyme activity History, definition and classification of carbohydrates Physical and chemical properties of carbohydrate Metabolic pathway for breakdown of carbohydrate like glycolytic pathway Pentose phosphate pathway and citric acid cycle Electron Transport System and ATP balance 28 Inhibitors of different metabolic pathway 29 30 Gluconeogenesis Glucose-Alanine cycle, Cori cycle and their Handbook prepared from Biochemistry book Lecture notes Lecture notes and book chapter Handout from Biochemistry book, Lehingers Lecture notes and book chapter Lecture notes and book chapter Lecture notes Lecture notes Lecture notes Lecture notes and book chapter Handout from Biochemistry book, Voet and Voet Lecture notes Lecture notes Lecture notes Handout from Biochemistry book, Voet and Voet Lecture notes Handout Handout Slide presentation Lecture notes Slide presentation Handout from Biochemistry book, Voet and Voet Slide presentation Handout from Biochemistry importance book, Voet and Voet History, definition and classification of 31 Handout Lipids 32 Essential and non essential lipids Handout General physical and chemical properties 33 Handout of lipid 34 Classification of lipids and their function Lecture notes Digestion of lipid by enzymes in digestive 35 Lecture notes system 36 Absorption of lipids in intestine Lecture notes 37 β-oxidation of lipids Slide presentation Discussion about different derivatives of 38 Handout lipid and their function Occurrence and source of Vitamines and 39 Handout Minerals Physiological functions of Vitamines and 40 Lecture notes Minerals Human Nutrition and Nutritive values of 41 Handout foods 42 Basal Metabolic Rate Handout Techniques for assessment of human 43 Handout nutrion like NPU, PER, RQ etc. 44 Dietary Requirement of nutrition Lecture notes 45 Deficiency diseases different nutrients Lecture notes *Minimum 36 lectures for 3 contact courses and 48 lectures for 4 contact courses RECOMMENDED READINGS TEXT 1. NCERT class XII 2. Fundamental of Biochemistry by Voet and Voet 3. Aakash Institute material 4. Principles of Biochemistry by Lehinger 5. Chemistry, O.P.Agrawal REFERENCES 1. Modern Experimental Biochemistry, Boyer, Pearson Education 2. Organic Chemistry, Vol-2 by I.L.Finar 3. Lubert stryer, Biochemistry, Freeman & Co, N.Y 4. HamesNutrition and dietetics by Rose