Download Leukaemia Section t(9;11)(q34;p15) Atlas of Genetics and Cytogenetics in Oncology and Haematology

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
OPEN ACCESS JOURNAL AT INIST-CNRS
Leukaemia Section
Short Communication
t(9;11)(q34;p15)
Jean-Loup Huret
Genetics, Dept Medical Information, UMR 8125 CNRS, University of Poitiers, CHU Poitiers Hospital, F86021 Poitiers, France (JLH)
Published in Atlas Database: January 2005
Online updated version : http://AtlasGeneticsOncology.org/Anomalies/t0911q34p15ID1380.html
DOI: 10.4267/2042/38159
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2005 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Clinics and pathology
Protein
Class II homeobox gene.
Disease
NUP98
Acute myelomonocytic leukemia (M4 ANLL).
Location
11p15.4
Protein
Nucleoporin 98, a 98 kDa component of the nuclear
pore complex implicated in nucleo-cytoplasmic
transport.
Etiology
This leukemia case is likely to be treatment related (a
lymphoma was treated 4 years previously).
Epidemiology
Only one case to date: a 65-year-old female patient.
Prognosis
Result of the chromosomal
anomaly
No data.
Genes involved and proteins
Hybrid gene
PRRX2
Description
5'--> exon 11 of NUP98 is fused in frame with PRRX2
exon 2 to 3'.
Location
9q34
Atlas Genet Cytogenet Oncol Haematol. 2005; 9(1)
37
t(9;11)(q34;p15)
Huret JL
References
This article should be referenced as such:
Huret JL. t(9;11)(q34;p15). Atlas Genet Cytogenet Oncol
Haematol. 2005; 9(1):37-38.
Gervais C, Mauvieux L, Perrusson N, Hélias C, Struski S,
Leymarie V, Lioure B, Lessard M. A new translocation
t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner
gene, PRRX2, in a therapy-related acute myeloid leukemia.
Leukemia. 2005 Jan;19(1):145-8
Atlas Genet Cytogenet Oncol Haematol. 2005; 9(1)
38