Download Lesson 12.2 PPT - Freeman Public Schools

PowerPoint® Lecture Slide Presentation
by Patty Bostwick-Taylor,
Florence-Darlington Technical College
The Lymphatic
System and
Body Defenses
12
PART B
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Immune response is the immune system’s
response to a threat
 Immunology is the study of immunity
 Antibodies are proteins that protect from
pathogens
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Three aspects of adaptive defense
 Antigen specific—recognizes and acts against
particular foreign substances
 Systemic—not restricted to the initial infection
site
 Memory—recognizes and mounts a stronger
attack on previously encountered pathogens
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Types of Immunity
 Humoral immunity = antibody-mediated
immunity
 Provided by antibodies present in body
fluids
 Provided by B lymphocytes
 Cellular immunity = cell-mediated immunity
 Targets virus-infected cells, cancer cells,
and cells of foreign grafts
 Provided by T lymphocytes
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Antigens (nonself)
 Any substance capable of exciting the
immune system and provoking an immune
response
 Examples of common antigens
 Foreign proteins (strongest)
 Nucleic acids
 Large carbohydrates
 Some lipids
 Pollen grains
 Microorganisms
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Self-antigens
 Human cells have many surface proteins
 Our immune cells do not attack our own
proteins
 Our cells in another person’s body can trigger
an immune response because they are foreign
 Restricts donors for transplants
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Allergies
 Many small molecules (called haptens or
incomplete antigens) are not antigenic, but
link up with our own proteins
 The immune system may recognize and
respond to a protein-hapten combination
 The immune response is harmful rather than
protective because it attacks our own cells
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Cells of the adaptive defense system
 Lymphocytes respond to specific antigens
 B lymphocytes (B cells)
 Produce antibodies and oversees
humoral immunity
 T lymphocytes (T cells)
 Cell-mediated immunity
 Macrophages help lymphocytes
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Immunocompetent—cell becomes capable of
responding to a specific antigen by binding to it
 Cells of the adaptive defense system
 Lymphocytes
 Originate from hemocytoblasts in the red
bone marrow
 B lymphocytes become immunocompetent
in the bone marrow (remember B for Bone
marrow)
 T lymphocytes become immunocompetent
in the thymus (remember T for Thymus)
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Lymphocyte Differentiation and Activation
Lymphocytes destined to become T cells
migrate from bone marrow to the thymus
and develop immunocompetence there.
B cells develop immuno-competence in
the bone marrow.
Bone marrow
Circulation
in blood
Immature
lymphocytes
Thymus
Immunocompetent,
but still naive,
lymphocytes
migrate via blood
Mature
immunocompetent
B and T cells
recirculate in
blood and lymph
After leaving the thymus or bone marrow
as naive immunocompetent cells,
lymphocytes “seed” the infected
connective tissues (especially lymphoid
tissue in the lymph nodes), where the
antigen challenge occurs and the
lymphocytes become fully activated.
Bone marrow
Activated (mature) lymphocytes circulate
continuously in the bloodstream and
lymph, and throughout the lymphoid
organs of the body.
Lymph nodes
and other
lymphoid tissues
KEY:
Site of lymphocyte origin
and
Sites of development of
immunocompetence as B
or T cells; primary lymphoid organs
Site of antigen challenge and final
differentiation to mature B and T cells
Figure 12.11
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Lymphocyte Differentiation and Activation
Lymphocytes destined to become T cells
migrate from bone marrow to the thymus
and develop immunocompetence there.
Bone marrow
Circulation
in blood
Immature
lymphocytes
Thymus
KEY:
Site of lymphocyte origin
and
Sites of development of
immunocompetence as B
or T cells; primary lymphoid organs
Site of antigen challenge and final
differentiation to mature B and T cells
Figure 12.11, step 1a
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Lymphocyte Differentiation and Activation
Lymphocytes destined to become T cells
migrate from bone marrow to the thymus
and develop immunocompetence there.
B cells develop immuno-competence in
the bone marrow.
Bone marrow
Circulation
in blood
Thymus
Immature
lymphocytes
Bone marrow
KEY:
Site of lymphocyte origin
and
Sites of development of
immunocompetence as B
or T cells; primary lymphoid organs
Site of antigen challenge and final
differentiation to mature B and T cells
Figure 12.11, step 1b
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Lymphocyte Differentiation and Activation
Lymphocytes destined to become T cells
migrate from bone marrow to the thymus
and develop immunocompetence there.
B cells develop immuno-competence in
the bone marrow.
Bone marrow
Circulation
in blood
Immature
lymphocytes
Thymus
Immunocompetent,
but still naive,
lymphocytes
migrate via blood
After leaving the thymus or bone marrow
as naive immunocompetent cells,
lymphocytes “seed” the infected
connective tissues (especially lymphoid
tissue in the lymph nodes), where the
antigen challenge occurs and the
lymphocytes become fully activated.
Bone marrow
Lymph nodes
and other
lymphoid tissues
KEY:
Site of lymphocyte origin
and
Sites of development of
immunocompetence as B
or T cells; primary lymphoid organs
Site of antigen challenge and final
differentiation to mature B and T cells
Figure 12.11, step 2
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Lymphocyte Differentiation and Activation
Lymphocytes destined to become T cells
migrate from bone marrow to the thymus
and develop immunocompetence there.
B cells develop immuno-competence in
the bone marrow.
Bone marrow
Circulation
in blood
Immature
lymphocytes
Thymus
Immunocompetent,
but still naive,
lymphocytes
migrate via blood
Mature
immunocompetent
B and T cells
recirculate in
blood and lymph
After leaving the thymus or bone marrow
as naive immunocompetent cells,
lymphocytes “seed” the infected
connective tissues (especially lymphoid
tissue in the lymph nodes), where the
antigen challenge occurs and the
lymphocytes become fully activated.
Bone marrow
Activated (mature) lymphocytes circulate
continuously in the bloodstream and
lymph, and throughout the lymphoid
organs of the body.
Lymph nodes
and other
lymphoid tissues
KEY:
Site of lymphocyte origin
and
Sites of development of
immunocompetence as B
or T cells; primary lymphoid organs
Site of antigen challenge and final
differentiation to mature B and T cells
Figure 12.11, step 3
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Adaptive Defense System: Third Line of Defense
 Cells of the adaptive defense system (continued)
 Macrophages
 Arise from monocytes
 Become widely distributed in lymphoid
organs
 Secrete cytokines (proteins important in
the immune response)
 Tend to remain fixed in the lymphoid
organs
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Functions of Cells and
Molecules Involved in Immunity
Table 12.3 (2 of 2)
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral (Antibody-Mediated) Immune Response
 Stage One of B cell development
 Inactive B cells are released from bone
marrow and circulate to lymph nodes, spleen
and other lymphatic structures
 Stage Two is when B cell becomes activated
 B lymphocytes with specific receptors bind to
a specific antigen
 One the antigen is an epitope
 Epitope is protein molecule that has a
sequence that determines its shape
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral (Antibody-Mediated) Immune Response
 The binding event activates the lymphocyte to
undergo clonal selection
 Family of identical B cells are produced
 A large number of clones are produced (primary
humoral response)
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral Immune Response
 Most B cells become plasma cells
 Produce antibodies to destroy antigens
 Activity lasts for 4 or 5 days
 Some B cells become long-lived memory cells
(secondary humoral response)
 A Second exposure causes a rapid response
 Secondary response is stronger and lasts
longer
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral Immune Response
Primary Response
(initial encounter
with antigen)
B lymphoblasts
Proliferation to
form a clone
Antigen
Antigen binding
to a receptor on a
specific B cell
(lymphocyte)
(B cells with
non-complementary
receptors remain
inactive)
Plasma
cells
Memory
B cell
Secreted
antibody
molecules
Secondary Response
(can be years later)
Subsequent challenge
by same antigen
Clone of cells
identical to
ancestral cells
Plasma
cells
Secreted
antibody
molecules
Memory
B cells
Figure 12.12
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral Immune Response
Primary Response
(initial encounter
with antigen)
Antigen
Antigen binding
to a receptor on a
specific B cell
(lymphocyte)
(B cells with
non-complementary
receptors remain
inactive)
Figure 12.12, step 1
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral Immune Response
Primary Response
(initial encounter
with antigen)
B lymphoblasts
Proliferation to
form a clone
Antigen
Antigen binding
to a receptor on a
specific B cell
(lymphocyte)
(B cells with
non-complementary
receptors remain
inactive)
Figure 12.12, step 2
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral Immune Response
Primary Response
(initial encounter
with antigen)
B lymphoblasts
Proliferation to
form a clone
Antigen
Antigen binding
to a receptor on a
specific B cell
(lymphocyte)
(B cells with
non-complementary
receptors remain
inactive)
Plasma
cells
Memory
B cell
Secreted
antibody
molecules
Figure 12.12, step 3
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral Immune Response
Primary Response
(initial encounter
with antigen)
B lymphoblasts
Proliferation to
form a clone
Antigen
Antigen binding
to a receptor on a
specific B cell
(lymphocyte)
(B cells with
non-complementary
receptors remain
inactive)
Plasma
cells
Memory
B cell
Secreted
antibody
molecules
Secondary Response
(can be years later)
Subsequent challenge
by same antigen
Clone of cells
identical to
ancestral cells
Figure 12.12, step 4
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral Immune Response
Primary Response
(initial encounter
with antigen)
B lymphoblasts
Proliferation to
form a clone
Antigen
Antigen binding
to a receptor on a
specific B cell
(lymphocyte)
(B cells with
non-complementary
receptors remain
inactive)
Plasma
cells
Memory
B cell
Secreted
antibody
molecules
Secondary Response
(can be years later)
Subsequent challenge
by same antigen
Clone of cells
identical to
ancestral cells
Plasma
cells
Secreted
antibody
molecules
Memory
B cells
Figure 12.12, step 5
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Humoral Immune Response
Figure 12.13
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Active Immunity
 Occurs when B cells encounter antigens and
produce antibodies
 Active immunity can be
 Naturally acquired during bacterial and viral
infections
 Artificially acquired from vaccines
 Amount of antibodies produced in
response to a vaccination is called an
antibody titer
 Booster shots may intensify the immune
response at a later meeting with the same
antigen
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Passive Immunity
 Occurs when antibodies are obtained from
someone else
 Conferred naturally from a mother to her fetus
(naturally acquired)
 Conferred artificially from immune serum or
gamma globulin (artificially acquired)
 Immunological memory does not occur
 Protection provided by “borrowed antibodies”
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Passive Immunity
 Monoclonal antibodies
 Antibodies prepared for clinical testing or
diagnostic services
 Produced from descendents of a single cell
line
 Examples of uses for monoclonal antibodies
 Diagnosis of pregnancy
 Treatment after exposure to hepatitis and
rabies
 Inherited Immunity- immunity you are born with
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Types of Acquired Immunity
Figure 12.14
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Antibodies (Immunoglobulins or Igs)
 Soluble proteins secreted by B cells (plasma
cells)
 Carried in blood plasma
 Capable of binding specifically to an antigen
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Antibodies (Immunoglobulins or Igs)
Figure 12.15a
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Antibodies
 Antibody structure
 Four amino acid chains linked by disulfide
bonds
 Two identical amino acid chains are linked to
form a heavy chain- 400 amino acids
 The other two identical chains are light chains
 Specific antigen-binding sites are present
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Antibody Structure
Figure 12.15b
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Antibodies
 It is Y shaped and the ends have variable regions
 Variable region is region where the sequence
varies in different antibodies (epitope)
 Also has a complement binding site
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Antibodies
 Antibody classes
 Antibodies of each class have slightly
different roles
 Five major immunoglobulin classes (MADGE)
 IgM—can fix complement
 IgA—found mainly in mucus, saliva, tears
 IgD—important in activation of B cell
 IgG—can cross the placental barrier and
fix complement and is most abundant
 IgE—involved in allergies
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Immunoglobin Classes
Table 12.2
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Antibodies
 Antibody function
 Antibodies inactivate antigens in a number of
ways
 Neutralization-antibodies bind to specific
sites on bacteria and viruses and turns
them into harmless cells
 Agglutination- clumping so easy for
phagocytosis; happens in blood mixing
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Antibodies
 Antibody function
 Complement fixation- alters shape of
antibody to expose previously hidden
complement site
 Binding to these sites causes a hole in
the middle of the enemy cell and water
runs in and cell bursts
 cytolosis
 Precipitation
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Antibody Function
Figure 12.16
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Cellular (Cell-Mediated) Immune Response
 Antigens must be presented by macrophages to
an immunocompetent T cell (antigen
presentation)
 T cells must recognize nonself and self (double
recognition)
 After antigen binding, clones form as with B cells,
but different classes of cells are produced
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Cellular (Cell-Mediated) Immune Response
Figure 12.17
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Cellular (Cell-Mediated) Immune Response
 T cell clones
 Cytotoxic (killer) T cells
 Specialize in killing infected cells
 Insert a toxic chemical (perforin)
 Helper T cells
 Recruit other cells to fight the invaders
 Interact directly with B cells to
differentiate into plasma cells
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Cellular (Cell-Mediated) Immune Response
Figure 12.18
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Cellular (Cell-Mediated) Immune Response
 T cell clones (continued)
 Regulatory T cells
 Formerly called suppressor T cells
 Release chemicals to suppress the activity
of T and B cells
 Stop the immune response to prevent
uncontrolled activity
 A few members of each clone are memory
cells
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Functions of Cells and Molecules
Involved in Immunity
Table 12.3 (1 of 2)
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Functions of Cells and Molecules
Involved in Immunity
Table 12.3 (2 of 2)
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Summary of Adaptive Immune Response
Figure 12.19
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Summary of Adaptive Immune Response
Figure 12.19 (1 of 2)
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Summary of Adaptive Immune Response
Figure 12.19 (2 of 2)
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Organ Transplants and Rejection
 Major types of grafts
 Autografts—tissue transplanted from one site
to another on the same person
 Isografts—tissue grafts from an identical
person (identical twin)
 Allografts—tissue taken from an unrelated
person
 Xenografts—tissue taken from a different
animal species
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Organ Transplants and Rejection
 Autografts and isografts are ideal donors
 Xenografts are never successful
 Allografts are more successful with a closer
tissue match
 Immunosuppressive therapy needed to
prevent rejection
 Includes drugs, radiation, and controlling
inflammation
 May have side effects
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Organ Transplants and Rejection
 Host vs. Graft rejection- destroys donated tissue
 Graft vs. Host rejection- destroys tissue in hosts
body and may lead to death
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Disorders of Immunity:
Allergies (Hypersensitivity)
 Abnormal, vigorous immune responses
 Types of allergies
 Immediate hypersensitivity
 Triggered by release of histamine from IgE
binding to mast cells
 Reactions begin within seconds of contact
with allergen
 Runny nose, watery eyes, itching, hives,
constricted airways, irregular heart beat
 Antihistimines may help
 When allergen inhaled- asthma
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Disorders of Immunity:
Allergies (Hypersensitivity)
 Anaphylactic shock—dangerous, systemic
response
 Occurs when allergen enters the blood
and rapidly circulates through body
 Bee stings and spider bites
 Can happen with penicillin in some people
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Disorders of Immunity:
Allergies (Hypersensitivity)
 Types of allergies (continued)
 Delayed hypersensitivity
 Triggered by the release of lymphokines
from activated helper T cells
 Symptoms usually appear 1–3 days after
contact with antigen
 Use corticosteroid drugs
 Contact dermatitis (poison ivy), cosmetics,
detergents
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Allergy Mechanisms
Sensitization stage
Antigen (allergen)
invades body
Plasma cells
produce large
amounts of class
IgE antibodies
against allergen
IgE antibodies
attach to mast
cells in body
tissues (and to
circulating
basophils)
Mast cell with
fixed IgE
antibodies
IgE
Granules
containing
histamine
Subsequent
(secondary)
responses
More of
same allergen
invades body
Allergen
binding to IgE
on mast cells
triggers release of
histamine (and
other chemicals)
Antigen
Mast cell
granules release
contents after
antigen binds
with IgE
antibodies
Histamine
Histamine causes blood vessels to dilate and
become leaky, which promotes edema;
stimulates release of large amounts of mucus;
and causes smooth muscles to contract
Outpouring
of fluid from
capillaries
Release of
mucus
Constriction of
bronchioles
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Figure 12.20
Allergy Mechanisms
Sensitization stage
Antigen (allergen)
invades body
Figure 12.20, step 1
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Allergy Mechanisms
Sensitization stage
Antigen (allergen)
invades body
Plasma cells
produce large
amounts of class
IgE antibodies
against allergen
Figure 12.20, step 2
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Allergy Mechanisms
Sensitization stage
Antigen (allergen)
invades body
Plasma cells
produce large
amounts of class
IgE antibodies
against allergen
IgE antibodies
attach to mast
cells in body
tissues (and to
circulating
basophils)
Mast cell with
fixed IgE
antibodies
IgE
Granules
containing
histamine
Figure 12.20, step 3
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Allergy Mechanisms
Subsequent
(secondary)
responses
More of
same allergen
invades body
Antigen
Figure 12.20, step 4
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Allergy Mechanisms
Subsequent
(secondary)
responses
More of
same allergen
invades body
Allergen
binding to IgE
on mast cells
triggers release of
histamine (and
other chemicals)
Antigen
Mast cell
granules release
contents after
antigen binds
with IgE
antibodies
Histamine
Figure 12.20, step 5
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Allergy Mechanisms
Subsequent
(secondary)
responses
Antigen
More of
same allergen
invades body
Allergen
binding to IgE
on mast cells
triggers release of
histamine (and
other chemicals)
Mast cell
granules release
contents after
antigen binds
with IgE
antibodies
Histamine
Histamine causes blood vessels to dilate and
become leaky, which promotes edema;
stimulates release of large amounts of mucus;
and causes smooth muscles to contract
Outpouring
of fluid from
capillaries
Release of
mucus
Constriction of
bronchioles
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Figure 12.20, step 6
Allergy Mechanisms
Sensitization stage
Antigen (allergen)
invades body
Plasma cells
produce large
amounts of class
IgE antibodies
against allergen
IgE antibodies
attach to mast
cells in body
tissues (and to
circulating
basophils)
Mast cell with
fixed IgE
antibodies
IgE
Granules
containing
histamine
Subsequent
(secondary)
responses
More of
same allergen
invades body
Allergen
binding to IgE
on mast cells
triggers release of
histamine (and
other chemicals)
Antigen
Mast cell
granules release
contents after
antigen binds
with IgE
antibodies
Histamine
Histamine causes blood vessels to dilate and
become leaky, which promotes edema;
stimulates release of large amounts of mucus;
and causes smooth muscles to contract
Outpouring
of fluid from
capillaries
Release of
mucus
Constriction of
bronchioles
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Figure 12.20, step 7
Disorders of Immunity: Immunodeficiencies
 Production or function of immune cells or
complement is abnormal
 May be congenital or acquired
 Includes AIDS (Acquired Immune Deficiency
Syndrome) and Severe Combined
Immunodeficiency Disease (SCID)
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Disorders of Immunity:
Autoimmune Diseases
 The immune system does not distinguish between
self and nonself
 The body produces antibodies and sensitized T
lymphocytes that attack its own tissues
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Disorders of Immunity:
Autoimmune Diseases
 Examples of autoimmune diseases
 Multiple sclerosis—white matter of brain and
spinal cord are destroyed
 Myasthenia gravis—impairs communication
between nerves and skeletal muscles
 Type I diabetes mellitus—destroys pancreatic
beta cells that produce insulin
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Disorders of Immunity:
Autoimmune Diseases
 Examples of autoimmune diseases
 Rheumatoid arthritis—destroys joints
 Systemic lupus erythematosus (SLE)
 Affects kidney, heart, lung and skin
 Glomerulonephritis—impairment of renal
function
 Reynaud’s Disease
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Self Tolerance Breakdown
 Inefficient lymphocyte programming
 Appearance of self-proteins in the circulation that
have not been exposed to the immune system
 Eggs
 Sperm
 Eye lens
 Proteins in the thyroid gland
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Self Tolerance Breakdown
 Cross-reaction of antibodies produced against
foreign antigens with self-antigens
 Rheumatic fever
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Developmental Aspects of the
Lymphatic System and Body Defenses
 Except for thymus and spleen, the lymphoid
organs are poorly developed before birth
 A newborn has no functioning lymphocytes at
birth, only passive immunity from the mother
 If lymphatics are removed or lost, severe edema
results, but vessels grow back in time
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