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reign invaders - viruses, bacteria, allergens, toxins and rasites- constantly bombard our body. 27 YOUR ACTIVE IMMUNE DEFENSES Innate Immunity Adaptive Immunity - invariant (generalized) - early, limited specificity - the first line of defense - variable (custom) - later, highly specific - ââremembersââ infection 1. Barriers - skin, tears 2. Phagocytes - neutrophils, macrophages 3. NK cells and mast cells 4. Complement and other proteins