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Transcript
Overview of the Immune System A Historical perspective First Historical reference Thucydides, first refers to immunity describing a plaque in Athens (430 BC) Variolation Crude attempts at immunization were made in the fifth century by the Chinese and the Turks Edward Jenner (1798) Louis Pasteur Proved that Vaccination works Used Dubious means to conduct his experiment Father of Microbiology Found vaccines for both Rabies and Anthrax a scourge of the nineteenth century Emil von Behring and Shibasaburo Kitsato (1890) provided the first insights into the mechaniism of immunity. They demonstrated that SERUM (THE NONCELLULAR PORTION OF BLOOD) could transfer the immune state to unimmunized host. This component could neutralize toxins, precipitate toxins, rupture (lyse) bacteria and agglutinate bacteria Antibody Phagocytes: White Blood Cells Cell Mediated Immunity Humoral and Cell mediated Immunity were both shown to be necessary for the immune response Paul Ehrlich (1900) Clone Wars? Anatomical Barriers: Skin Skin Mucous Membrane Sebum: Sebaceous Glands Cilia Lysozyme Interferon Endocytosis Phagocytosis Pinocytosis: Cell Mediated Endocytosis Endosomes:
