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Transcript
Gametogenesis in the adult hermaphrodite of C. elegans oocyte eggs in uterus spermatheca vulva gonad Chromosome structures in the gonad of the adult hermaphrodite 0-8h: II (early embryogenesis) + III (diakinesis oocyte) 8-24h: III + IV + V + VI (diplotene to pachytene nuclei) (0- 8 h) (8 – 22< h) Egg hatchability in the wild-type hermaphrodite after X-ray irradiation Egg hatchability in the wild-type hermaphrodite after heavy ions and UV irradiation Requirement of Ce-rdh-1 & Ce-atl-1 genes for dsbreak repair system Requirement of Ce-atl-1 gene for UV-damage repair system CED3 apoptosis system is dispensable for ds-break repair system in meiotic cells. Conclusion (1) Meiotic pachytene nuclei were hyper-resistant to X-ray, 12C, and 18Ar-ion beam irradiation. (2) It suggests that general recombination activity during meiosis can effectively repair ds-breaks and gaps by X-ray, 12C, and 18Ar-ion beam irradiation. (3) A checkpoint kinase Ce-atl-1 (ATM/ATR like 1) was also involved in repair for X-ray and UV damages of mitotic and meiotic cells.