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Building Blocks of Organic Compounds Madison Southern High School Biology Unit - Biochemistry What is an organic compound? Biochemistry What are living things made of? – C, H, N, O, P, S 98% of living matter – Mn, Fe, Co, Cu, Zn electron carriers – Na, Mg, Cl, K, Ca only as ions – trace elements Why These 16? – Unique chemical properties • C, N, O: form multiple strong bonds • P: part of ATP/DNA; bonds store energy What is a polymer? • Most macromolecules are polymers – monomer – polymer – macromolecule 4 types of organic compounds Essential for all living things 1) 2) 3) 4) Carbohydrates Lipids Proteins Nucleic Acids Monosaccharides Draw the structures of the three Monosaccharides. The three structures are isomers. What does that mean? Bonds – Black Carbon – Red Hydrogen – Blue Oxygen – Green Monosaccharides GLUCOSE GALACTOSE Bonds – Black Carbon – Red Hydrogen – Blue Oxygen – Green Carbohydrates • contain C, H, O • Important because they contain a great deal of energy which is stored in the bonds • called sugar or saccharide With energy from light, plants can build sugars from carbon dioxide and water. 3 Types of Carbohydrates 1) Monosaccharide 2) Disaccharide 3) Polysaccharide 3 Types of Carbohydrates 1) Monosaccharide – monomer - Single sugar made of 5 or 6 carbon atoms Examples of Monosaccharides Glucose - main source of energy for plants and animals - metabolized during cellular respiration - plants make it during photosynthesis 2 More Monosaccharide's Fructose Galactose - Fruit sugar - milk sugar - Sweetest sugar 2. Disaccharides Two sugar molecule Examples of Disaccharides Sucrose -common table sugar -this sugar is transported throughout the plant - formed when glucose & fructose react …MORE Examples of Disaccharides Lactose - main sugar in milk - formed when glucose & galactose react Maltose - used to make beer - formed when two glucose react How to make a Disaccharide Condensation or Dehydration synthesis reactions Condensation or Dehydration Synthesis of a Disaccharide Formation of Disaccharides How to digest or break down a disaccharide? • Hydrolysis Reaction – Must use or split a water molecule Hydrolysis of a Disaccharide 3. Polysaccharides 3) Polysaccharide – Polymer - Made by condensation reactions- Bonding Many simple sugar molecules together to form the macromolecules - Can be made of 1000s of monosaccharides Examples of Polysaccharides Humans cannot digest these polysaccharides Structural Polymers Cellulose Chitin -made of long chains of glucose - major building blocks of plants -Gives strength and rigidity to plant cells -made of long chains of glucose - Composes exoskeletons of insects -Similar to cellulose. 3 Types of Carbohydrates …MORE Examples of Polysaccharides Starch Animals can digest - made of long chains of glucose - plants store extra glucose sugar as starch in roots and stems Glycogen Animals can digest -Animals store excess glucose (sugar) in the liver as glycogen -Made of long chains of glucose molecules -Glycogen is broken down to release glucose (quick energy) Storage Polymers How do digest or break down Polysaccharides? By Hydrolysis Reactions • Polysaccharides are digested by hydrolysis reactions just like disaccharides. • Must use a water molecule for each bond broken between simple sugar molecules. Examples of Carbohydrates The small black granules (dots) are glycogen. Lipids-Fats, Oils,SterolsLOOK in Monomers of Lipids your Glycerol – C3H5(OH)3 book on Saturated Fatty Acid – C5H11COOH page Unsaturated Fatty Acid – C5H9COOH 58 Bonds – Black Carbon – Red Hydrogen – Blue Oxygen – Green Lipids -Fatty Acid – monomer - COOH carboxyl group at one end (polar) - Attracted to water (hydrophilic) - Hydrocarbon end (nonpolar) - tends not to interact with water (hydrophobic) Lipids What is the difference between saturated and unsaturated fats? Solid at room temperature animal fats (bacon, lard, butter) Liquids at room temperature - olive oil, corn oil. Saturated Fats • At room temperature, saturated fats are usually solid. • Source: primarily in animal products including beef, lamb, pork and chicken, egg yolk, dairy fats of cream, milk, cheese, butter; coconut and palm oil; non-dairy creams because they contain coconut oil • Consumption of saturated fats has been linked with risk of coronary heart disease: – sources of saturated fat are full of cholesterol (except coconut and palm oil) – diet high in saturated fat facilitates cholesterol synthesis by the liver (including coconut and palm oil) Unsaturated Fats •At room temperature, unsaturated fats are usually liquid. •Monounsaturated •Sources: olive, peanut, canola, rape oil, almonds, avocado •Polyunsaturated •Sources: sunflower, soybean, corn, and safflower oil, fish oil, walnuts, sesame seeds, pumpkin seeds, tofu, lard Trans-unsaturated fatty acids (TFA) • TFA are product of hydrogenation which increases the saturation of fatty acids within oils and converts natural cis to trans configuration • Hydrogenation= industrial process that chemically transforms a low melting point oil into a solid fat with a higher melting point to enhance product taste, stability and shelf life. • Found in commercially fried foods (French fries, popcorn), commercial baked goods and snacks (cakes, cookies, biscuits), margarine, and cheap vegetable shortenings (not in e.g. Flora, Rama). • Trans-fatty acids have many adverse metabolic effects including elevation of LDL cholesterol, triglycerides, reduction in HDL cholesterol, and adverse effects on endothelial function, inflammatory markers, and probably insulin resistance. Types of Lipids Phospholipids • Lipids that are found in a membrane or barrier of a cell or cell structures - Used mainly for structure Lipids Types of Lipids Triglycerides - Energy storage - High energy molecules (twice the energy found in glucose) - Found in cells – cushions and insulates body and nerves Made from 1 glycerol + 3 fatty acid tails = triglyceride Types of Lipids Waxes - Forms a barrier for protection Waxy leaves Ear wax Types of Lipids Steroids - Ring structures (no fatty acids) - Animal hormones – testosterone, estrogen, progesterone Proteins • Polymers (polypeptides) are formed from 20 different monomers (amino acids) • Structure of an amino acid Amino Acids R groups (shaded white) determine the chemical properties of an amino acid Making a polypeptide chain •peptide bonds form between COOH and NH2 Proteins Amino acids build two types of proteins 1) Structural: This type is used in building structures in an organism 2) Chemical: This type gets involved in chemical reactions. Antibodies and enzymes perform chemical chores. Nucleic Acids - Store important information in the cell - Consist of nucleotides (monomer) Nucleotide -5 carbon sugar -Phosphate group -Nitrogen base -Adenine -Cytosine -Thymine -Guanine Nucleic Acids DNA and RNA are polymers, composed of thousands of monomers (nucleotides) Nucleic Acids DNA contains information essential for cell activities. Nucleic Acids RNA stores and transfers information necessary for making proteins. ATP: Adenosine Triphosphate A nucleotide ATP: Adenosine Triphosphate A nucleotide - Primary energy source for the cell - Key to ATP’s usefulness 3 phosphate groups Let’s Read ATP, Your Rechargeable Battery Review Carbohydrates What is the polymer? Polysaccharide Cellulose Starch Glycogen What is the monomer? Monosaccharide Review Lipids What is the polymer? Lipids What is the monomer? Fatty Acids Review Nucleic Acids What is the polymer? Nucleic Acids DNA RNA What is the monomer? Nucleotide What are the parts of a nucleotide? P BASE SUGAR Review Proteins What is the polymer? Polypeptides What is the monomer? Amino Acids