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Transcript
SPARE RECEPTORS DR. SHABANA ALI SPARE RECEPTORS Total number of receptors present compared with the number actually needed to elicit a max. biological response A pharmacological system has spare receptors if a full agonist can cause a max. response when occupying only a fraction of total receptor population Cont. Diverse molecular mechanisms responsible for spare receptor Partial agonists can become full agonist if a receptor reserve exist Spare receptor increase sensitivity t o drug If EC50 < Kd, spare receptors exist