Download Question # 1 (Multiple Answer) Concerning drug receptor interac

Question # 1 (Multiple Answer) Concerning drug receptor interactions, the constant
Kd refers to:
A) maximal physiological effect
B) maximal binding
C) the drug concentration required to occupy 50% of receptors
D) drug concentration that results in half-maximal physiological
response
E) all of the above
Question # 2 (Multiple Answer) Signal transduction involves G protein coupled
receptor systems:
A) biogenic amines
B) peptide hormones
C) eicosanoids
Question # 3 (Multiple Choice) Example(s) of second messenger effect(s):
A) increases in cAMP intracellular concentration
B) changes in intracellular calcium concentration
C) phosphoinositide effects
D) all the above
Question # 4 (Multiple Choice) EC50 mainly reflexs a drug's:
A) maximal effect
B) potency
C) lethality
D) ease of elimination
E) safety
Question # 5 (Multiple Answer) Physiological processes mediated by the
intracellular second messenger, cyclic AMP:
A) carbohydrate breakdown by the liver
B) decreased heart rate
C) increased contractility
D) smooth muscle relaxation
E) triglyceride breakdown
Question # 6 (True/False) Drug effects are thought to be proportional to the number
of occupied receptors
A) true
B) false
Question # 7 (Multiple Choice) Nitric oxide mediates this effect on vascular smooth
muscle:
A) smooth muscle relaxation
B) smooth muscle contraction
C) no effect
Question # 8 (Multiple Choice) Receptors are usually:
A) lipids
B) proteins
C) DNA
Question # 9 (Multiple Choice) Longer-lasting physiological response to drug:
A) increase in heart rate following epinephrine infusion
B) changes in gene product production following corticosteroid injection.
Question # 10 (Multiple Answer) True statement(s) concerning competitive
inhibition:
A) competitive in addition is based on reversible drug/antagonist binding
at receptor sites
B) with competitive inhibition, the dose-effects curve the shifted to the
left
C) with competitive inhibition, maximal drug effect cannot be obtained,
even at high agonist concentrations
D) all the above
Question # 11 (Multiple Answer) Example(s) of endogenous ligands that interact
with membrane-integrated ion channels and affect(s) ion conductance.
A) acetylcholine
B) GABA
C) glutamate
D) aspartate
E) glycine
Question # 12 (Multiple Answer) Example(s) of (a) receptor(s) which is/are enzyme
(s):
A) dihydrofolate reductase
B) acetylcholinesterase
C) monoamine oxidase
Question # 13 (Multiple Choice) Primary mechanism by which cAMP effects are
terminated:
A) enzyme-catalyzed dephosphorylation
B) reuptake into presynaptic nerve terminals
Question # 14 (Multiple Choice) An example of a receptor which is a structural
protein.
A) Na/K ATPase
B) acetylcholinesterase
C) tubulin
D) DNA
E) phospholipase C
Question # 15 (Multiple Choice) An example of an agent that exerts much of its
effects through intracellular receptors that in complex form binds to DNA response
elements:
A) acetylcholine
B) dopamine
C) corticosteroids
D) diltiazem
E) atropine
Question # 16 (Multiple Choice) Factors that may cause variation in drug
responsiveness:
A) changes in the number or function of receptors
B) tachyphylaxis
C) idiosyncratic drug responses
D) hypersensitivity reactions
E) all of the above
Question # 17 (Multiple Answer) Major roles of receptors:
A) determine rate of drug elimination
B) determine drug action selectivity
C) provide a means of blocking drug action as well as mediating drug
action
D) act as drug storage sites
1. CD
2. ABC
3. D
4. B
5. ACDE
6. T
7. A
8. B
9. B
10. A
11. ABCDE
12. ABC
13. A
14. C
15. C
16. E
17. BC
ABCDE
ABC
A
C
C
E
BC