Download Pharm II - 2-22

ANTIPSYCHOTICS
B Y A L A I N A DA R B Y
Which of the following is an example of a negative
symptom of psychosis?
a. Crawling sensation
b.Delusion of grandeur
c. Lack of social interest
d.Waxy flexibility
Which of the following would be an example of
disorganized or catatonic behavior?
a. Tangentiality of speech
b.Inappropriate affect
c. Feeling of persecution
d.Hearing voices
Which of the following is evidence that contradicts
with the dopamine hypothesis?
a. Dopamine underactivity in the prefrontal cortex
causes negative symptoms
b.Time delay in reduction of psychotic symptoms
after treatment
c. Anti-schizophrenic drugs block dopamine
receptors
d.Amphetamine can induce psychosis
Which of the following drugs is used to support the
glutamate hypothesis of schizophrenia?
a. Amphetamine
b.PCP
c. Strychnine
d.Cocaine
Why would targeting mGlu receptors not be a good
method of preventing psychosis?
a. They can modulate glutamate release
b.They can modulate dopamine release
c. There are 8 subtypes of the receptors
d.Agonism can induce seizures
Typical antipsychotics have affinity for all of the
following receptors except…
a. Muscarinic
b.Alpha-adrenergic
c. Histamine
d.Serotonin
e.Dopamine
Which of the following groups of typical
antipsychotics have the highest potency?
a. Phenothiazines with an aliphatic side chain
b.Phenothiazines with a piperidine ring in the side
chain
c. Thioxanthenes
d.Phenothiazines with a piperazine group in the
side chain
Which of the following groups of typical
antipsychotics have the lowest potency?
a. Phenothiazines with an aliphatic side chain
b.Phenothiazines with a piperidine ring in the side
chain
c. Thioxanthenes
d.Phenothiazines with a piperazine group in the
side chain
Which of the following is true of antipsychotics?
a. High potency typicals have a reduced risk of EPS
b.Low potency typicals are less efficacious than
higher potency antipsychotics
c. Atypical antipsychotics have increased affinity for
D2 as compared to typical antipsychotics
d.Increased anticholinergic activity reduces the risk
of EPS
Which of the following atypical antipsychotics has
an active metabolite that is also marketed?
a. Molindone
b.Risperidone
c. Ziprasidone
d.Lurasidone
Which of the following antipsychotics reduces the
incidence of side effects by only partially
antagonizing D2 receptors?
a. Aripiprazole
b.Asenapine
c. Clozapine
d.Lurasidone
Which of the following has affinity for alpha
adrenergic and histamine receptors but low affinity
for muscarinic receptors?
a. Aripiprazole
b.Asenapine
c. Clozapine
d.Lurasidone
Which of the following has a low affinity for
muscarinic and histamine receptors but still
maintains affinity for alpha adrenergic receptors?
a. Iloperidone
b.Resperidone
c. Molindone
d.Lurasidone
Which of the following is considered a low potency
antipsychotic?
a. Fluphenazine
b.Loxapine
c. Thioridazine
d.Pimozide
Which of the following is not an atypical
antipsychotic?
a. Risperidone
b.Olanzepine
c. Loxapine
d.Asenapine
Which receptor do all atypical antipsychotics
target?
a. 5-HT1
b.5-HT2
c. Alpha adrenergic
d.Histamine
e.Muscarinic
Which of the following would have the least side
effects but still has a risk of EPS?
a. Lurasidone
b.Iloperidone
c. Asenapine
d.Rispiridone
The term “neuroleptic syndrome” is used to
describe the therapeutic effects of antipsychotics
that can be seen in animals. Which of the following
is not one of these effects?
a. Supression of spontaneous movements
b.Increased initiative and interest in environment
c. Decreased manifestations of emotion
d.Disappearance of psychotic symptoms
Where are the antipsychotic effects thought to
occur?
a. Cerebral cortex
b.Basal ganglia
c. Limbic system
d.Brainstem
Which of the following increases prolactin
secretion?
a. Lurasidone
b.Iloperidone
c. Asenapine
d.Rispiridone
Which of the following antipsychotics is most likely
to lower seizure thresholds?
a. Olanzapine
b.Rispiridone
c. Ziprasidone
d.Asenapine
What portion of the brain is thought to be
associated with the EPS effects?
a. Cerebral cortex
b.Basal ganglia
c. Limbic system
d.Brainstem
Scott has a family history type II diabetes. With this
in mind, which of the following antipsychotic would
be preferred?
a. Clozapine
b.Rispiridone
c. Thioridazine
d.Olanzepine
Prolonged QT is most likely to be a problem in
which of the following classes of antipsychotics?
a. Low potency typicals
b.Potent typicals
c. Low potency atypicals
d.Potent atypicals
Which of the following is not true of the
pharmacokinetics of antipsychotics?
a. Highly protein bound
b.Accumulates in high blood supply tissues
c. Crosses placental barrier and enters breast milk
d.Good oral absorption
Which of the following is true of antipsychotics?
a. Low therapeutic index
b.Abrupt stoppage causes difficulty sleeping
c. Addicting
d.Most metabolites are active
Which of the following is a neurological side effect
associated with prolonged use of antipsychotics?
a. Acute dystonia
b.Neueroleptic malignant syndrome
c. Tardive dyskinesia
d.Akathesia
Which of the following is benztropine not one of
the primary methods of treatment?
a. Acute dystonia
b.Akathesia
c. Parkinsonian syndrome
d.Neuroleptic malignant syndrome
Which of the following is not a risk of taking
antipsychotics?
a. Type II diabetes
b.Weight gain
c. Jaundice
d.Insomnia
Which of the following is most likely to cause blood
dyscrasis?
a. Clozapine
b.Chlorpromazine
c. Quentiapine
d.Rispiridone
Which of the following is most likely to cause drug
interactions?
a. Thioridazine
b.Haloperidol
c. Pimozide
d.Lurasidone
What would not be a strategy for treating
psychosis?
a. Choose based on side effects
b.Target specific symptoms
c. Use only in schizophrenia
d.Trial and error in drug choice
Which would not be a use of antipsychotics?
a. Major depression
b.Parkinson’s disease
c. Nausea and vomiting
d.Alcoholic hallucinations