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Tramadol - World Health Organization
... Tramadol is contra-indicated, however, in patients with diminished respiratory function. Tramadol is generally considered as a medicinal drug with a low potential for dependence relative to morphine. Nevertheless, tramadol dependence may occur when used for prolonged periods of time (more than sever ...
... Tramadol is contra-indicated, however, in patients with diminished respiratory function. Tramadol is generally considered as a medicinal drug with a low potential for dependence relative to morphine. Nevertheless, tramadol dependence may occur when used for prolonged periods of time (more than sever ...
... preparations. In addition, tramadol and paracetamol were found to reduce the severity of pain and photophobia associated with moderate-to-severe migraine headache [97]. Intra-operative studies showed tramadol did not antagonise the hypnotic effects of volatile inhalational agents (such as isoflurane ...
Investigator`s Brochure - Multidisciplinary Association for
... Risks posed by elevated blood pressure are addressed in clinical trials by excluding people with pre-existing uncontrolled hypertension and by frequently monitoring blood pressure and pulse. Common reactions reported in clinical trials are transient and diminish as drug effects wane during the sessi ...
... Risks posed by elevated blood pressure are addressed in clinical trials by excluding people with pre-existing uncontrolled hypertension and by frequently monitoring blood pressure and pulse. Common reactions reported in clinical trials are transient and diminish as drug effects wane during the sessi ...
MICROMEDEX® Healthcare Series _ Document
... 3) Results of a randomized double-blind study demonstrated that continuation phase treatments of major depressive disorder (MDD) with fluoxetine 20 milligrams (mg) per day (n=21), 60 mg/week (n=28), or placebo (n=21) did not differ in their ability to affect the Hamilton Rating Scale for Depression ...
... 3) Results of a randomized double-blind study demonstrated that continuation phase treatments of major depressive disorder (MDD) with fluoxetine 20 milligrams (mg) per day (n=21), 60 mg/week (n=28), or placebo (n=21) did not differ in their ability to affect the Hamilton Rating Scale for Depression ...
Poisoning and Drug Overdose
... omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each d ...
... omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each d ...
Annex 1 - Emcdda
... injection (intravenous and intramuscular), rectal and smoking. Single use doses for sublingual administration of 25Ig range and may vary from 750 µg to 3750 µg. Although increasing knowledge is emerging about the in vitro and in vivo properties of 25INBOMe, it is difficult to predict with accuracy ...
... injection (intravenous and intramuscular), rectal and smoking. Single use doses for sublingual administration of 25Ig range and may vary from 750 µg to 3750 µg. Although increasing knowledge is emerging about the in vitro and in vivo properties of 25INBOMe, it is difficult to predict with accuracy ...
MICROMEDEX® Healthcare Series - Law Project for Psychiatric
... other psychiatric disorders. Anyone considering the use of paroxetine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Shortterm studies did not show an increase in the risk of suicidality with antidepressants compared to ...
... other psychiatric disorders. Anyone considering the use of paroxetine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Shortterm studies did not show an increase in the risk of suicidality with antidepressants compared to ...
Prescribing Framework for Phenelzine (MAOI) in the treatment of
... enhanced hypotensive effect when MAOIs given with beta-blockers Note: Since systemic absorption may follow topical application of beta-blockers to the eye the possibility of interactions, in particular, with drugs such as verapamil should be borne in mind avoidance of MAOIs advised by manufacturer o ...
... enhanced hypotensive effect when MAOIs given with beta-blockers Note: Since systemic absorption may follow topical application of beta-blockers to the eye the possibility of interactions, in particular, with drugs such as verapamil should be borne in mind avoidance of MAOIs advised by manufacturer o ...
Bipolar Disorders and Lithium: Pharmacokinetics
... anomaly 1/1000 (20X greater risk than the general population). Those who use lithium should receive regular serum level tests and should monitor thyroid and kidney function for abnormalities, as it interferes with the regulation of sodium and water levels in the body, and can cause dehydration. Dehy ...
... anomaly 1/1000 (20X greater risk than the general population). Those who use lithium should receive regular serum level tests and should monitor thyroid and kidney function for abnormalities, as it interferes with the regulation of sodium and water levels in the body, and can cause dehydration. Dehy ...
CITALOPRAM 10 MG, 20 MG AND 40 MG TABLETS PL 36390/0024-6 UKPAR
... combination with monoamine oxidase inhibitor (MAOI), including the selective MAOI selegiline and the reversible MAOI (RIMA), moclobemide and linezolid and in patients who have recently discontinued an SSRI and have been started on a MAOI. Some cases presented with features resembling serotonin syndr ...
... combination with monoamine oxidase inhibitor (MAOI), including the selective MAOI selegiline and the reversible MAOI (RIMA), moclobemide and linezolid and in patients who have recently discontinued an SSRI and have been started on a MAOI. Some cases presented with features resembling serotonin syndr ...
Review articles Treatment of Myoclonus
... Eldridge et al., 1983). Barbiturates have shown their utility by widespread use but are now avoided due to their side effects. Several cases of myoclonus treated with serotonin precursors (e.g. 5-hydroxy-tryptophan) have been reported. However, serotonin precursors are poorly tolerated ; nowadays th ...
... Eldridge et al., 1983). Barbiturates have shown their utility by widespread use but are now avoided due to their side effects. Several cases of myoclonus treated with serotonin precursors (e.g. 5-hydroxy-tryptophan) have been reported. However, serotonin precursors are poorly tolerated ; nowadays th ...
Edi Schwager
... produces increased wakefulness and focus in association with decreased fatigue and appetite. Brand names of medications that contain, or metabolize into, amphetamine include Adderall, Dexedrine, Dextrostat, Desoxyn,[14] ProCentra, and Vyvanse, as well as Benzedrine in the past. The drug is also used ...
... produces increased wakefulness and focus in association with decreased fatigue and appetite. Brand names of medications that contain, or metabolize into, amphetamine include Adderall, Dexedrine, Dextrostat, Desoxyn,[14] ProCentra, and Vyvanse, as well as Benzedrine in the past. The drug is also used ...
Duloxetine Inhibits Effects of MDMA (``Ecstasy``) In Vitro and in
... role of 5-HT and NE in the effects of MDMA in humans. Because the data on monoamine transporter affinity and inhibition have mostly been derived from studies that used rat transporters [17], we investigated the binding and inhibition characteristics of the human monoamine transporters for MDMA, MDA, ...
... role of 5-HT and NE in the effects of MDMA in humans. Because the data on monoamine transporter affinity and inhibition have mostly been derived from studies that used rat transporters [17], we investigated the binding and inhibition characteristics of the human monoamine transporters for MDMA, MDA, ...
Toxicity of Nutmeg (Myristicin): A Review
... presence of other toxins or illnesses. Decontamination measures are usually unnecessary because of the presence of vomiting or delayed contact (ie, > 1 to 2 hours after ingestion) by the health care facility. There are no clinical data to guide the treatment of nutmeg intoxication. The use of standa ...
... presence of other toxins or illnesses. Decontamination measures are usually unnecessary because of the presence of vomiting or delayed contact (ie, > 1 to 2 hours after ingestion) by the health care facility. There are no clinical data to guide the treatment of nutmeg intoxication. The use of standa ...
Sumatriptan Succinate Injection - Pack Insert
... The incidence of adverse reactions in controlled clinical trials was not affected by gender or age of the subjects. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Cluster Headache: In the controlled clinical trials assessing the efficacy of sumatript ...
... The incidence of adverse reactions in controlled clinical trials was not affected by gender or age of the subjects. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Cluster Headache: In the controlled clinical trials assessing the efficacy of sumatript ...
Chronic tolerance to recreational MDMA
... such as caffeine, paracetamol, ephedrine, ketamine, or placebo (Schifano et al., 1998; King, 2000; Spruit, 2001; see also Table 2 in Parrott, 2004a). The third phase was from the late, 1990s to the present, when the proportion of Ecstasy tablets containing MDMA has increased to values around 80–100% ...
... such as caffeine, paracetamol, ephedrine, ketamine, or placebo (Schifano et al., 1998; King, 2000; Spruit, 2001; see also Table 2 in Parrott, 2004a). The third phase was from the late, 1990s to the present, when the proportion of Ecstasy tablets containing MDMA has increased to values around 80–100% ...
MICROMEDEX® Healthcare Series OXCARBAZEPINE
... compared to adults (Prod Info TRILEPTAL(R) oral tablets, oral suspension, 2005) a) Partial seizure, monotherapy 1) 4 to 16 year old, initiation of monotherapy, 8-10 mg/kg/day ORALLY divided doses; may increase dose by 5 mg/kg/day every 3 days to the recommended maintenance dose (Prod Info TRILEPTAL( ...
... compared to adults (Prod Info TRILEPTAL(R) oral tablets, oral suspension, 2005) a) Partial seizure, monotherapy 1) 4 to 16 year old, initiation of monotherapy, 8-10 mg/kg/day ORALLY divided doses; may increase dose by 5 mg/kg/day every 3 days to the recommended maintenance dose (Prod Info TRILEPTAL( ...
Conserved role of dopamine in the modulation of behavior
... to increase cyclic adenosine monophosphate (cAMP) levels, while D2-like receptors (DOP2, DOP3 and DOP4) act both pre- and postsynaptically to reduce cAMP levels.25-27 In addition to D1- and D2-like receptors, some invertebrates also have ionotropic dopamine receptors.28 The competing regulation of c ...
... to increase cyclic adenosine monophosphate (cAMP) levels, while D2-like receptors (DOP2, DOP3 and DOP4) act both pre- and postsynaptically to reduce cAMP levels.25-27 In addition to D1- and D2-like receptors, some invertebrates also have ionotropic dopamine receptors.28 The competing regulation of c ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
... with 5-HT3 receptor antagonist antiemetics, including ZOFRAN and ZOFRAN ODT, when given in combination with other serotonergic and/or neuroleptic drugs. Serotonin syndrome symptoms may include mental status changes (e.g. agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, la ...
... with 5-HT3 receptor antagonist antiemetics, including ZOFRAN and ZOFRAN ODT, when given in combination with other serotonergic and/or neuroleptic drugs. Serotonin syndrome symptoms may include mental status changes (e.g. agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, la ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
... Serotonin syndrome/Neuroleptic Malignant Syndrome: Cases of life-threatening serotonin syndrome or neuroleptic malignant syndrome-like events have been reported with 5-HT3 receptor antagonist antiemetics, including ZOFRAN and ZOFRAN ODT, when given in combination with other serotonergic and/or neuro ...
... Serotonin syndrome/Neuroleptic Malignant Syndrome: Cases of life-threatening serotonin syndrome or neuroleptic malignant syndrome-like events have been reported with 5-HT3 receptor antagonist antiemetics, including ZOFRAN and ZOFRAN ODT, when given in combination with other serotonergic and/or neuro ...
Phenylpropanolamine There are four optical isomers of
... Central nervous system or CNS involvement is present, but the predominant clinical effects are caused by involvement with the sympathetic segment of the peripheral nervous system due to the fact that while ephedrine does cross the blood-brain barrier, it doesn't do this very efficiently (efficient c ...
... Central nervous system or CNS involvement is present, but the predominant clinical effects are caused by involvement with the sympathetic segment of the peripheral nervous system due to the fact that while ephedrine does cross the blood-brain barrier, it doesn't do this very efficiently (efficient c ...
DATA SHEET Tramal Capsules Solution for Injection
... analgesic effect varies considerably between individuals. In one study, the median serum concentration of tramadol required for effective post-operative analgesia was 300 ng/mL, with individual values ranging from 20 to 990 ng/mL. Apart from analgesia, tramadol may produce other symptoms similar to ...
... analgesic effect varies considerably between individuals. In one study, the median serum concentration of tramadol required for effective post-operative analgesia was 300 ng/mL, with individual values ranging from 20 to 990 ng/mL. Apart from analgesia, tramadol may produce other symptoms similar to ...
The Pharmacology of Psychedelic Drugs
... A preliminary discussion of some of the substances which have been exeluded from the present review seems in order. First, according to Osmond, Hoffer and others, adrenochrome and adrenolutln have "psychotomimetic" properties but this has not been generally accepted; ,they are discussed in the secti ...
... A preliminary discussion of some of the substances which have been exeluded from the present review seems in order. First, according to Osmond, Hoffer and others, adrenochrome and adrenolutln have "psychotomimetic" properties but this has not been generally accepted; ,they are discussed in the secti ...
Serotonin syndrome
Serotonin syndrome is a potential symptom of any number of life-threatening drug interactions which may follow therapeutic drug use, combination, overdose of particular drugs, or the recreational use of certain drugs. Serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonin on the CNS and/or peripheral nervous system. For this reason, some experts strongly prefer the terms serotonin toxicity or serotonin toxidrome which more accurately reflect that it is a form of poisoning. Other names include serotonin sickness, serotonin storm, serotonin poisoning, hyperserotonemia, or serotonergic syndrome.Excessive levels of serotonin produce a spectrum of specific symptoms including cognitive, autonomic, and somatic effects. Symptoms may range from barely perceptible to fatal. Numerous drugs and drug combinations have been reported to produce serotonin syndrome, though the exact mechanism is not well understood in many instances.Diagnosis includes observing symptoms and investigating patient history for causal factors (interacting drugs). The syndrome has a characteristic picture but can be mistaken for other illnesses in some people, particularly those with neuroleptic malignant syndrome. No laboratory tests can currently confirm the diagnosis. Hence it is diagnosed based on symptoms, disease course (that is, the progression of the disease) and the exclusion of other possible causes of the presenting symptoms.Treatment consists of discontinuing medications which may contribute and in moderate to severe cases administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation. The high-profile case of Libby Zion, who is generally accepted to have died from serotonin syndrome, resulted in changes to graduate medical education in New York State.