CELEXA PM MKT Control 149419 10Jan2012 En
... When discontinuing treatment, patients should be monitored for symptoms which may be associated with discontinuation. The risk of discontinuation symptoms may be dependent on several factors, including the duration and dose of therapy and the rate of dose reduction. Dizziness, sensory disturbances ( ...
... When discontinuing treatment, patients should be monitored for symptoms which may be associated with discontinuation. The risk of discontinuation symptoms may be dependent on several factors, including the duration and dose of therapy and the rate of dose reduction. Dizziness, sensory disturbances ( ...
Opioid Withdrawal: A New Look At Medication
... due to its effects as an opioid agonist. Dextromethorphan’s binding affinity to mu opioid receptors is 6,000 times less than that of morphine; thus, we would not see much efficacy to diminish withdrawal symptoms due to its mu opioid–receptor activity. Orphenadrine (Norflex, others), a commonly used ...
... due to its effects as an opioid agonist. Dextromethorphan’s binding affinity to mu opioid receptors is 6,000 times less than that of morphine; thus, we would not see much efficacy to diminish withdrawal symptoms due to its mu opioid–receptor activity. Orphenadrine (Norflex, others), a commonly used ...
HUMAN PHARMACOLOGY AYAHUASCA Director de la Tesi:
... Colombia, Daime or Hoasca in Brazil, natema in Ecuador and pinde along the Pacific coast of Colombia. More than 70 indigenous groups are known to employ ayahuasca, for which 42 different vernacular names have been reported (Luna, 1986). The use of this pan-Amazonian psychotropic beverage appears to ...
... Colombia, Daime or Hoasca in Brazil, natema in Ecuador and pinde along the Pacific coast of Colombia. More than 70 indigenous groups are known to employ ayahuasca, for which 42 different vernacular names have been reported (Luna, 1986). The use of this pan-Amazonian psychotropic beverage appears to ...
Norepinephrine - Meridian Kinesiology
... Persons afflicted with Alzheimer's Disease usually have insufficient Norepinephrine in their Brains [scientific research - humans]. NE depletion can cause Apathy. NE suppresses Appetite. NE stimulates Beta-1 Adrenergic Receptors. NE stimulates Beta-2 Adrenergic Receptors (although NE has less affini ...
... Persons afflicted with Alzheimer's Disease usually have insufficient Norepinephrine in their Brains [scientific research - humans]. NE depletion can cause Apathy. NE suppresses Appetite. NE stimulates Beta-1 Adrenergic Receptors. NE stimulates Beta-2 Adrenergic Receptors (although NE has less affini ...
Deadly pediatric poisons: nine common agents that kill at low doses
... glucagon has been recommended in cases of significant CCA toxicity [24,36– 38]. Because glucagon acts by activating the intracellular second messenger cascade downstream from the b-receptor, it offers little obvious advantage beyond the use of traditional pressor agents in CCA toxicity [39]. Nonethele ...
... glucagon has been recommended in cases of significant CCA toxicity [24,36– 38]. Because glucagon acts by activating the intracellular second messenger cascade downstream from the b-receptor, it offers little obvious advantage beyond the use of traditional pressor agents in CCA toxicity [39]. Nonethele ...
Dextromethorphan abuse: Clinical effects
... inexpensive and easily accessible over-the-counter (OTC) medication intended for use as an antitussant— has in recent years been increasingly used for illicit purposes, particularly by adolescents. Because DM is a common ingredient in many OTC cough and cold medications, many abusers consider DM mis ...
... inexpensive and easily accessible over-the-counter (OTC) medication intended for use as an antitussant— has in recent years been increasingly used for illicit purposes, particularly by adolescents. Because DM is a common ingredient in many OTC cough and cold medications, many abusers consider DM mis ...
NIDA Research Report - MDMA
... occasions, this has led to severe medical consequences, including death. Also, MDMA causes the release of another neurotransmitter, norepinephrine, which is likely the cause of the increase in heart rate and blood pressure that often accompanies MDMA use. ...
... occasions, this has led to severe medical consequences, including death. Also, MDMA causes the release of another neurotransmitter, norepinephrine, which is likely the cause of the increase in heart rate and blood pressure that often accompanies MDMA use. ...
Serotonin-mediated central fatigue underlies increased endurance
... agonists and transport inhibitors during exercise is well established [3, 4]. The predictive factor in 5-HT-generated central fatigue may not be 5-HT concentration alone, but the ratio of 5-HT:DA in such brain regions as the striatum [2]. The relevance of that ratio may be because 5-HT appears to in ...
... agonists and transport inhibitors during exercise is well established [3, 4]. The predictive factor in 5-HT-generated central fatigue may not be 5-HT concentration alone, but the ratio of 5-HT:DA in such brain regions as the striatum [2]. The relevance of that ratio may be because 5-HT appears to in ...
Tramadol - Medsafe
... These reactions often occur following the first dose. Other reported reactions include pruritus, hives, bronchospasm and angioedema. Serotonin syndrome The presence of another drug that increases serotonin by any mechanism should alert the treating physician to the possibility of an interaction. In ...
... These reactions often occur following the first dose. Other reported reactions include pruritus, hives, bronchospasm and angioedema. Serotonin syndrome The presence of another drug that increases serotonin by any mechanism should alert the treating physician to the possibility of an interaction. In ...
NIDA Research Report - MDMA
... occasions, this has led to severe medical consequences, including death. Also, MDMA causes the release of another neurotransmitter, norepinephrine, which is likely the cause of the increase in heart rate and blood pressure that often accompanies MDMA use. ...
... occasions, this has led to severe medical consequences, including death. Also, MDMA causes the release of another neurotransmitter, norepinephrine, which is likely the cause of the increase in heart rate and blood pressure that often accompanies MDMA use. ...
Biochemical Toxicity Induced By Tramadol
... and some metabolic parameters were studied in male rats. Methods: Rats were divided into three groups. Group one received vehicle (saline), group two and three received oral doses of tramadol equal to 40 mg and 80 mg / kg body weight / day respectively for a month followed by 10 days recovery period ...
... and some metabolic parameters were studied in male rats. Methods: Rats were divided into three groups. Group one received vehicle (saline), group two and three received oral doses of tramadol equal to 40 mg and 80 mg / kg body weight / day respectively for a month followed by 10 days recovery period ...
Samanta Yubero Lahoz MDMA PHARMACOLOGY IN HUMANS AND SEROTONERGIC EFFECTS
... 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most abused recreational drugs in the world. It has been extensively reported that this drug inhibits its own metabolism by inhibiting a polymorphic liver enzyme, CYP2D6, which is responsible for the clearance of one quarter of drugs us ...
... 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most abused recreational drugs in the world. It has been extensively reported that this drug inhibits its own metabolism by inhibiting a polymorphic liver enzyme, CYP2D6, which is responsible for the clearance of one quarter of drugs us ...
Product Monograph Template - Standard
... Monoamine Oxidase Inhibitors: In patients receiving serotonin reuptake inhibitors (SSRIs) in combination with a MAO inhibitor, there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital s ...
... Monoamine Oxidase Inhibitors: In patients receiving serotonin reuptake inhibitors (SSRIs) in combination with a MAO inhibitor, there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital s ...
Expert peer review No.1 Agenda item 6.1: Tramadol
... b. Risks to individual and society because of misuse ...
... b. Risks to individual and society because of misuse ...
Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures Zheng Zhou
... important for binding to LeuT (Fig. 1). The observation that halogensubstituted phenyl rings and particularly the halogen atoms themselves—the most important determinants for SSRI specificity—bind at the same position in LeuT (Fig. 2) immediately suggests that in the human SERT these SSRIs may also ...
... important for binding to LeuT (Fig. 1). The observation that halogensubstituted phenyl rings and particularly the halogen atoms themselves—the most important determinants for SSRI specificity—bind at the same position in LeuT (Fig. 2) immediately suggests that in the human SERT these SSRIs may also ...
Paxil - GlaxoSmithKline
... Monoamine Oxidase Inhibitors: In patients receiving serotonin reuptake inhibitors (SSRIs) in combination with a MAO inhibitor, there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital s ...
... Monoamine Oxidase Inhibitors: In patients receiving serotonin reuptake inhibitors (SSRIs) in combination with a MAO inhibitor, there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital s ...
PAXIL PRODUCT MONOGRAPH
... Monoamine Oxidase Inhibitors: In patients receiving serotonin reuptake inhibitors (SSRIs) in combination with a MAO inhibitor, there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital s ...
... Monoamine Oxidase Inhibitors: In patients receiving serotonin reuptake inhibitors (SSRIs) in combination with a MAO inhibitor, there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital s ...
Reserpine ameliorates Aβ toxicity in the Alzheimer`s disease model
... diseases (Cohen et al., 2006; Steinkraus et al., 2008) and could be used as a drug evaluation model as shown for Ginkgo biloba extract (Wu et al., 2006). In addition, neuronal expression of Ab in C. elegans causes hypersensitivity to exogenous serotonin. This hypersensitivity could be reversed by Gi ...
... diseases (Cohen et al., 2006; Steinkraus et al., 2008) and could be used as a drug evaluation model as shown for Ginkgo biloba extract (Wu et al., 2006). In addition, neuronal expression of Ab in C. elegans causes hypersensitivity to exogenous serotonin. This hypersensitivity could be reversed by Gi ...
Analgesia en pacientes con ERC
... CYP2D6 inhibitors: May decrease the effects of codeine. Example inhibitors include chlorpromazine, delavirdine, fluoxetine, miconazole, paroxetine, pergolide, quinidine, quinine, ritonavir, and ropinirole. Decreased effect with cigarette smoking Increased toxicity: CNS depressants, phenothiazines, T ...
... CYP2D6 inhibitors: May decrease the effects of codeine. Example inhibitors include chlorpromazine, delavirdine, fluoxetine, miconazole, paroxetine, pergolide, quinidine, quinine, ritonavir, and ropinirole. Decreased effect with cigarette smoking Increased toxicity: CNS depressants, phenothiazines, T ...
lustral - Pharmaline
... Serotonin Syndrome (SS) or Neuroleptic Malignant Syndrome (NMS) The development of potentially life-threatening syndromes like serotonin syndrome (SS) or Neuroleptic Malignant Syndrome (NMS) has been reported with SSRIs, including treatment with sertraline. The risk of SS or NMS with SSRIs is increa ...
... Serotonin Syndrome (SS) or Neuroleptic Malignant Syndrome (NMS) The development of potentially life-threatening syndromes like serotonin syndrome (SS) or Neuroleptic Malignant Syndrome (NMS) has been reported with SSRIs, including treatment with sertraline. The risk of SS or NMS with SSRIs is increa ...
Memorandum 0429 '03 JAN 27 P2:21
... This is in response to your submission of a new dietary ingredient notification, dated July 21, 2002, to the Food and Drug Administration (FDA) pursuant to 21 U. S.C. 350b(a)(2) and 21 Code of Federal Regulations (CFR) Part 190.6. FDA received your notification on July 26, 2002, of your intent to ma ...
... This is in response to your submission of a new dietary ingredient notification, dated July 21, 2002, to the Food and Drug Administration (FDA) pursuant to 21 U. S.C. 350b(a)(2) and 21 Code of Federal Regulations (CFR) Part 190.6. FDA received your notification on July 26, 2002, of your intent to ma ...
Herb-medicine interactions: St John`s wort
... authorisation. They are supplied as herbal remedies exempt from licensing under the Medicines Act, and no medical claims are permitted. Evidence from controlled clinical trials suggests that St John’s wort extracts are effective in the treatment of mild to moderate depression, and may be as effectiv ...
... authorisation. They are supplied as herbal remedies exempt from licensing under the Medicines Act, and no medical claims are permitted. Evidence from controlled clinical trials suggests that St John’s wort extracts are effective in the treatment of mild to moderate depression, and may be as effectiv ...
Hyperforin as a natural antidepressant: an overview
... Warfarin and related medicines used to thin the blood (known as anticoagulants)41 When combined with certain antidepressants, St. John’s wort also may increase side effects such as nausea, anxiety, headache, and confusion. CONCLUSION: Now a days herbal drugs are too in demand and interaction of herb ...
... Warfarin and related medicines used to thin the blood (known as anticoagulants)41 When combined with certain antidepressants, St. John’s wort also may increase side effects such as nausea, anxiety, headache, and confusion. CONCLUSION: Now a days herbal drugs are too in demand and interaction of herb ...
Influence of CYP2D6 genotype on the
... resulting in high plasma drug concentrations, lack of therapeutic response and/or an increased risk for side-effects. Another risk group is individuals who have a substantially increased metabolism, e.g. due to more than two functional copies of the CYP2D6 gene, which can lead to therapeutic failure ...
... resulting in high plasma drug concentrations, lack of therapeutic response and/or an increased risk for side-effects. Another risk group is individuals who have a substantially increased metabolism, e.g. due to more than two functional copies of the CYP2D6 gene, which can lead to therapeutic failure ...
Serotonin syndrome
Serotonin syndrome is a potential symptom of any number of life-threatening drug interactions which may follow therapeutic drug use, combination, overdose of particular drugs, or the recreational use of certain drugs. Serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonin on the CNS and/or peripheral nervous system. For this reason, some experts strongly prefer the terms serotonin toxicity or serotonin toxidrome which more accurately reflect that it is a form of poisoning. Other names include serotonin sickness, serotonin storm, serotonin poisoning, hyperserotonemia, or serotonergic syndrome.Excessive levels of serotonin produce a spectrum of specific symptoms including cognitive, autonomic, and somatic effects. Symptoms may range from barely perceptible to fatal. Numerous drugs and drug combinations have been reported to produce serotonin syndrome, though the exact mechanism is not well understood in many instances.Diagnosis includes observing symptoms and investigating patient history for causal factors (interacting drugs). The syndrome has a characteristic picture but can be mistaken for other illnesses in some people, particularly those with neuroleptic malignant syndrome. No laboratory tests can currently confirm the diagnosis. Hence it is diagnosed based on symptoms, disease course (that is, the progression of the disease) and the exclusion of other possible causes of the presenting symptoms.Treatment consists of discontinuing medications which may contribute and in moderate to severe cases administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation. The high-profile case of Libby Zion, who is generally accepted to have died from serotonin syndrome, resulted in changes to graduate medical education in New York State.