Nefazodone in the rat: mimicry and antagonism of [À]-DOM
... altered, relative to dose, by pretreatment with the monoamine reuptake inhibitor, nefazodone. Similar to ( ± ) fluoxetine, fluvoxamine, and venlafaxine (Winter et al., 1999a), the enhancement of [ ]-DOM-induced stimulus control occurs in the presence of significant partial substitution by nefazodone ...
... altered, relative to dose, by pretreatment with the monoamine reuptake inhibitor, nefazodone. Similar to ( ± ) fluoxetine, fluvoxamine, and venlafaxine (Winter et al., 1999a), the enhancement of [ ]-DOM-induced stimulus control occurs in the presence of significant partial substitution by nefazodone ...
SNRIs: an approach - Psychopharmacology Institute
... Remeron (Mirtazapine) [Prescribing Information] NJ: Merck & Co., Inc. Accessed June 2014 RemeronSolTab (Mirtazapine) [Prescribing Information] NJ: Merck & Co., Inc. Accessed June 2014 ...
... Remeron (Mirtazapine) [Prescribing Information] NJ: Merck & Co., Inc. Accessed June 2014 RemeronSolTab (Mirtazapine) [Prescribing Information] NJ: Merck & Co., Inc. Accessed June 2014 ...
Pregnancy
... appropriate evaluation should be carried out. There have been rare post-marketing reports describing patients with serotonin syndrome (including altered mental status, autonomic instability and neuromuscular abnormalities) following the use of a selective serotonin reuptake inhibitor (SSRI) and suma ...
... appropriate evaluation should be carried out. There have been rare post-marketing reports describing patients with serotonin syndrome (including altered mental status, autonomic instability and neuromuscular abnormalities) following the use of a selective serotonin reuptake inhibitor (SSRI) and suma ...
“Robo-Tripping”: Dextromethorphan Abuse and its Anesthetic
... similar to those described with other NMDA receptor antagonists. Thus, it appears likely that the anesthetic implications of acute dextromethorphan abuse may be quite similar those associated with abuse of ketamine or phencyclidine, but at present, no data have been published to verify this contenti ...
... similar to those described with other NMDA receptor antagonists. Thus, it appears likely that the anesthetic implications of acute dextromethorphan abuse may be quite similar those associated with abuse of ketamine or phencyclidine, but at present, no data have been published to verify this contenti ...
Treatment of patients with UA-hard problem, because it should be
... lateral and lower parts of the abdominal wall, in the hips, lower back, that is, in areas of maximum accumulation of edema fluid with variable stretching of the skin, breaking its elastic membrane, the formation of scar connective tissue. At the height of the National Assembly, most patients have tr ...
... lateral and lower parts of the abdominal wall, in the hips, lower back, that is, in areas of maximum accumulation of edema fluid with variable stretching of the skin, breaking its elastic membrane, the formation of scar connective tissue. At the height of the National Assembly, most patients have tr ...
Zolmitriptan and human aggression: interaction
... behavior and 5-HT receptor sub-types. Zolmitriptan, one of numerous triptans, is indicated for migraine relief by acting as an agonist at the 5-HT 1B/D receptor, causing intracranial blood vessels to contract and reduce pressure (Peterlin and Rapoport 2007). Secondgeneration triptans, such as zolmit ...
... behavior and 5-HT receptor sub-types. Zolmitriptan, one of numerous triptans, is indicated for migraine relief by acting as an agonist at the 5-HT 1B/D receptor, causing intracranial blood vessels to contract and reduce pressure (Peterlin and Rapoport 2007). Secondgeneration triptans, such as zolmit ...
Vomiting
... behavioral changes, especially during rapid intravenous administration or if given at high doses. Metoclopramide controls peripherally induced and humorally mediated vomiting due to numerous conditions, but it should be avoided if gastrointestinal obstruction is suspected because its prokinetic prop ...
... behavioral changes, especially during rapid intravenous administration or if given at high doses. Metoclopramide controls peripherally induced and humorally mediated vomiting due to numerous conditions, but it should be avoided if gastrointestinal obstruction is suspected because its prokinetic prop ...
Ibogaine
... Ibogaine treatment might result in the “resetting”or “normalization”of neuro-adaptations related to drug sensitization or tolerance. Ibogaine pretreatment blocked the expression of sensitization-induced increases in the release of dopamine in the Nac shell. Opposition or reversal of effects on secon ...
... Ibogaine treatment might result in the “resetting”or “normalization”of neuro-adaptations related to drug sensitization or tolerance. Ibogaine pretreatment blocked the expression of sensitization-induced increases in the release of dopamine in the Nac shell. Opposition or reversal of effects on secon ...
Selective Suppression of Cocaine- versus Food
... choice and toward food choice (Negus, 2003). In a doubleblind, placebo-controlled clinical study, amphetamine maintenance dose-dependently reduced cocaine use (Grabowski et al., 2001), and similar findings have been reported in other clinical studies (for review, see Grabowski et al., 2004). Other a ...
... choice and toward food choice (Negus, 2003). In a doubleblind, placebo-controlled clinical study, amphetamine maintenance dose-dependently reduced cocaine use (Grabowski et al., 2001), and similar findings have been reported in other clinical studies (for review, see Grabowski et al., 2004). Other a ...
Serotonin Transporter Occupancy of Five Selective Serotonin
... cingulate, and cerebellum to measure occupancy has been described previously (2, 7, 31, 32). For the midbrain region of interest, the border of the midbrain was drawn in the two planes superior to the pons. In two subjects, only one plane of the midbrain was used, as the pons and midbrain structures ...
... cingulate, and cerebellum to measure occupancy has been described previously (2, 7, 31, 32). For the midbrain region of interest, the border of the midbrain was drawn in the two planes superior to the pons. In two subjects, only one plane of the midbrain was used, as the pons and midbrain structures ...
EU Core Safety Profile
... sertraline. In many cases, hyponatraemia appears to be the result of a syndrome of inappropriate antidiuretic hormone secretion (SIADH). Cases of serum sodium levels lower than 110 mmol/l have been reported. Elderly patients may be at greater risk of developing hyponatraemia with SSRIs and SNRIs. Al ...
... sertraline. In many cases, hyponatraemia appears to be the result of a syndrome of inappropriate antidiuretic hormone secretion (SIADH). Cases of serum sodium levels lower than 110 mmol/l have been reported. Elderly patients may be at greater risk of developing hyponatraemia with SSRIs and SNRIs. Al ...
xtram plus
... be exceeded. In order to avoid inadvertent overdose, patients should be advised not to exceed the recommended dose and not to use any other paracetamol (including over the counter) or tramadol hydrochloride containing products concurrently without the advice of a physician. In severe renal insuffici ...
... be exceeded. In order to avoid inadvertent overdose, patients should be advised not to exceed the recommended dose and not to use any other paracetamol (including over the counter) or tramadol hydrochloride containing products concurrently without the advice of a physician. In severe renal insuffici ...
O R I G I N A L A R T I C L E
... pharmacologically inactive (Da Prada et al. 1989; Baker et al. 1999). MAO inhibitors were developed as antidepressants but many drugs, including the oxazolidinone antibacterial agents, share similar molecular properties and have MAO inhibitory activity. These compounds were of interest as potential ...
... pharmacologically inactive (Da Prada et al. 1989; Baker et al. 1999). MAO inhibitors were developed as antidepressants but many drugs, including the oxazolidinone antibacterial agents, share similar molecular properties and have MAO inhibitory activity. These compounds were of interest as potential ...
ULTRACET C IV
... with the use of tramadol products, including ULTRACET, particularly with concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs, and triptans, with drugs which impair metabolism of serotonin (including MAOIs), and with drugs which impair metabolism of tramadol (CYP2D6 and CYP3A4 in ...
... with the use of tramadol products, including ULTRACET, particularly with concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs, and triptans, with drugs which impair metabolism of serotonin (including MAOIs), and with drugs which impair metabolism of tramadol (CYP2D6 and CYP3A4 in ...
Appetite Suppressor Induced Psychosis
... and her boss’s boyfriend were watching her using a concealed microphone and video camera. She believed that they were watching her because she knew too much about their private issues. She had not taken her appetite suppressant since August 16, 5 days before admission. On admission, her scores on th ...
... and her boss’s boyfriend were watching her using a concealed microphone and video camera. She believed that they were watching her because she knew too much about their private issues. She had not taken her appetite suppressant since August 16, 5 days before admission. On admission, her scores on th ...
Fluoxetine effect on gestation and fetal development
... cardiovascular anomalies and first-trimester exposure to fluoxetine [12]. Preclinical studies suggest that the inclusion of fluoxetine in pregnancy category C is justified and the appropriateness of its administration in pregnancy is still an unresolved issue. Therefore, for complete understanding f ...
... cardiovascular anomalies and first-trimester exposure to fluoxetine [12]. Preclinical studies suggest that the inclusion of fluoxetine in pregnancy category C is justified and the appropriateness of its administration in pregnancy is still an unresolved issue. Therefore, for complete understanding f ...
Psilocybin - TU Darmstadt Chemie
... significant first pass effect can be assumed. Four metabolites have been identified, see figure below. A shorter half-life after i.v. administration (mean 74,1+/- 19,6 min.) is reported compared to oral administration (163 +/- 64 min.). Maximum plasma concentrations were observed after 80 minutes. T ...
... significant first pass effect can be assumed. Four metabolites have been identified, see figure below. A shorter half-life after i.v. administration (mean 74,1+/- 19,6 min.) is reported compared to oral administration (163 +/- 64 min.). Maximum plasma concentrations were observed after 80 minutes. T ...
Piriformis syndrome is a neuromuscular condition that remains
... sciatic nerve pierces or splits the piriformis muscle, which can predispose these individuals to piriformis syndrome. (Figure 1) Clinical Presentation History and physical examination are critical to identify piriformis syndrome. The most common presenting symptom is increasing pain after sitting fo ...
... sciatic nerve pierces or splits the piriformis muscle, which can predispose these individuals to piriformis syndrome. (Figure 1) Clinical Presentation History and physical examination are critical to identify piriformis syndrome. The most common presenting symptom is increasing pain after sitting fo ...
Fluoxetine-AFT Presentation Fluoxetine hydrochloride equivalent to Fluoxetine 20mg/5mL Oral Liquid
... selective serotonin reuptake inhibitors and herbal preparations containing St John’s Wort (Hypericum perforatum) are used together. ...
... selective serotonin reuptake inhibitors and herbal preparations containing St John’s Wort (Hypericum perforatum) are used together. ...
Fluoxetin Mylan dispersible tablet ENG SmPC
... Irreversible non-selective monoamine oxidase inhibitors (e.g. iproniazid): Some cases of serious and sometimes fatal reactions have been reported in patients receiving an SSRI in combination with an irreversible, non-selective monoamine oxidase inhibitor (MAOI). These cases presented with features ...
... Irreversible non-selective monoamine oxidase inhibitors (e.g. iproniazid): Some cases of serious and sometimes fatal reactions have been reported in patients receiving an SSRI in combination with an irreversible, non-selective monoamine oxidase inhibitor (MAOI). These cases presented with features ...
Exercise, Ethanol, and Disease
... users about 650,000 are heavy abusers, about a 20% incidence (2x the “normal” incidence of compulsive abuse with most other drugs). Of these abusers, the majority smoke the drug and usually progressed from snorting – to IV – to smoking. By looking at how the drug affects CNS activity one may determi ...
... users about 650,000 are heavy abusers, about a 20% incidence (2x the “normal” incidence of compulsive abuse with most other drugs). Of these abusers, the majority smoke the drug and usually progressed from snorting – to IV – to smoking. By looking at how the drug affects CNS activity one may determi ...
NEW ZEALAND DATA SHEET PROVEBLUE
... Methylene blue may interact with any drug that acts as a serotonin reuptake inhibitor (SRI) including, amongst others, selective serotonin reuptake inhibits (SSRIs) such as fluvoxamine, fluoxetin, paroxetine, sertraline, escitalopram and citalopram, and serotonin and noradrenaline reuptake inhibitor ...
... Methylene blue may interact with any drug that acts as a serotonin reuptake inhibitor (SRI) including, amongst others, selective serotonin reuptake inhibits (SSRIs) such as fluvoxamine, fluoxetin, paroxetine, sertraline, escitalopram and citalopram, and serotonin and noradrenaline reuptake inhibitor ...
Managing weight gain as a side effect of
... lb after 6 months of therapy. Whether or not these findings can be generalized to community patients is unclear. ■ SELECTIVE SEROTONIN REUPTAKE INHIBITORS Weight gain is less likely with SSRIs when they are used for 6 months or less. There are diverse opinions about whether increases in body weight ...
... lb after 6 months of therapy. Whether or not these findings can be generalized to community patients is unclear. ■ SELECTIVE SEROTONIN REUPTAKE INHIBITORS Weight gain is less likely with SSRIs when they are used for 6 months or less. There are diverse opinions about whether increases in body weight ...
Extracellular serotonin in the lateral hypothalamic area is increased
... 1989; Aoyagi et al., 1992). These findings suggest that LHA 5-HT can inhibit at least one motivated behavior; whether others, such as copulation, may be influenced similarly remains to be tested. Preliminary in vivo experiments in this laboratory showed that 5-HT release increases in the anterior LH ...
... 1989; Aoyagi et al., 1992). These findings suggest that LHA 5-HT can inhibit at least one motivated behavior; whether others, such as copulation, may be influenced similarly remains to be tested. Preliminary in vivo experiments in this laboratory showed that 5-HT release increases in the anterior LH ...
The substituted amphetamines 3,4
... of two drugs releases more 5-HT than does either drug alone at an equivalent concentration. We hypothesized that if these drugs caused release via different mechanisms, then a combination of two of them may cause a significant higher percentage of release than each one alone at an equivalent concent ...
... of two drugs releases more 5-HT than does either drug alone at an equivalent concentration. We hypothesized that if these drugs caused release via different mechanisms, then a combination of two of them may cause a significant higher percentage of release than each one alone at an equivalent concent ...
Serotonin syndrome
Serotonin syndrome is a potential symptom of any number of life-threatening drug interactions which may follow therapeutic drug use, combination, overdose of particular drugs, or the recreational use of certain drugs. Serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonin on the CNS and/or peripheral nervous system. For this reason, some experts strongly prefer the terms serotonin toxicity or serotonin toxidrome which more accurately reflect that it is a form of poisoning. Other names include serotonin sickness, serotonin storm, serotonin poisoning, hyperserotonemia, or serotonergic syndrome.Excessive levels of serotonin produce a spectrum of specific symptoms including cognitive, autonomic, and somatic effects. Symptoms may range from barely perceptible to fatal. Numerous drugs and drug combinations have been reported to produce serotonin syndrome, though the exact mechanism is not well understood in many instances.Diagnosis includes observing symptoms and investigating patient history for causal factors (interacting drugs). The syndrome has a characteristic picture but can be mistaken for other illnesses in some people, particularly those with neuroleptic malignant syndrome. No laboratory tests can currently confirm the diagnosis. Hence it is diagnosed based on symptoms, disease course (that is, the progression of the disease) and the exclusion of other possible causes of the presenting symptoms.Treatment consists of discontinuing medications which may contribute and in moderate to severe cases administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation. The high-profile case of Libby Zion, who is generally accepted to have died from serotonin syndrome, resulted in changes to graduate medical education in New York State.