1 SUMMARY OF PRODUCT CHARACTERISTICS 1 - CBG-MEB
... On rare occasions development of a serotonin syndrome or neuroleptic malignant syndromelike events have been reported in association with treatment of fluoxetine, particularly when given in combination with other serotonergic (among others L-tryptophan) and/or neuroleptic drugs (see section 4.5). As ...
... On rare occasions development of a serotonin syndrome or neuroleptic malignant syndromelike events have been reported in association with treatment of fluoxetine, particularly when given in combination with other serotonergic (among others L-tryptophan) and/or neuroleptic drugs (see section 4.5). As ...
General - EmergencyPedia
... Lung effects more related to FiO2 than PiO2 – no – more related to pressure than fraction??? ...
... Lung effects more related to FiO2 than PiO2 – no – more related to pressure than fraction??? ...
Dangers of Ecstasy
... no MDMA at all, and five other active substances were identified.2 Seven deaths in South Australia in the late 1990s were found to be related to paramethoxyamphetamine (PMA, known as 'death'), the victims having taken what they thought was ecstasy.3 Ecstasy is usually taken in the form of a tablet o ...
... no MDMA at all, and five other active substances were identified.2 Seven deaths in South Australia in the late 1990s were found to be related to paramethoxyamphetamine (PMA, known as 'death'), the victims having taken what they thought was ecstasy.3 Ecstasy is usually taken in the form of a tablet o ...
SUBLIMAZE Injection
... Caution is advised when SUBLIMAZE is coadministered with drugs that affect the serotonergic neurotransmitter systems. The development of a potentially life-threatening serotonin syndrome may occur with the concomitant use of serotonergic drugs such as Selective Serotonin Re-uptake Inhibitors (SSRIs) ...
... Caution is advised when SUBLIMAZE is coadministered with drugs that affect the serotonergic neurotransmitter systems. The development of a potentially life-threatening serotonin syndrome may occur with the concomitant use of serotonergic drugs such as Selective Serotonin Re-uptake Inhibitors (SSRIs) ...
Neurochemical Neutralization of Methamphetamine With High
... mesolimbic DA, but to also block their cardiovascular and neurotoxic effects. As noted in the Introduction, we anticipate that a high-affinity slowly dissociating agent at all three transporters, which would also be amenable to formulation as a long-acting depot medication, would not only neutralize ...
... mesolimbic DA, but to also block their cardiovascular and neurotoxic effects. As noted in the Introduction, we anticipate that a high-affinity slowly dissociating agent at all three transporters, which would also be amenable to formulation as a long-acting depot medication, would not only neutralize ...
Fluoxetine Accord capsule, hard ENG SmPC
... long QT syndrome, a family history of QT prolongation or other clinical conditions that predispose to arrhythmias (e.g., hypokalemia, hypomagnesemia, bradycardia, acute myocardial infarction or uncompensated heart failure) or increased exposure to fluoxetine (e.g., hepatic impairment), or concomitan ...
... long QT syndrome, a family history of QT prolongation or other clinical conditions that predispose to arrhythmias (e.g., hypokalemia, hypomagnesemia, bradycardia, acute myocardial infarction or uncompensated heart failure) or increased exposure to fluoxetine (e.g., hepatic impairment), or concomitan ...
Effect of serotonin depletion on cortical spreading depression
... Background: The cortical spreading depression (CSD) is a phenomenon associated with several pathological conditions including migraine. It can induce alterations in both neural and vascular compartments. Serotonin (5-HT) depletion is known as a condition involved in migraine pathophysiology. The hyp ...
... Background: The cortical spreading depression (CSD) is a phenomenon associated with several pathological conditions including migraine. It can induce alterations in both neural and vascular compartments. Serotonin (5-HT) depletion is known as a condition involved in migraine pathophysiology. The hyp ...
Anadol - Square Pharmaceuticals Ltd.
... Tramadol is contraindicated in persons having hypersensitivity to this drug. It is also contraindicated in acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic drugs. Drug Interaction In general, physician need not be concerned about drugs interacting with ...
... Tramadol is contraindicated in persons having hypersensitivity to this drug. It is also contraindicated in acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic drugs. Drug Interaction In general, physician need not be concerned about drugs interacting with ...
Stahl_3rd_ch04_Part2..
... that causes no change in signal transduction - including no change in whatever amount of any "constitutive" activity that may have been present in the absence of agonist (compare Figure 4-22 with Figure 4-24). Thus, true antagonists are "neutral," and since they have no actions of their own, they ar ...
... that causes no change in signal transduction - including no change in whatever amount of any "constitutive" activity that may have been present in the absence of agonist (compare Figure 4-22 with Figure 4-24). Thus, true antagonists are "neutral," and since they have no actions of their own, they ar ...
Vol 10, Issue 2 - Utah Poison Control Center
... abnormalities. Medications affect serotonergic activity by increasing production, release, or receptor stimulation, or by inhibition of metabolism or reuptake. Serotonin syndrome often occurs after the recent change in medication or addition of a new medication that affects the serotonergic activi ...
... abnormalities. Medications affect serotonergic activity by increasing production, release, or receptor stimulation, or by inhibition of metabolism or reuptake. Serotonin syndrome often occurs after the recent change in medication or addition of a new medication that affects the serotonergic activi ...
Tourette*s syndrome
... • have had tics for at least a year. The tics can occur many times a day (usually in bouts) nearly every day, or off and on. • have tics that begin before he or she is 18 years of age. • have symptoms that are not due to taking medicine or other drugs or due to having another medical condition (for ...
... • have had tics for at least a year. The tics can occur many times a day (usually in bouts) nearly every day, or off and on. • have tics that begin before he or she is 18 years of age. • have symptoms that are not due to taking medicine or other drugs or due to having another medical condition (for ...
Fatal intoxication due to tramadol alone Case report and review of
... LSD in urine and benzodiazepines in blood. Presumptive colour tests (according to the manufacturer’s specifications) were used to detect salicylates, paracetamol, phenothiazines and imipramines. UV spectrophotometry was used for quantification of carbon monoxide and cyanide in blood. Thin layer chro ...
... LSD in urine and benzodiazepines in blood. Presumptive colour tests (according to the manufacturer’s specifications) were used to detect salicylates, paracetamol, phenothiazines and imipramines. UV spectrophotometry was used for quantification of carbon monoxide and cyanide in blood. Thin layer chro ...
Ro 11-2465 (cyan-imipramine), citalopram and their N
... should be regarded as an important argument for the NAergic hylW_thcsis of depression (Schildkraut 1t)65; Schildkraut and Kety 1967) rather than an argument for the 5-HT-ergicone. Literature data show that dcsmcthylcitalopram (D('IT), which is the main metabolite of C'lT in rats, mice, monkeys and i ...
... should be regarded as an important argument for the NAergic hylW_thcsis of depression (Schildkraut 1t)65; Schildkraut and Kety 1967) rather than an argument for the 5-HT-ergicone. Literature data show that dcsmcthylcitalopram (D('IT), which is the main metabolite of C'lT in rats, mice, monkeys and i ...
How do you switch between tricyclic, SSRI and related
... used at the right dose for an appropriate duration of time, or the presence of intolerable side effects. When switching between antidepressants there is the potential for interaction between the two agents and/or for the patient to experience drug discontinuation symptoms from withdrawal of the firs ...
... used at the right dose for an appropriate duration of time, or the presence of intolerable side effects. When switching between antidepressants there is the potential for interaction between the two agents and/or for the patient to experience drug discontinuation symptoms from withdrawal of the firs ...
Annex I : CSP – final clean version
... treatment and within 7 days following discontinuation of study drug. More patients in the linezolid arm acquired Gram negative pathogens during the study and died from infection caused by Gram negative pathogens and polymicrobial infections. Therefore, in complicated skin and soft tissue infections ...
... treatment and within 7 days following discontinuation of study drug. More patients in the linezolid arm acquired Gram negative pathogens during the study and died from infection caused by Gram negative pathogens and polymicrobial infections. Therefore, in complicated skin and soft tissue infections ...
Switching between tricyclic, SSRI and related antidepressants
... used at the right dose for an appropriate duration of time, or the presence of intolerable side effects. When switching between antidepressants there is the potential for interaction between the two agents and/or for the patient to experience drug discontinuation symptoms from withdrawal of the firs ...
... used at the right dose for an appropriate duration of time, or the presence of intolerable side effects. When switching between antidepressants there is the potential for interaction between the two agents and/or for the patient to experience drug discontinuation symptoms from withdrawal of the firs ...
The treatment challenges of restless legs syndrome
... RLS is well documented and the heritability is 54–83 per cent. Concordance among monozygotic twins is 50–80 per cent with variable symptom expression.10 Secondary RLS, however, is related to an underlying health condition and can be aggravated by certain medications. At least 20 medical conditions ...
... RLS is well documented and the heritability is 54–83 per cent. Concordance among monozygotic twins is 50–80 per cent with variable symptom expression.10 Secondary RLS, however, is related to an underlying health condition and can be aggravated by certain medications. At least 20 medical conditions ...
Neurotransmitters in alcoholism: A review of neurobiological and
... structures.[25] Glutamate mediated signal transmission is suppressed in the central nucleus of the amygdala following acute administration and it is an effect which is enhanced following chronic alcohol exposure.[26] The glutamate transmission is most likely affected due to alterations in the functi ...
... structures.[25] Glutamate mediated signal transmission is suppressed in the central nucleus of the amygdala following acute administration and it is an effect which is enhanced following chronic alcohol exposure.[26] The glutamate transmission is most likely affected due to alterations in the functi ...
Routine Use of Insulin Sensitizing Agents
... in animals. It is reassuring however, to note that no excess of teratogenic effects have been reported in human subjects. Side Effects Lactic acidosis with metformin is rare. The principle side effects to metformin are gastrointestinal, particularly abdominal cramping and diarrhea. These can be avoi ...
... in animals. It is reassuring however, to note that no excess of teratogenic effects have been reported in human subjects. Side Effects Lactic acidosis with metformin is rare. The principle side effects to metformin are gastrointestinal, particularly abdominal cramping and diarrhea. These can be avoi ...
Guidelines for choice of selective serotonin reuptake inhibitor in
... data were available. We compared each individual SSRI with the comparator SSRIs. Variance-weighted pooling of the relative effect size for each study showed no consistent differences in efficacy at endpoint in what were mostly short-term trials (typically of 6–8 weeks duration). However, the reducti ...
... data were available. We compared each individual SSRI with the comparator SSRIs. Variance-weighted pooling of the relative effect size for each study showed no consistent differences in efficacy at endpoint in what were mostly short-term trials (typically of 6–8 weeks duration). However, the reducti ...
nausea and vomiting - KSU Faculty Member websites
... are 2 to 3 times longer than that of ondansetron. These observations initially suggested that more frequent ondansetron administration would be required. However, it has now been shown that receptor blockade dose not correlate with elimination half-life and all 5HT3 antagonists can be effectively ad ...
... are 2 to 3 times longer than that of ondansetron. These observations initially suggested that more frequent ondansetron administration would be required. However, it has now been shown that receptor blockade dose not correlate with elimination half-life and all 5HT3 antagonists can be effectively ad ...
... extraction of the active irgredient from the formulation by addicts and recreational drug users destroys the controlled-release mechanism and results in a rapid surge of drug into the bloodstream. Serious side-effects and death have been reported from such misuse. In addition to the potential .for s ...
Elavil (amitriptyline)
... some antidepressants, particularly the SSRIs, to provide warnings in their package insert that the risk of suicide may be increased in depressed individuals (especially children) during the first several weeks after beginning an antidepressant. However, studies have found that when more people in a ...
... some antidepressants, particularly the SSRIs, to provide warnings in their package insert that the risk of suicide may be increased in depressed individuals (especially children) during the first several weeks after beginning an antidepressant. However, studies have found that when more people in a ...
Serotonin syndrome
Serotonin syndrome is a potential symptom of any number of life-threatening drug interactions which may follow therapeutic drug use, combination, overdose of particular drugs, or the recreational use of certain drugs. Serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonin on the CNS and/or peripheral nervous system. For this reason, some experts strongly prefer the terms serotonin toxicity or serotonin toxidrome which more accurately reflect that it is a form of poisoning. Other names include serotonin sickness, serotonin storm, serotonin poisoning, hyperserotonemia, or serotonergic syndrome.Excessive levels of serotonin produce a spectrum of specific symptoms including cognitive, autonomic, and somatic effects. Symptoms may range from barely perceptible to fatal. Numerous drugs and drug combinations have been reported to produce serotonin syndrome, though the exact mechanism is not well understood in many instances.Diagnosis includes observing symptoms and investigating patient history for causal factors (interacting drugs). The syndrome has a characteristic picture but can be mistaken for other illnesses in some people, particularly those with neuroleptic malignant syndrome. No laboratory tests can currently confirm the diagnosis. Hence it is diagnosed based on symptoms, disease course (that is, the progression of the disease) and the exclusion of other possible causes of the presenting symptoms.Treatment consists of discontinuing medications which may contribute and in moderate to severe cases administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation. The high-profile case of Libby Zion, who is generally accepted to have died from serotonin syndrome, resulted in changes to graduate medical education in New York State.