Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Neural engineering wikipedia , lookup
Synaptogenesis wikipedia , lookup
Neuroanatomy wikipedia , lookup
Development of the nervous system wikipedia , lookup
Channelrhodopsin wikipedia , lookup
Neuroregeneration wikipedia , lookup
Neuropsychopharmacology wikipedia , lookup
Diverse molecular families control the growth and guidance of developing axons. A. A large family of classical cadherins promote cell and axonal adhesion, primarily through homophilic interactions between cadherin molecules on adjacent neurons. Adhesive interactions are mediated through interactions of the extracellular EC1 domains. Cadherins transduce adhesive interactions though their cytoplasmic interactions with catenins, which link cadherins to the actin cytoskeleton. B. A diverse array of immunoglobulin superfamily proteins are expressed in the nervous system and mediate adhesive interactions. The three examples shown here, Source: NCAM, The L1, and TAG1, bind both homophilically heterophilically promote Growth and can Guidance of Axons, Principlesand of Neural Science, to Fifth Editon axon outgrowth and adhesion. These proteins contain both immunoglobulin domains (circles) and fibronectin type III domains (squares). Homophilic interactions typically involve amino terminal immunoglobulin Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available domains. Different Ig adhesion molecules interact with the cytoskeleton via diverse cytoplasmic mediators, only a few of which are shown here. at: http://mhmedical.com/ Accessed: May 12, 2017 C. Different Copyright ephrin proteins to Eph class tyrosine kinase receptors. Class A ephrins are linked to the surface membrane through a glycosyl © 2017bind McGraw-Hill Education. All rights reserved phosphatidylinositol tether, whereas class B ephrins are transmembrane proteins. Class A ephrins typically bind class A Eph kinases, and class B ephrins