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Unit 5 - Cell Growth and Division DNA, Mitosis, Meiosis, & Intro to genetics Term Nucleotides Definition A monomer that forms DNA and has a phosphate group, a sugar, and a nitrogen- containing base Double helix Model that compares the structure of a DNA molecule, in which two strands wind around one another, to that of a twisted ladder. Base pairing rule Replication DNA Polymerase Cell cycle Mitosis Rule that describes how nucleotides form bonds in DNA, Adenine (A) always bonds with thymine (T) and guanine (G) always bonds with cytosine (C) The process by which a strand of DNA and all of its genetic information are copied. Enzyme that makes bonds between nucleotides, forming an identical strand of DNA during replication It is a pattern of growth, DNA replication, and cell division that occurs in a eukaryotic cell The process by which a cell divides its nucleus and its contents Synthesis Cytokinesis Chromosome The process by which the cytoplasm of a cell divides Long, continuous thread of DNA that consists of numerous genes and regulatory information. Term Histone Definition Protein that organizes chromosomes and around which DNA wraps itself Chromatin Loose combination of DNA and proteins that is present during interphase of cell replication Chromatid one half of a duplicated chromosome Centromere Region of condensed chromosome that looks pinched: it is where spindle fibers attach during meiosis and mitosis Telomere Repeating nucleotide at the ends of DNA molecules that do not form genes. They help prevent the loss of genes Prophase First phase of mitosis when chromatin condenses, the nuclear envelope breaks down, the nucleolus disappears and the centrosomes and centrioles migrate to opposite sides of the cell Metaphase Second phase of mitosis when spindle fibers align the chromosomes along the cell equator (the middle of the cell) Anaphase Third phase of mitosis during which chromatids separate and are pulled to opposite sides of the cell (anaphase- apart) Telophase Last phase of mitosis when a complete set of identical chromosomes is positioned at each pole of the cell, the nuclear membranes start to form, the chromosomes begin to uncoil, and the spindle fiber Growth factors A broad group of proteins that stimulate cell division Term Apoptosis Definition Programmed cell death Cancer Common name for a class of diseases characterized by uncontrolled cell division Benign Having no dangerous effect on health, especially referring to an abnormal growth of cells that are not cancerous Malignant Cancerous tumor in which cells break away and spread to other parts of the body, causing harm to the organisms health Metastasize To spread by transferring a disease-causing agent from the site of the disease to other parts of the body carcinogen Substance that produces or promoted the development of cancer Asexual reproduction Process by which offspring are produced from a single parent; does not involve joining of gametes (ie: no sperm combining with egg) Binary fission Form of asexual reproduction in which a cell divides into two equal parts Budding a form of asexual reproduction in which a new individual develops from some generative anatomical point of the parent organism Fragmentation A form of asexual reproduction wherein a parent organism breaks into fragments, each capable of growing independently into a new organism Term Vegetative reproduction Definition Asexual reproduction in which a stem leaf or root will produce a new individual when detached from a parent plant Somatic cells Cell that makes up all of the body tissues and organs, except for gametes Gamete Sex cell; an egg or sperm cell Homologous chromosomes Chromosomes that have the same length, appearance, and copies of genes, although the alleles may differ Autosome Chromosome that contains genes for characteristics not directly related to the sex of the organism Sex chromosome Chromosome that directly controls the development of sexual characteristics Sexual reproduction Process by which two gametes fuse and produce offspring that are genetically a mixture of both parents Fusion of an egg and sperm cell Fertilization Diploid Cell that has two copies of each chromosome, one from an egg and one from a sperm (think diploid =double) Haploid Cell that has only one copy of each chromosome (Think haploid =half) Term Meiosis Sperm Definition Form of nuclear division that divides a diploid cell into haploid cells; important in forming gametes (egg and sperm) for sexual reproduction Process by which gametes are produced through the combination of meiosis and other maturational changes Male gamete Egg Female gamete Traits Characteristic that is inherited (or passed from parent to offspring) Genetics Study of heredity patterns and variation of organisms Purebred Type of organism that whose ancestors are genetically uniform Cross Mating of two organisms Law of segregation Mendel’s 1st law, stating that (1) organisms inherit two copies of genes, one from each parent, and (2) organisms donate only one copy of each gene in their gametes because the genes separate during gamete formation Gene Specific region of DNA that codes for a particular protein Gametogenesis Term Allele definition Any of the alternative forms of a gene that occurs at a specific place on a chromosome Homozygous Characteristic of having two of the same alleles at the same locus of sister chromatids Heterozygous Characteristic of having two different alleles that appear at the same locus of sister chromatids Genome All of an organisms genetic material Genotype Collection of all of an organisms genetic information that codes for traits Phenotype Collection of all of an organisms physical characteristics Dominant Allele that is expressed when two different alleles are present in an organisms genotype Recessive Allele that is not expressed unless two copies of it are present in an organisms genotype Punnett Square Model for predicting all possible genotypes resulting from a cross or mating Monohybrid cross Cross or mating, between organisms that involves only one pair of contrasting traits Term Testcross Dihybrid cross definition Cross between an organism with an unknown genotype and an organism with a recessive phenotype Cross, or mating between organisms involving two pairs of contrasting traits Law of independent assortment Mendel’s 2nd law, stating that the allele pairs separate from one another during gamete formation Probability Likelihood that a particular event will happen Crossing over Exchange of chromosome segments between homologous chromosomes during meiosis I Genetic linkage Tendency for genes located close together on the same chromosome to be inherited together