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Biology 358 – Neuroanatomy Final Exam Please print your name clearly on the back of every page of the exam, just in case the staple doesn’t hold. Please read the instructions preceding each section carefully. Note: Final exams are not returned! If you want to see your final exam you must stop into my office sometime while I am there during the first two weeks of next term. Exams may not be taken out of my office. All exams will be shredded on the first day of week 3 of spring term. Section 1: Pictures. Please note the following ground rules concerning this section of the exam—especially the last bulleted item! (100 points max) • The following pictures have their numbers—but the level of section is not indicated. • Some of the items requested may not be on any of the accompanying diagrams. • You may not need to utilize all of the diagrams. • 2 points will be awarded for each and every structure labeled properly on the following spinal cord and brain sections. • 2 points will be subtracted for any structure that is labeled on a section where that structure does not exist. 1. Circle all FON on any and all of the accompanying diagrams that are involved in the transmission of information dealing with conscious proprioception, 2point discrimination and fine touch from the upper appendage. Label this item on all diagrams with the number 1. 2. Label any and all examples of the large cell and small cell reticular formation nuclei. Label these structure on all diagrams with the numbers 2a (large cell reticular formation nucleus) and 2b (small cell reticular formation nucleus). 3. Circle any and all structures on the accompanying diagrams that serve as the primary reflex relay center for the visual system. Label this structure on all diagrams with the number 3. (2) 4. Circle the tract on any and all of the accompanying diagrams that are involved in the transmission of information dealing with pain, temperature, and less discriminative touch. Label this item on all diagrams with the number 4. 5. The fibers of this descending motor tract originate in the premotor cortex of the frontal lobe, the primary motor cortex of the frontal lobe and the somesthetic cortex of the parietal lobe and decussate within the medulla of the brain. Circle this tract on any and all of the accompanying diagrams and label this item on all diagrams with the number 5. 6. The fibers of this descending motor tract originate in the premotor cortex of the frontal lobe, the primary motor cortex of the frontal lobe and the somesthetic cortex of the parietal lobe and decussate at their level of exit from the spinal cord. Circle this tract on any and all of the accompanying diagrams and label this item on all diagrams with the number 6. 7. Circle all SON on any and all of the accompanying diagrams that are involved in the transmission of information dealing with conscious proprioception, 2point discrimination and fine touch from the lower appendage. Label this item on all diagrams with the number 7. 8. Label the internal capsule with the number 8 on any and all appropriate diagrams. 9. Label VA on any and all appropriate diagrams. Label this structure on all diagrams with the number 9. 10. Label AN on any and all appropriate diagrams. Label this structure on all diagrams with the number 10. 11. Label the globus pallidus with the number 11 on any and all appropriate diagrams. 12. Circle the structure on any and all of the accompanying diagrams that has connections with the contralateral cerebellum and receives information from the cerebral cortex, red nucleus and dorsal column nuclei. Label this item on all diagrams with the number 12. 13. Circle any and all structures on the accompanying diagrams that serve as the primary reflex center for the auditory system. Label this structure on all diagrams with the number 13. 14. Label the decussation of the cerebral peduncles that would be found on any and all diagrams with the number 14. 15. Label VPL on any and all appropriate diagrams with the number 15. (3) 16. Label VPM on any and all appropriate diagrams with the number 16. Section 2: _____ Objective questions about new material. Place the most correct letter in the space provided. 17. Which of the following blood vessels directly supplies the medial surface of the temporal lobe of the brain with blood? a. b. c. d. e. f. g. h. k. l. m. o. p. r. s. t. u. u. w. vertebral artery internal carotid artery basilar artery posterior inferior cerebellar artery anterior inferior cerebellar artery internal auditory artery pontine arteries superior cerebellar artery posterior cerebral artery temporal branches of the posterior cerebral artery calcarine and parieto-occipital branches of the posterior cerebral artery posterior choroidal arteries posterior communicating artery anterior communicating artery anterior choroidal artery middle cerebral artery anterior cerebral artery more than one of the above none of the above (4) _____ 18. Which of the following blood vessels directly supplies the corpus callosum of the brain with blood? a. vertebral artery b. internal carotid artery c. basilar artery d. posterior inferior cerebellar artery e. anterior inferior cerebellar artery f. internal auditory artery g. pontine arteries h. superior cerebellar artery k. posterior cerebral artery l. temporal branches of the posterior cerebral artery m. calcarine and parieto-occipital branches of the posterior cerebral artery o. posterior choroidal arteries p. posterior communicating artery r. anterior communicating artery s. anterior choroidal artery t. middle cerebral artery u. anterior cerebral artery u. more than one of the above w. none of the above _____ 19. Which of the following vessels has a direct communication with the internal carotid artery and has frontal, temporal and parietal branches? a. vertebral artery b. internal carotid artery c. basilar artery d. posterior inferior cerebellar artery e. anterior inferior cerebellar artery f. internal auditory artery g. pontine arteries h. superior cerebellar artery k. posterior cerebral artery l. temporal branches of the posterior cerebral artery m. calcarine and parieto-occipital branches of the posterior cerebral artery o. posterior choroidal arteries p. posterior communicating artery r. anterior communicating artery s. anterior choroidal artery t. middle cerebral artery u. anterior cerebral artery u. more than one of the above w. none of the above (5) _____ 20. Which of the following vessels directly supplies the choroid plexus in the 3rd ventricle and also directly supplies the limbic system with blood? a. vertebral artery b. internal carotid artery c. basilar artery d. posterior inferior cerebellar artery e. anterior inferior cerebellar artery f. internal auditory artery g. pontine arteries h. superior cerebellar artery k. posterior cerebral artery l. temporal branches of the posterior cerebral artery m. calcarine and parieto-occipital branches of the posterior cerebral artery o. posterior choroidal arteries p. posterior communicating artery r. anterior communicating artery s. anterior choroidal artery t. middle cerebral artery u. anterior cerebral artery u. more than one of the above w. none of the above _____ 21. Which of the following vessels directly supplies the cerebellar peduncles, cerebellar cortex, deep cerebellar nuclei and the corpora quadrigemina with blood? a. vertebral artery b. internal carotid artery c. basilar artery d. posterior inferior cerebellar artery e. anterior inferior cerebellar artery f. internal auditory artery g. pontine arteries h. superior cerebellar artery k. posterior cerebral artery l. temporal branches of the posterior cerebral artery m. calcarine and parieto-occipital branches of the posterior cerebral artery o. posterior choroidal arteries p. posterior communicating artery r. anterior communicating artery s. anterior choroidal artery t. middle cerebral artery u. anterior cerebral artery u. more than one of the above w. none of the above (6) _____ 22. Which of the following vessels directly supplies only the cerebellar cortex and deep cerebellar nuclei? a. vertebral artery b. internal carotid artery c. basilar artery d. posterior inferior cerebellar artery e. anterior inferior cerebellar artery f. internal auditory artery g. pontine arteries h. superior cerebellar artery k. posterior cerebral artery l. temporal branches of the posterior cerebral artery m. calcarine and parieto-occipital branches of the posterior cerebral artery o. posterior choroidal arteries p. posterior communicating artery r. anterior communicating artery s. anterior choroidal artery t. middle cerebral artery u. anterior cerebral artery u. more than one of the above w. none of the above If the following questions are true place a (+) in the space provided; if the statement is false place a (O) in the space provided. (2 points each) ____ 23. The optic disk is the point at which the bipolar cells exit the eye and enter the optic nerve. ____ 24. The inner plexiform layer of the retina contains the axons of bipolar cells, the dendrites of ganglion cells, and the processes of association cells. ____ 25. Axons of the third order neurons in the optic tract have their somas in the LGN and form the geniculocalcarine tract (also termed the optic radiation). ____ 26. A lesion in the left optic nerve rostral to the optic chiasma would result in complete blindness in the left eye. ____ 27. A lesion of the complete optic chiasma would result in bitemporal hemianopsia (blindness in the lateral portions of each visual field). ____ 28. The cell bodies of the bipolar primary (FON) neurons would be found within the cochlear ganglion (also termed the spiral ganglion). (7) ____ 29. The central processes of the bipolar neurons form the cochlear division of the vestibulocochlear nerve. ____ 30. The nerve fibers of the FON of the cochlear division of the vestibulocochlear nerve bifurcate and end in the dorsal and ventral cochlear nuclei. The dorsal cochlear nucleus receives fibers dealing with high frequency sound, while the ventral cochlear nucleus receives fibers dealing with low frequency sound. ____ 31. The vestibular nuclei receive input from cerebellum, spinal cord and vestibular cortex in addition to FON of the vestibular portion of the vestibulocochlear nerve. ____ 32. The olfactory pathway is a two neuron pathway. The FON is composed of the bipolar olfactory cells of the olfactory mucosa. These cells are believed to serve both as sensory receptors and FON cells. ____ 33. The olfactory tract divides into two olfactory striae. The lateral olfactory stria is closely related to the limbic system, and is believed to not play a role in the perception of smell. The medial olfactory stria projects to the primary olfactory cortex in the temporal lobe. ____ 34. The olfactory cortex is believed to project to the autonomic nervous system (via the hypothalamus) as well as to the limbic system. ____ 35. The limbic lobe is believed to be comprised of the cingulate gyrus, parahippocampal gyrus, uncus, subcallosal gyrus, and associated subcortical nuclei (amygdaloid nucleus hypothalamic and thalamic nuclei). ____ 36. The hippocampal formation is believed to have afferent connections from the olfactory association cortex, contralateral hippocampus, hypothalamus, thalamus, other widespread areas of the cerebral cortex, and the basal ganglia. ____ 37. The amygdala (amygdaloid nucleus) of the limbic system is believed to have afferent connections from the olfactory bulb and olfactory cortex, and efferent connections to the hypothalamus and habenula (nuclei of the diencephalon). ____ 38. Lesions in various regions of the amygdala may results in deficits ranging from decreased emotional tone, fear, hyperphagia and various pleasurable reactions. ____ 39. Unilateral lesions in the amygdala produces hypersexuality and perverted sexual behavior. This syndrome is termed Kluver-Bucy Syndrome. (8) Section 3: Essay questions. Answer the following questions on the blank pages provided at the end of this section. Be sure to be as all-inclusive in your answer as possible, thereby clearly demonstrating your understanding Each question is worth the number of points indicated. Should you need more paper feel free to come up and obtain some. 40. Draw a cross section of the spinal cord and discuss the anatomy of the spinal cord in cross section, including nuclear groups. You are not discuss the spinal tracts in this question. (10 points) 41. You are called to provide a neurological consultation to a General Practitioner in a local hospital. When you read the patient's chart you note that the attending General Practitioner has diagnosed the individual as having a lesion in the corpus callosum. In order to confirm or reject this diagnosis you walk into the examining room and give the patient a verbal command to pick up a pencil that is on the desk with his left hand. The patient is unable to do this, and therefore you know that the General Practitioner's diagnosis is correct. Explain how you were able to deduce this based upon this one fact. In addition, briefly (no more than 1-2 sentences) explain how you would determine that the damage was not in the auditory association cortex. (10 points) 42. A left-handed, 42-year old, male professional beer drinker awoke one morning, following a strenuous workout with his team, with generalized weakness in the upper and lower extremities of both sides and pronounced bilateral diminution of pain and temperature sensibility on both sides of the body below the neck. There were no apparent disturbances of position sense, vibratory sensibility, or tactile discrimination. Localize the problem anatomically and give a reason for your answer. (20 points) 43. Discuss the functional considerations of the cerebellum. (15 points)