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Transcript
Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle Pyruvate oxidation and the citric acid cycle take place in the mitochondrial matrix. Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle Pyruvate is oxidized to acetate, with the formation of NADH + H+ and the release of CO2. Acetate is activated by combination with coenzyme A, yielding acetyl CoA. Figure 7.8 Pyruvate Oxidation and the Citric Acid Cycle Malate is oxidized to oxaloacetate with the formation of NADH + H+. Oxaloacetate can now react with acetyl CoA to reenter the cycle. The two-carbon acetyl group and four-carbon oxaloacetate combine, forming six-carbon citrate. Citrate is rearranged to form its isomer, isocitrate. Fumarate and water react, forming malate. Succinate is oxidized to fumarate, with the formation of FADH2. Succinyl CoA releases coenzyme A, becoming succinate, the energy thus released converts GDP to GTP, which in turn converts ADP to ATP. Isocitrate is oxidized to -ketoglutarate, yielding NADH + H+ and CO2 -Ketoglutarate is oxidized to succinyl CoA with the formation of NADH + H+ and CO2; this step is almost identical to pyruvate oxidation.
