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1.2 Genes: Answers and Questions (Page 16) Chromosome – a thread-like structure made mostly of DNA, found in the nucleus of a cell DNA (deoxyribonucleic acid) – material found in the cell nucleus that contains genetic information Gene – a segment of DNA that controls protein production Genome Management Information System, Oak Ridge National Laboratory http://genomics.energy.gov Copyright © 2010 McGraw-Hill Ryerson Ltd. The DNA Code (Pages 17-18) In 1953 scientists James Watson and Francis Crick created this model of DNA (the twisted ladder design is sometimes called a “double helix”). Copyright © 2010 McGraw-Hill Ryerson Ltd. DNA Screening (Pages 19-20) A karyotype is a micrograph of the chromosomes in a person’s cells. Individual chromosomes from the karyotype can be mapped and then be examined for any irregularities. Karyotype http://www.genome.gov/Pages/Hyperion//DIR/VIP/Glossary/Illustration/k aryotype.shtml Common Genetic Disorders • Down Syndrome – caused by the presence of all or part of a 21st chromosome • Turner Syndrome – caused by one or many parts of the X chromosome remaining absent during cell formation. Specific only to females. • Cystic Fibrosis – Number one most common fatally genetic disease. Caused by a single gene failing to produce a protein involved in choride balance in the body. Leads to scarring of the pancreas which results in decreased enzyme production, which further leads to malnutrition. Lung function is also impaired. Issues Related to DNA Screening ( Pages 19-20 ) DNA testing can reveal genetic disorders (such as Down Syndrome, PKU, Huntington Disease) and can help determine how susceptible a person might be to ailments such as cancers and heart disease. The controversy related to genetic testing revolves around a variety of social issues. (family) - sensitive Genome Management Information System, Oak Ridge National Laboratory http://genomics.energy.gov Copyright © 2010 McGraw-Hill Ryerson Ltd. Altering Genes / Transgenic Organisms (Pages 22-23) Transgenic Organism – an organism whose genetic information has been altered with the insertion of genes from another species. These organisms are considered to be genetically modified organisms (GMOs). Possible Uses For GMOs • Production of non-allergenic human proteins • Development of pest resistant crops • Increased growth of crops and livestock Concerns • Spread of disease from GMOs • Negative effects on ecosystems • Allergic reactions from eating GMOs Copyright © 2010 McGraw-Hill Ryerson Ltd. Cloning (Pages 24-25) Cloning – the process of creating identical genetic copies of an organism Pros and Cons of Cloning • Pro: Copies are made of “superior” animals. (increased milk & meat production) • Con: Clones may be less disease resistant Copyright © 2010 McGraw-Hill Ryerson Ltd. Mutations ( Pages 26-27 ) Mutation – a change in the DNA of an organism Mutagen – a substance or factor that can cause a mutation in DNA. Examples: radiation (X-Rays, UV radiation), mercury, cigarette tar Copyright © 2010 McGraw-Hill Ryerson Ltd. Section 1.2 Review ( Page 28 ) Concepts to be reviewed: • genetic material in the nucleus: DNA, chromosomes, and genes • the structure of DNA • DNA screening and related issues • issues related to altering genes • transgenic organisms • cloning • mutations Copyright © 2010 McGraw-Hill Ryerson Ltd.